UCSF

John Gross, PhD

Gross
Phone: +1 415 502-1897
Fax: +1 415 502-8298
600 16th St, Rm S512E
UCSF Box 2280
San Francisco, CA 94158
United States

What I do

I am interested in protein structure and dynamics related to gene expression. We study changes in protein structure that occur on time scales ranging from millions of years to a millionth of a second, with a focus on basic questions of how viruses cross-species and give rise to modern pandemics or how enzyme function is fine-tuned by cellular cues. Research in this area guides development of therapeutics for infectious disease and cancer.

Departmental research area

My research expertise

NMR spectroscopy, structural biology, enzymology

Degrees

PhD, Physical Chemistry, Massachusetts Institute of Technology (MIT), 1998
BS, Chemistry, Sewanee: The University of the South, 1992

Biography

We investigate molecular machines that coordinate gene expression or antiviral immunity. Research areas include : i- RNA decay enzymes that act in mRNA quality control and gene regulatory pathways, and ii- nucleic acid based immune systems that protect animals from viruses and neutralization of these systems by viral accessory proteins. We use tools from molecular biophysics to understand the structure and regulatory conformational dynamics in these systems with the ultimate goal of defining molecular mechanisms and avenues for structure based drug design.