structural biology

A genetic shortcut to help visualize proteins at work

Fri Dec 11, 2020

Jamming the gears of a deadly virus

Fri Nov 13, 2020

NIH

A 3D printed model of a SARS-CoV-2 viral particle (blue) dotted with the spike protein (red) that enables the virus to infect human cells. The spike protein is the target of research efforts to prevent and treat COVID-19.

Team efforts at the School and beyond produce two potential treatments for COVID-19.

Overcoming disease with moving pictures and molecular building blocks

Mon Apr 13, 2020

Elisabeth Fall

Jaime Fraser, PhD

Jaime Fraser delivered the 2020 Byers Award Lecture in Basic Science

VR drug discovery makes precision therapy a reality

Wed Oct 16, 2019

Beth Apsel Winger, MD, PhD (left), and Matthew Jacobson, PhD (right) explore a cancer-causing mutation in a protein in virtual reality, using UCSF ChimeraX.

ChimeraX, virtual reality software developed at the UCSF Resource for Biocomputing, Visualization and Informatics, is now the tool of choice for computational structural biologists in the School of Pharmacy. The Jacobson Lab recently used ChimeraX to find a promising new cure for a drug-resistant...

Sali elected to National Academy of Sciences

Wed May 2, 2018

Andrej Sali, PhD

Andrej Sali, PhD, has been elected as a member of the 2018 class of the National Academy of Sciences (NAS).

Aashish Manglik, MD, PhD

Tue Sep 5, 2017

Associate Professor

I am a physician-scientist interested in understanding how the human body senses and responds to external stimuli. My research focuses on the largest group of drug targets in the human body, the G protein coupled receptors. We aim to understand the most basic principles of these receptors in order...

John Gross, PhD

Wed Mar 13, 2013

Professor

I am interested in protein structure and dynamics related to gene expression. We study changes in protein structure that occur on time scales ranging from millions of years to a millionth of a second, with a focus on basic questions of how viruses cross-species and give rise to modern pandemics...

Reflection: 30 years of top NIH funding for UCSF School of Pharmacy

Wed Dec 22, 2010

Kathy Giacomini, PhD (center), co-chair of the Department of Bioengineering and Therapeutic Sciences, discusses research results in the lab with postdocs Sook Wah Yee (left), and Amber Dahlin (right).

Table of contents

Introduction
Budget significance
Reasons for past success
A decade of funding for bioinformatics
New drug discovery directions attract support

Topics and Expertise: structural biology