John Gross, PhD

What I do

We seek to understand how viruses shut down the immune system and to discover small molecules that interfere with this process.

Departmental research area

My research expertise

enzymes, control of RNA, protein turnover in normal and virally infected cells, NMR spectroscopy, X-ray scattering, crystallography quantitative biochemical methods


PhD, Physical Chemistry, Massachusetts Institute of Technology (MIT), 1998
BS, Chemistry, Sewanee: The University of the South, 1992


We investigate molecular machines that coordinate gene expression or antiviral immunity. Research areas include : i- RNA decay enzymes that act in mRNA quality control and gene regulatory pathways, and ii- nucleic acid based immune systems that protect animals from viruses and neutralization of these systems by viral accessory proteins. We use tools from molecular biophysics to understand the structure and regulatory conformational dynamics in these systems with the ultimate goal of defining molecular mechanisms and avenues for structure based drug design.