Publications: Spring 2015

Department of Pharmaceutical Chemistry faculty members have published the following manuscripts since March 2015.

• Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas’ disease.
  Neitz RJ, Bryant C, Chen S, Gut J, Hugo Caselli E, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR.
  Bioorg Med Chem Lett. 2015 Jun 23. pii: S0960-894X(15)00659-9.

• Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome.
  O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ.
  Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7478-83.

• Signal transduction in histidine kinases: insights from new structures.
  Bhate MP, Molnar KS, Goulian M, DeGrado WF.
  Structure. 2015 Jun 2;23(6):981-94.

• Biophysical methods for identifying fragment-based inhibitors of protein-protein interactions.
  Pfaff SJ, Chimenti MS, Kelly MJ, Arkin MR.
  Methods Mol Biol. 2015;1278:587-613.

• Radical SAM-Mediated Methylation of Ribosomal RNA.
  Stojković V, Fujimori DG.
  Methods Enzymol. 2015;560:355-76.

• Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity.
  Kane JR, Stanley DJ, Hultquist JF, Johnson JR, Mietrach N, Binning JM, Jónsson SR, Barelier S, Newton BW, Johnson TL, Franks-Skiba KE, Li M, Brown WL, Gunnarsson HI, Adalbjornsdóttir A, Fraser JS, Harris RS, Andrésdóttir V, Gross JD, Krogan NJ.
  Cell Rep. 2015 May 26;11(8):1236-50.

• Isoform Selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.
  Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM Jr, Zuiderweg ER, Gestwicki JE, Dickey CA.
  J Biol CJ Biol Chem. 2015 May 22;290(21):13115-27.

• The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
  Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D.
  Sci Transl Med. 2015 May 20;7(288):288ra79.

• Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus.
  Chow JY, Tian BX, Ramamoorthy G, Hillerich BS, Seidel RD, Almo SC, Jacobson MP, Poulter CD.
  Proc Natl Acad Sci U S A. 2015 May 5;112(18):5661-6.

• Multidomain Assembler (MDA) Generates Models of Large Multidomain Proteins.
  Hertig S, Goddard TD, Johnson GT, Ferrin TE.
  Biophys J. 2015 May 5;108(9):2097-102.

• RRDistMaps: a UCSF Chimera tool for viewing and comparing protein distance maps.
  Chen JE, Huang CC, Ferrin TE.
  Bioinformatics. 2015 May 1;31(9):1484-6.

• Conversion of non-adipogenic fibroblasts into adipocytes by a defined hormone mixture.
  Nie T, Hui X, Gao X, Nie B, Mao L, Tang X, Yuan R, Li K, Li P, Xu A, Liu P, Ding S, Han W, Cooper GJ, Wu D.
  Biochem J. 2015 May 1;467(3):487-94.

• Homer3 regulates the establishment of neutrophil polarity.
  Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD.
  Mol Biol Cell. 2015 May 1;26(9):1629-39.

• NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling.
  Bradshaw RA, Pundavela J, Biarc J, Chalkley RJ, Burlingame AL, Hondermarck H.
  Adv Biol Regul. 2015 May;58:16-27.

• Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance.
  Martin MD, Calcul L, Smith C, Jinwal UK, Fontaine SN, Darling A, Seeley K, Wojtas L, Narayan M, Gestwicki JE, Smith GR, Reitz AB, Baker BJ, Dickey CA.
  ACS Chem Biol. 2015 Apr 17;10(4):1099-109.

• Ecotin: Exploring a feasible antithrombotic profile.
  Wermelinger LS, Frattani FS, Carneiro-Lobo TC, Craik CS, Castro HC, Zingali RB.
  Int J Biol Macromol. 2015 Apr 13. pii: S0141-8130(15)00244-5.

• Altered cofactor regulation with disease-associated p97/VCP mutations.
  Zhang X, Gui L, Zhang X, Bulfer SL, Sanghez V, Wong DE, Lee Y, Lehmann L, Lee JS, Shih PY, Lin HJ, Iacovino M, Weihl CC, Arkin MR, Wang Y, Chou TF.
  Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1705-14.

• Imaging active urokinase plasminogen activator in prostate cancer.
  LeBeau AM, Sevillano N, Markham K, Winter MB, Murphy ST, Hostetter DR, West J, Lowman H, Craik CS, VanBrocklin HF.
  Cancer Res. 2015 Apr 1;75(7):1225-35.