Publications: Winter 2016

Pharmaceutical Chemistry faculty members have published the following manuscripts between January and March 2016:

• saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.
  Portnoy V, Lin SH, Li KH, Burlingame A, Hu ZH, Li H, Li LC. Cell Res. 2016 Mar;26(3):320-35.

• Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.
  Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. Proc Natl Acad Sci U S A. 2016 Mar 22.

• Perceived Impact of a Land and Property Rights Program on Violence Against Women in Rural Kenya: A Qualitative Investigation.
  Hilliard S, Bukusi E, Grabe S, Lu T, Hatcher AM, Kwena Z, Mwaura-Muiru E, Dworkin SL. Violence Against Women. 2016 Mar 6.

• Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.
  Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S. Cell Stem Cell. 2016 Mar 3;18(3):368-81.

• Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly.
  Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki JE, French SW. Int J Antimicrob Agents. 2016 Mar 2.

• In Vitro and In Vivo Characterization of the Alkaloid Nuciferine.
  Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein A, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL. PLoS One. 2016 Mar 10;11(3):e0150602.

• Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Towards Endogenous Substrates.
  Zhao Y, Wan D, Yang J, Hammock BD, Ortiz De Montellano PR. Drug Metab Dispos. 2016 Mar 2.

• CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.
  Cimermancic P, Weinkam P, Rettenmaier TJ, Bichmann L, Keedy DA, Woldeyes RA, Schneidman-Duhovny D, Demerdash ON, Mitchell JC, Wells JA, Fraser JS, Sali A. J Mol Biol. 2016 Feb 22;428(4):709-19.

• Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells.
  Ramirez M, Rajaram S, Steininger RJ, Osipchuk D, Roth MA, Morinishi LS, Evans L, Ji W, Hsu CH, Thurley K, Wei S, Zhou A, Koduru PR, Posner BA, Wu LF, Altschuler SJ. Nat Commun. 2016 Feb 19;7:10690.

• Structure- and function-based design of Plasmodium-selective proteasome inhibitors.
  Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M. Nature. 2016 Feb 11;530(7589):233-6.

• 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.
  Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, Subramaniam S. Science. 2016 Feb 19;351(6275):871-5.

• Continuum descriptions of membranes and their interaction with proteins: Towards chemically accurate models.
  Argudo D, Bethel NP, Marcoline FV, Grabe M. Biochim Biophys Acta. 2016 Feb 4.

• Covalent targeting of acquired cysteines in cancer.
  Visscher M, Arkin MR, Dansen TB. Curr Opin Chem Biol. 2016 Feb;30:61-7.

• Impact of very low physical activity, BMI, and comorbidities on mortality among breast cancer survivors.
  Nelson SH, Marinac CR, Patterson RE, Nechuta SJ, Flatt SW, Caan BJ, Kwan ML, Poole EM, Chen WY, Shu XO, Pierce JP. Breast Cancer Res Treat. 2016 Feb;155(3):551-7. doi: 10.1007/s10549-016-3694-2. Epub 2016 Feb 10.

• Translation from the 5' untranslated region shapes the integrated stress response.
  Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P. Science. 2016 Jan 29;351(6272).

• Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease.
  Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS. ChemMedChem. 2016 Jan 28.

• Guidelines and parameters: percutaneous sclerotherapy for the treatment of head and neck venous and lymphatic malformations.
  Heit JJ, Do HM, Prestigiacomo CJ, Delgado-Almandoz JA, English J, Gandhi CD, Albequerque FC, Narayanan S, Blackham KA, Abruzzo T, Albani B, Fraser JF, Heck DV, Hussain MS, Lee SK, Ansari SA, Hetts SW, Bulsara KR, Kelly M, Arthur AS, Patsalides A, Pride GL, Powers CJ, Alexander MJ, Meyers PM, Jayaraman MV; SNIS Standards and Guidelines committee. J Neurointerv Surg. 2016 Jan 22.

• Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks.
  Bieling P, Li TD, Weichsel J, McGorty R, Jreij P, Huang B, Fletcher DA, Mullins RD. Cell. 2016 Jan 14;164(1-2):115-27.

• Low-energy Shock Wave Therapy Ameliorates Erectile Dysfunction in a Pelvic Neurovascular Injuries Rat Model.
  Li H, Matheu MP, Sun F, Wang L, Sanford MT, Ning H, Banie L, Lee YC, Xin Z, Guo Y, Lin G, Lue TF. J Sex Med. 2016 Jan;13(1):22-32.

• Opposing Chromatin Signals Direct and Regulate the Demethylase Activity of KDM4C.
  Pack LR, Yamamoto KR, Fujimori DG. J Biol Chem. 2016 Jan 8.

• Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities.
  Chen S, Bremer AW, Scheideler OJ, Na YS, Todhunter ME, Hsiao S, Bomdica PR, Maharbiz MM, Gartner ZJ, Schaffer DV. Nat Commun. 2016 Jan 12;7:10309.

• Human pancreatic beta-like cells converted from fibroblasts.
  Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S. Nat Commun. 2016 Jan 6;7:1008

• Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci.
  Chen B, Hu J, Almeida R, Liu H, Balakrishnan S, Covill-Cooke C, Lim WA, Huang B. Nucleic Acids Res. 2016 Jan 5.

• Guidelines and parameters: percutaneous sclerotherapy for the treatment of head and neck venous and lymphatic malformations.
  Heit JJ, Do HM, Prestigiacomo CJ, Delgado-Almandoz JA, English J, Gandhi CD, Albequerque FC, Narayanan S, Blackham KA, Abruzzo T, Albani B, Fraser JF, Heck DV, Hussain MS, Lee SK, Ansari SA, Hetts SW, Bulsara KR, Kelly M, Arthur AS, Patsalides A, Pride GL, Powers CJ, Alexander MJ, Meyers PM, Jayaraman MV; SNIS Standards and Guidelines committee. J Neurointerv Surg. 2016 Jan 22.

• Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni.
  Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR. PLoS Negl Trop Dis. 2016 Jan 11;10(1):e0004356.

• TGF-β Signaling in Stem Cell Regulation.
  Li W, Wei W, Ding S. Methods Mol Biol. 2016;1344:137-45.