Publications: fall 2015

Pharmaceutical Chemistry faculty members have published the following manuscripts between October and December 2015.

• Improved Peak Detection and Deconvolution of Native Electrospray Mass Spectra from Large Protein Complexes.⁷
  Lu J, Trnka MJ, Roh SH, Robinson PJ, Shiau C, Fujimori DG, Chiu W, Burlingame AL, Guan S.
  J Am Soc Mass Spectrom. 2015 Dec;26(12):2141-51.

• Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.⁸
  Roh SH, Kasembeli M, Galaz-Montoya JG, Trnka M, Lau WC, Burlingame A, Chiu W, Tweardy DJ.
  J Biol Chem. 2015 Dec 24.

• Functional coupling between writers, erasers and readers of histone and DNA methylation.⁹
  Torres IO, Fujimori DG.
  Curr Opin Struct Biol. 2015 Dec;35:68-75.

• Covalent targeting of acquired cysteines in cancer.¹⁰
  Visscher M, Arkin MR, Dansen TB.
  Curr Opin Chem Biol. 2015 Nov 26;30:61-67.

• Allosteric N-WASP activation by an inter-SH3 domain linker in Nck.¹¹
  Okrut J, Prakash S, Wu Q, Kelly MJ, Taunton J.
  Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6436-45.

• High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction.¹²
  Thomaston JL, Alfonso-Prieto M, Woldeyes RA, Fraser JS, Klein ML, Fiorin G, DeGrado WF.
  Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14260-5.

• Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease.¹³
  Neitz RJ, Bryant C, Chen S, Gut J, Caselli EH, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR.
  Bioorg Med Chem Lett. 2015 Nov 1;25(21):4834-7.

• Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin.¹⁴
  Pan S, Sommese RF, Sallam KI, Nag S, Sutton S, Miller SM, Spudich JA, Ruppel KM, Ashley EA.
  BMC Med Genet. 2015 Oct 26;16:97.

• Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies.¹⁵
  Pollock NI, Wang L, Wallweber G, Gooding WE, Huang W, Chenna A, Winslow J, Sen M, DeGrave KA, Li H, Zeng Y, Grandis JR.Clin Cancer Res. 2015 Oct 15;21(20):4597-606.

• A High Through-put Platform for Recombinant Antibodies to Folded Proteins.¹⁶
  Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, Hoey RJ, Lai D, Griffin C, Li Z, Vizeacoumar FJ, Dong D, Campbell E, Anderson S, Zhong N, Gräslund S, Koide S, Moffat J, Sidhu S, Kossiakoff A, Wells J.
  Mol Cell Proteomics. 2015 Oct;14(10):2833-47.

• Prediction and validation of enzyme and transporter off-targets for metformin.¹⁷
  Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM.
  J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):463-75.