Leslie Benet, PhD

Phone: +1 415 476-3853
Fax: +1 415 476-8887
513 Parnassus Avenue, MSB, Rm 822B
UCSF Box 0912
San Francisco, CA 94117
United States


Departmental research area

My research expertise

pharmacokinetics, pharmacodynamics, pharmacogenomics, drug transporters, drug metabolism, drug-drug interactions, biopharmaceutics, drug delivery, enzymes and transporters, biopharmaceutics classification system (BCS), biopharmaceutics drug disposition classification system (BDDCS)

Professional background


Dr. Benet, Professor and former Chairman (1978-1998), Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, received his A.B. (English), B.S. (Pharmacy), M.S. from the University of Michigan and Ph.D. from the University of California. He has received nine honorary doctorates: Uppsala University, Sweden (Pharm.D., 1987), Leiden University, The Netherlands (Ph.D., 1995), University of Illinois at Chicago (D.Sc., 1997), Philadelphia College of Pharmacy and Science (D.Sc., 1997), Long Island University (D.Sc., 1999), University of Athens, Greece (Ph.D., 2005), Catholic University of Leuven, Belgium (Ph.D., 2010), University of Michigan (D.Sc., 2011) and Universidade de Lisboa, Lisbon, Portugal (Ph.D., 2016). His research interests, more than 620 publications, 7 books and 12 patents are in the areas of pharmacokinetics, biopharmaceutics, drug delivery and pharmacodynamics. Dr. Benet is listed by Thompson Reuters as one of the most highly cited pharmacologists worldwide, with his published peer-reviewed papers cited more than 32,000 times on Clarivate Analytics and more than 50,000 times on Google Scholar. His most recent work has addressed the interplay of metabolic enzymes and transport proteins as related to oral bioavailability and hepatic elimination, and the development of the Biopharmaceutics Drug Disposition Classification System (BDDCS). Dr. Benet was a Founder/Editor of the JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS (1973-98) and Associate Editor of PHARMACOLOGY AND THERAPEUTICS (1995-2000). He presently serves a member of the Editorial boards of PHARMACOLOGY, CHEMICAL AND PHARMACEUTICAL BULLETIN, AAPS JOURNAL and ARCHIVES OF DRUG INFORMATION. He is a Fellow of the Academy of Pharmaceutical Sciences and Research, the American Association of Pharmaceutical Scientists (AAPS), the American College of Clinical Pharmacology (ACCP), the Controlled Release Society (CRS) and the American Association for the Advancement of Science. In 1982, Dr. Benet received the American Pharmacists Association (APhA) Academy of Pharmaceutical Sciences (APS) Research Achievement Award in Pharmaceutics and the University of Michigan, College of Pharmacy, Distinguished Alumnus Award. In 1985, he served as President of APS. During 1986, Dr. Benet was a Founder and first President of the AAPS. In 1987, Dr. Benet was elected to membership in the Institute of Medicine (IOM) of the National Academy of Sciences. In 1988, he received the ACCP Distinguished Service Award and in 1989, the initial AAPS Distinguished Pharmaceutical Scientist Award. In 1990, he was the recipient of the Rho Chi Lecture Award, and the UCSF Long Teaching Award, while in 1991, he received the Volwiler Research Achievement Award of the American Association of Colleges of Pharmacy (AACP). In 1993-94, he served as AACP President. In 1995, he received the Rawls-Palmer Progress in Medicine Award of the American Society for Clinical Pharmacology and Therapeutics (ASCPT) and delivered the American College of Clinical Pharmacy “Therapeutic Frontiers Lecture”. In 1996, he received the AAPS Distinguished Service Award, and in 2000 the APhA Takeru Higuchi Research Prize and the AAPS Wurster Research Award in Pharmaceutics. In 2001 he was awarded the Høst-Madsen Medal of the International Pharmaceutical Federation (FIP) and the UCSF Outstanding Faculty Mentorship Award. In 2004, he was awarded the Pharmaceutical Sciences World Congress Research Achievement Award and the CRS Career Achievement in Oral Drug Delivery Award. In 2007 he was selected as the UCSF Distinguished Clinical Research Lecturer and is still the only non-MD so honored. In 2010, he received the ASCPT Hunter Memorial Award in Therapeutics and in 2011 the ACCP Distinguished Investigator award. In 2012, the September issue of PHARMACEUTICAL RESEARCH was dedicated in his honor under the title “50 Years of Scientific Excellence and Still Going Strong” and he was made an honorary member of FIP. In March 2013, he was awarded the APhA Ebert Prize and the September issue of JOURNAL OF PHARMACEUTICAL SCIENCES was dedicated in his honor. Dr. Benet formerly served as Chair of the Pharmacology Study Section and the Pharmacological Sciences Review Committee for the NIH, the FDA CBER Peer Review Committee, the FDA Expert Panel on Individual Bioequivalence, the Board of Pharmaceutical Sciences of the FIP, the Organizing Committee for the FIP Millennial World Congress of Pharmaceutical Sciences, the Congressionally mandated IOM/National Research Council (NRC) Committee on Accelerating the Research, Development and Acquisition of Medical Countermeasures Against Biological Warfare Agents and as a member of the FDA Generic Drugs Advisory Committee, the FDA Science Board and the NRC Biodefense Standing Committee. From 2007-2012 he served as Chair of the FIP Foundation for Education and Research. He presently serves on the Boards of Directors of the American Foundation for Pharmaceutical Education, Impax Laboratories, and Medicines360, of which the latter, he chairs. SEPTEMBER 2013

Research keywords

  • Hepatocytes
  • Cytochrome P-450 CYP3A
  • Cyclosporine
  • biopharmaceutics
  • Nitroglycerin
  • Intestinal Absorption
  • Cytochrome P-450 Enzyme System
  • Metabolic Clearance Rate
  • pharmacokinetics
  • Microsomes, Liver
  • Therapeutic Equivalency
  • drug interactions
  • liver
  • Biological Models
  • Pharmaceutical Preparations