UCSF

Aashish Manglik, MD, PhD

Manglik
Phone: +1 415 502-3744

UCSF centers, institutes, and research programs

What I do

I am a physician-scientist interested in understanding how the human body senses and responds to external stimuli. My research focuses on the largest group of drug targets in the human body, the G protein coupled receptors. We aim to understand the most basic principles of these receptors in order to develop new medications that are both more effective and have decreased side effects.

My research expertise

G-protein-coupled receptors (GPCRs), structural biology, signaling, protein dynamics

Degrees

MD, Medicine, Stanford University School of Medicine, 2016
PhD, Biophysics, Stanford University, 2014
BA, Chemistry and Biology, Washington University, 2008

Biography

Our laboratory seeks to understand how cells sense and respond to their external environment. In this endeavor, we study the numerous proteins that lie at the cellular surface that enable individual cells to decipher the enormous number of stimuli that coordinate normal physiology. To gain a fundamental understanding of such transmembrane signaling processes, we use a diverse array of techniques spanning biochemical and biophysical interrogation to protein engineering. Our ultimate goal is to use these insights to discover new approaches to precisely control cellular signaling.

Research keywords

  • G protein-coupled receptor
  • GPCR
  • opioid receptors
  • signaling
  • structural biology
  • protein biophysic
  • Receptors, G-Protein-Coupled
  • Hepcidins
  • beta-Arrestins
  • Receptors, Adrenergic, beta-2
  • Antibodies, Neutralizing
  • Cation Transport Proteins
  • Single-Domain Antibodies
  • Drug Repositioning
  • Receptors, Opioid, mu
  • Receptors, Opioid, delta
  • Hedgehog Proteins
  • Smoothened Receptor
  • Cryoelectron Microscopy
  • Sterols
  • Spike Glycoprotein, Coronavirus