Publications: Winter 2015

Pharmaceutical Chemistry faculty members have published the following manuscripts since January 2015

• An improved single-chain Fab platform for efficient display and recombinant expression⁷.
  Koerber JT, Hornsby MJ, Wells JA.
  J Mol Biol. 2015 Jan 30;427(2):576-86.

• Small molecules enhance CRISPR genome editing in pluripotent stem cells⁸.
  Yu C, Liu Y, Ma T, Liu K, Xu S, Zhang Y, Liu H, La Russa M, Xie M, Ding S, Qi LS.
  Cell Stem Cell. 2015 Feb 5;16(2):142-7.

• Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism⁹.
  Torres IO, Kuchenbecker KM, Nnadi CI, Fletterick RJ, Kelly MJ, Fujimori DG.
  Nat Commun. 2015 Feb 17;6:6204.

• A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity¹⁰. Cerchiari AE, Garbe JC, Jee NY, Todhunter ME, Broaders KE, Peehl DM, Desai TA, LaBarge MA, Thomson M, Gartner ZJ.
  Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2287-92.

• The Membrane- and Soluble-Protein Helix-Helix Interactome: Similar Geometry via Different Interactions¹¹.
  Zhang SQ, Kulp DW, Schramm CA, Mravic M, Samish I, DeGrado WF.
  Structure. 2015 Mar 3;23(3):527-41.

• Homer3 regulates the establishment of neutrophil polarity¹².
  Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD.
  Mol Biol Cell. 2015 Mar 4. pii: mbc.E14-07-1197.

• Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia¹³.
  Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R¹, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Mark Ansel K, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M.
  Cancer Cell¹⁴. 2015 Mar 9;27(3):409-25.

• Erratum: Covalent docking of large libraries for the discovery of chemical probes¹⁵.
  London N, Miller RM, Krishnan S, Uchida K, Irwin JJ, Eidam O, Gibold L, Cimermančič P, Bonnet R, Shoichet BK, Taunton J.
  Nat Chem Biol. 2015 Mar;11(3):235