Shuvo Roy, PhD

Professor
Department of Bioengineering and Therapeutic Sciences
Shuvo Roy headshot
[email protected]
Phone: +1 415 514-9666
Fax: +1 415 514-9656
1700 4th Street, Rm 203A
UCSF Box 2520
San Francisco, CA 94158
United States

Links

Roy Lab UCSF Profiles

Affiliations

Education programs

UCSF - UC Berkeley Joint Graduate Group in Bioengineering
Pharmaceutical Sciences and Pharmacogenomics Graduate Program (PSPG)
Director, UC Berkeley - UCSF Master of Translational Medicine (MTM) Program

UCSF centers, institutes, and research programs

Quantitative Biosciences Institute (QBI)
Codirector, Biomedical Micro/Nanotechnology Core Facility
Codirector, The Kidney Project
Principal Investigator, UCSF-Stanford Pediatric Device Consortium

What I do

I am a bioengineer working on medical device development to address clinical needs by leveraging my background in MEMS (microelectromechanical systems) along with advances in biomaterials, electronics, and nanotechnology to advance health world-wide.

Departmental research area

therapeutic bioengineering

My research expertise

medical devices, artificial organs, renal replacement, wireless sensors, biomedical electronics, m-Health, microfabrication, bioMEMS technology, MEMS technology

Professional background

Degrees

PhD, Electrical Engineering and Applied Physics, Case Western Reserve University, 2001
MS, Electrical Engineering and Applied Physics, Case Western Reserve University, 1995
BS, Physics, Mathematics, and Computer Science, Mount Union College, Alliance, Ohio, 1992

Biography

Shuvo Roy, PhD, is a translational bioengineer focusing on the development of medical devices to address unmet clinical needs through strong collaboration and a multidisciplinary approach.

Dr. Roy is a professor at the University of California, San Francisco in the Department of Bioengineering and Therapeutic Sciences (BTS), a joint department of the UCSF Schools of Pharmacy and Medicine, and is a faculty affiliate of the California Institute for Quantitative Biosciences (QB3). He is the director of the Biodesign Laboratory located on the Mission Bay campus. In addition, he serves as the Technical Director of The Kidney Project and is a founding member of the UCSF Pediatric Device Consortium. Dr. Roy is the Faculty Director of the joint UCSF-UC Berkeley Master of Translational Medicine (MTM) program. He has developed and currently teaches a course focused on medical device development and commercialization issues. He is the author of more than 100 publications and co-author of five book chapters, and holds multiple patents for device developments.

Before joining UCSF in 2008, Dr. Roy co-directed the BioMEMS Laboratory in the Department of Biomedical Engineering at Cleveland Clinic in Cleveland, Ohio, focusing on clinical applications of MEMS. In 1992 he earned a BS degree, magna cum laude, for triple majors in physics, mathematics, and computer science, from Mount Union College in Alliance, Ohio. In 1995, he earned an MS in electrical engineering and applied physics and, in 2001, he earned a PhD in electrical engineering and computer science, both from Case Western Reserve University in Cleveland, Ohio.

He is the recipient of a Top 40 under 40 award by Crain’s Cleveland Business in 1999 and the Clinical Translation Award at the 2nd Annual BioMEMS and Biomedical Nanotechnology World 2001 meeting. In 2003, Dr. Roy was selected as a recipient of the TR100, which features the world’s 100 Top Young Innovators as selected by Technology Review, the Massachusetts Institute of Technology’s Magazine of Innovation. In 2004, he was presented with a NASA Group Achievement Award for his work on harsh environment MEMS. In 2005, Dr. Roy was named as a Who’s Who in Biotechnology by Crain’s Cleveland Business. In 2005 and 2007, he was recognized as a Cleveland Clinic Innovator. In 2009, he was nominated for the Biotechnology Industry Organization's Biotech Humanitarian Award, which is given in recognition of an individual who has used biotechnology to unlock its potential to improve the earth. In 2012, he was presented the Rising Star Award by BayBio Pantheon, and in that same year, he received the Innovation Pathway 2.0 Award from the Food and Drug Administration (FDA). More recently, he was recognized as a Fellow by the American Institute of Medical and Biological Engineering (AIMBE). He is the recipient of the KidneyX Redesign Dialysis Phase 1 Prize, KidneyX Redesign Dialysis Phase 2 Prize, the KidneyX Artificial Kidney Phase 1 Prize, and most recently, the KidneyX Artificial Kidney Phase 2 Prize.

Research keywords

  • Renal Replacement
  • Sensors
  • Microelectromechanical Systems
  • Microtextured Substrates
  • Tissue Engineering
  • BioMEMS
  • Artificial Organs
  • therapeutics
  • Biocompatibility
  • nanotechnology
  • bioengineering
  • medical devices
  • artificial kidney
  • Transducers
  • Islets of Langerhans
  • Hemofiltration
  • Equipment and Supplies
  • Prostheses and Implants
  • Bioartificial Organs
  • silicon
  • Artificial Membranes
  • Electric Power Supplies
  • Kidneys, Artificial
  • Pancreas, Artificial
  • Dimethylpolysiloxanes
  • Extracorporeal Membrane Oxygenation
  • Nanopores
  • Oxygenators, Membrane
  • Renal Replacement Therapy
1. Update from the Dean: Putting plans in action
2. The Kidney Project proves its bioreactor can keep kidney cells alive for at least one week
3. Scaling up the bioartificial kidney at UCSF
4. Using the bioartificial kidney to free patients from dialysis
5. Update from the Dean: Ongoing excellence and new frontiers
6. Roy receives U.S. Presidential Volunteer Service Award
7. Update from the Dean: Passing the torch
8. Update from the Dean: A fond farewell
9. The Kidney Project successfully tests a prototype bioartificial kidney
10. Update from the Dean: Community during challenging times
11. Bioartificial kidney aims to mimic natural kidney function with $1 million grant from the John and Marcia Goldman Foundation
12. Update from the Dean: Back to school
13. The Kidney Project wins KidneyX Award to enable simpler, safer at-home dialysis
14. Update from the Dean: We are rising to the challenges presented by COVID-19
15. UCSF features expertise in kidney care and work on artificial kidney
16. Update from the Dean – November 2019
17. Implantable bioartificial kidney achieves preclinical milestone
18. School of Pharmacy leads in LivingGreen certifications
19. Update from the Dean – May 2019
20. The Kidney Project earns KidneyX award to make home dialysis better for patients
21. Kortemme and Desai honored at annual meeting of the American Institute for Medical and Biological Engineering
22. Update from the Dean – November 2018
23. The Kidney Project and the bioartificial pancreas: When inspiration strikes twice
24. UCSF School of Pharmacy leads in NIH funding for 38th year
25. Update from the Dean – March 2018
26. Wearable device monitors heart failure
27. Wired magazine visits The Kidney Project
28. NIH training grant supports device innovation at UCSF
29. Team member Sally Brown
30. UCSF School of Pharmacy leads in NIH funding for 36th year in a row
31. Update from the Dean - Fall/Winter 2015
32. Major funding for The Kidney Project from NIBIB Quantum Program
33. Roy receives JDRF funding to develop implants to treat type 1 diabetes
34. Update from the Dean - Fall/Winter 2014
35. UCSF team wins $2.7 million for innovative project to reduce premature births
36. Update from the Dean - Fall 2013
37. Feature articles shine spotlight on Kidney Project
38. Kidney Project receives two major gifts, increased Hind professorship endowment
39. Update from the Dean - Fall 2012
40. Roy inducted, honored as Rising Star by BayBio
41. Artificial kidney project receives $3 million from Goldman Foundation, NIH
42. Master of Translational Medicine program gets final UC approval
43. Home monitoring of heart failure via web-enabled bathroom scales wins award funding
44. Remembering Harry W. Hind - pharmacist, inventor, leader, benefactor
45. Artificial kidney project led by Roy cited at White House panel
46. Update from the Dean - Fall/Winter 2012
47. Consortium inventing medical devices for children gets new funding
48. In-flight programming features bioartificial kidney
49. Roy presents new research on artificial kidney membranes
50. Bioartificial kidney addition wins LEGO robot design awards
51. Update from the Dean - Fall/Winter 2011
52. Reflection: 30 years of top NIH funding for UCSF School of Pharmacy
53. SmartPlanet video features The Kidney Project
54. Roy shares promise of bioartificial kidney
55. Animation shows bioartificial kidney in action
56. Roy unveils model of bioartificial kidney
57. Update from the Dean - Fall/Winter 2010
58. Symposium on the future of therapeutics inaugurates new UCSF department
59. Update from the Dean - Spring/Summer 2009
60. Update from the Dean - Fall/Winter 2009
1. Medal of Excellence - Breakthrough Innovations, American Association of Kidney Patients, 2022
2. Presidential Volunteer Service Award - Gold Medal, U.S. Presidential Volunteer Service awards - nomination by American Association of Kidney Patients, 2022
3. Commendation for Exceptional Volunteerism and University Service, Organized, Rapid, Intelligent Fabrication (ORIF) Team for UCSF's COVD-19 Pandemic Response, 2021
4. KidneyX Artificial Kidney Phase 1, Winner, US Dept. of Health and Human Services & American Society of Nephrology, 2021
5. KidneyX Redesign Dialysis Phase 2, Winner, US Dept. of Health and Human Services & American Society of Nephrology, 2020
6. Dean's Apple Award - Outstanding Efforts and Commitment to Pharmacy Education, UCSF PharmD Degree Program, 2019
7. KidneyX Redesign Dialysis Phase 1, Winner, US Dept. of Health and Human Services & American Society of Nephrology, 2019
8. Elected Fellow of American Institute of Medical and Biological Engineering (AIMBE), American Institute of Medical and Biological Engineering (AIMBE), 2017
9. La Renon TANKER foundation For the Sake of Honour Award, Tamilnad Kidney Research Foundation (TANKER), 2017
10. Annual Home Dialyzors United (HDU) Chris Blagg Award, Home Dialyzors United (HDU), 2016
11. Innovation in Regulatory Science, Finalist, Burroughs Wellcome Fund, 2015
12. UCSF Outstanding Faculty Mentorship Award, Finalist, UCSF, 2014
13. Fellow, Applied Innovation Institute, 2013
14. Requested Nominator, Heinz Awards, 2013
15. Rising Star Award, BayBio Pantheon, 2012
16. Innovation Pathway 2.0 Award, Food and Drug Administration (FDA), 2012
17. UCSF Outstanding Faculty Mentorship Award, Finalist, University of California, San Francisco, 2012
18. mHealth Alliance Award, Vodafone Americas Foundation, 2011
19. Images of the Year Selection, Biomaterials Journal, 2009
20. Biotech Humanitarian Award Finalist, Biotechnology Industry Organization, 2009
21. Thomas G. Orr Memorial Lectureship, Southwestern Surgical Congress, 2008
22. Cleveland Clinic Innovator Award, Cleveland Clinic, 2007
23. Mentor Recognition Award, Cleveland Clinic Science Internship Program, 2006
24. Cleveland Clinic Innovator Award, Cleveland Clinic, 2005
25. Who's Who in Biotechnology, Crain's Cleveland Business, 2005
26. Ribbon Award, Outstanding Symposium Paper, MRS Fall Meeting, Materials Research Society, 2004
27. NASA Group Achievement Award, Harsh Environment MEMS, NASA, 2004
28. MIT TR100 Award, Top 100 Young Innovators, Technology Review Magazine, 2003
29. Clinical Translation Award, BioMEMS and Biomedical Nanotechnology World Meeting, 2001
30. Top 40 Under 40, Crain's Cleveland Business, 1999
31. Ruth Barber Moon Graduate Student Award, Case Western Reserve University, 1998
32. Senior Physics Prize, Mount Union College, 1992
33. William and Burdella Carl Mathematics Award, Mount Union College, 1989

Publications

Blauvelt D, Roy S. What is the feasibility of a clinical-scale and anticoagulation-free artificial placenta device? Expert Rev Med Devices. 2024 Nov 28; 1-4.
Moyer JC, Chivukula VK, Taheri-Tehrani P, Sandhu S, Blaha C, Fissell WH, Roy S. An arteriovenous mock circulatory loop and accompanying bond graph model for in vitro study of peripheral intravascular bioartificial organs. Artif Organs. 2024 Apr; 48(4):336-346.
Wilson L, Gress AF, Frassetto L, Sarathy H, Gress EA, Fissell WH, Roy S. Patient Preference Trade-offs for Next-Generation Kidney Replacement Therapies. Clin J Am Soc Nephrol. 2024 Jan 01; 19(1):76-84.
Moyer J, Wilson MW, Sorrentino TA, Santandreu A, Chen C, Hu D, Kerdok A, Porock E, Wright N, Ly J, Blaha C, Frassetto LA, Fissell WH, Vartanian SM, Roy S. Renal Embolization-Induced Uremic Swine Model for Assessment of Next-Generation Implantable Hemodialyzers. Toxins (Basel). 2023 09 04; 15(9).
Kim EJ, Chen C, Gologorsky R, Santandreu A, Torres A, Wright N, Goodin MS, Moyer J, Chui BW, Blaha C, Brakeman P, Vartanian S, Tang Q, David Humes H, Fissell WH, Roy S. Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes. Nat Commun. 2023 08 29; 14(1):4890.
Santandreu AG, Taheri-Tehrani P, Feinberg B, Torres A, Blaha C, Shaheen R, Moyer J, Wright N, Szot GL, Fissell WH, Vartanian S, Posselt A, Roy S. Characterization of human islet function in a convection-driven intravascular bioartificial pancreas. Bioeng Transl Med. 2023 Mar; 8(2):e10444.
Blauvelt DG, Chui BW, Higgins NC, Baltazar FJ, Roy S. Silicon membranes for extracorporeal life support: a comparison of design and fabrication methodologies. Biomed Microdevices. 2022 12 06; 25(1):2.
Hunter K, Larsen JA, Love HD, Evans RC, Roy S, Zent R, Harris RC, Wilson MH, Fissell WH. Inhibition of Transforming Growth Factor-β Improves Primary Renal Tubule Cell Differentiation in Long-Term Culture. Tissue Eng Part A. 2023 02; 29(3-4):102-111.
Love H, Evans R, Hunter K, Roy S, Fissell WH. Functionalizing Polyacrylamide Hydrogels for Renal Cell Culture Under Fluid Shear Stress. Tissue Eng Part A. 2022 Oct; 28(19-20):845-854.
Groth T, Stegmayr BG, Ash SR, Kuchinka J, Wieringa FP, Fissell WH, Roy S. Wearable and implantable artificial kidney devices for end-stage kidney disease treatment: Current status and review. Artif Organs. 2023 Apr; 47(4):649-666.
Conway PT, Gedney N, Roy S, Fissell WH. The Advancing American Kidney Health Initiative: The Challenge of Overcoming the Status Quo. J Am Soc Nephrol. 2022 09; 33(9):1797-1798.
Shaheen R, Gurlin RE, Gologorsky R, Blaha C, Munnangi P, Santandreu A, Torres A, Carnese P, Nair GG, Szot G, Fissell WH, Hebrok M, Roy S. Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived β cells for intravascular bioartificial pancreas applications. J Biomed Mater Res A. 2021 12; 109(12):2438-2448.
Sanger T, Chang A, Feaster W, Taraman S, Afari N, Beauregard D, Dethlefs B, Ghere T, Kabeer M, Tolomiczenko G, Billig M, Brophy J, Eskandanian K, Espinoza J, Farrugia S, Harrison M, Horvat C, Hoyen C, Koh C, Komiyama A, Nelson K, Kulkarni O, Levy R, Maher K, O'Donnell M, Ponsky T, Richmond F, Richter J, Roy S, Samir S, Suresh S, Stallworth C, Thekkedath U, Toman K, Wall J, West L, Wolff D. Opportunities for Regulatory Changes to Promote Pediatric Device Innovation in the United States: Joint Recommendations From Pediatric Innovator Roundtables. IEEE J Transl Eng Health Med. 2021; 9:4800105.
Quesada O, Shandhi MMH, Beach S, Dowling S, Tandon D, Heller J, Etemadi M, Roy S, Gonzalez Velez JM, Inan OT, Klein L. Use of Ballistocardiography to Monitor Cardiovascular Hemodynamics in Preeclampsia. Womens Health Rep (New Rochelle). 2021; 2(1):97-105.
Blauvelt DG, Abada EN, Oishi P, Roy S. Advances in extracorporeal membrane oxygenator design for artificial placenta technology. Artif Organs. 2021 Mar; 45(3):205-221.
Love H, Evans R, Humes HD, Roy S, Zent R, Harris R, Wilson M, Fissell WH. Metformin and Inhibition of Transforming Growth Factor-Beta Stimulate In Vitro Transport in Primary Renal Tubule Cells. Tissue Eng Part A. 2020 10; 26(19-20):1091-1098.
Fissell WH, Roy S. Treating the kidneys - a new era in the United States (and beyond). Nat Rev Nephrol. 2019 12; 15(12):727-728.
Hojs N, Fissell WH, Roy S. Ambulatory Hemodialysis-Technology Landscape and Potential for Patient-Centered Treatment. Clin J Am Soc Nephrol. 2020 01 07; 15(1):152-159.
Yee C, McCoy D, Yu J, Losey A, Jordan C, Moore T, Stillson C, Oh HJ, Kilbride B, Roy S, Patel A, Wilson MW, Hetts SW, ChemoFilter Consortium. Endovascular Ion Exchange Chemofiltration Device Reduces Off-Target Doxorubicin Exposure in a Hepatic Intra-arterial Chemotherapy Model. Radiol Imaging Cancer. 2019 09 27; 1(1):e190009.
Wilson MH, Veach RA, Luo W, Welch RC, Roy S, Fissell WH. Genome Engineering Renal Epithelial Cells for Enhanced Volume Transport Function. Cell Mol Bioeng. 2020 Feb; 13(1):17-26.
Gologorsky RC, Roy S. Ultrafiltration for management of fluid overload in patients with heart failure. Artif Organs. 2020 Feb; 44(2):129-139.
Love HD, Ao M, Jorgensen S, Swearingen L, Ferrell N, Evans R, Gewin L, Harris RC, Zent R, Roy S, Fissell WH. Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture. Tissue Eng Part A. 2019 07; 25(13-14):1013-1022.
Sarode DN, Roy S. In Vitro models for thrombogenicity testing of blood-recirculating medical devices. Expert Rev Med Devices. 2019 07; 16(7):603-616.
Ferrell N, Sandoval RM, Molitoris BA, Brakeman P, Roy S, Fissell WH. Application of physiological shear stress to renal tubular epithelial cells. Methods Cell Biol. 2019; 153:43-67.
Castle E, Chung P, Behfar MH, Chen M, Gao J, Chiu N, Nelson G, Roy S, Oberoi S. Compliance monitoring via a Bluetooth-enabled retainer: A prospective clinical pilot study. Orthod Craniofac Res. 2019 May; 22 Suppl 1:149-153.
Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S. Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing. J Pharmacol Exp Ther. 2019 06; 369(3):523-530.
Iqbal Z, Kim S, Moyer J, Moses W, Abada E, Wright N, Kim EJ, Park J, Fissell WH, Vartanian S, Roy S. In vitro and in vivo hemocompatibility assessment of ultrathin sulfobetaine polymer coatings for silicon-based implants. J Biomater Appl. 2019 08; 34(2):297-312.
Ferrell N, Cheng J, Miao S, Roy S, Fissell WH. Orbital Shear Stress Regulates Differentiation and Barrier Function of Primary Renal Tubular Epithelial Cells. ASAIO J. 2018 Nov/Dec; 64(6):766-772.
Rao A, Huynh E, Royston TJ, Kornblith A, Roy S. Acoustic Methods for Pulmonary Diagnosis. IEEE Rev Biomed Eng. 2019; 12:221-239.
Abada EN, Feinberg BJ, Roy S. Evaluation of silicon membranes for extracorporeal membrane oxygenation (ECMO). Biomed Microdevices. 2018 10 05; 20(4):86.
Salani M, Roy S, Fissell WH. Innovations in Wearable and Implantable Artificial Kidneys. Am J Kidney Dis. 2018 11; 72(5):745-751.
Rao A, Chu S, Batlivala N, Zetumer S, Roy S. Improved Detection of Lung Fluid With Standardized Acoustic Stimulation of the Chest. IEEE J Transl Eng Health Med. 2018; 6:3200107.
Rao A, Ruiz J, Bao C, Roy S. Tabla: A Proof-of-Concept Auscultatory Percussion Device for Low-Cost Pneumonia Detection. Sensors (Basel). 2018 Aug 16; 18(8).
Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M. Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges. Cell Stem Cell. 2018 Jun 01; 22(6):810-823.
Buck AKW, Groszek JJ, Colvin DC, Keller SB, Kensinger C, Forbes R, Karp S, Williams P, Roy S, Fissell WH. Combined In Silico and In Vitro Approach Predicts Low Wall Shear Stress Regions in a Hemofilter that Correlate with Thrombus Formation In Vivo. ASAIO J. 2018 Mar/Apr; 64(2):211-217.
Buck AKW, Goebel SG, Goodin MS, Wright NJ, Groszek JJ, Moyer J, Singh S, Bluestein D, Fissell WH, Roy S. Original article submission: Platelet stress accumulation analysis to predict thrombogenicity of an artificial kidney. J Biomech. 2018 03 01; 69:26-33.
Inan OT, Baran Pouyan M, Javaid AQ, Dowling S, Etemadi M, Dorier A, Heller JA, Bicen AO, Roy S, De Marco T, Klein L. Novel Wearable Seismocardiography and Machine Learning Algorithms Can Assess Clinical Status of Heart Failure Patients. Circ Heart Fail. 2018 01; 11(1):e004313.
Feinberg BJ, Hsiao JC, Park J, Zydney AL, Fissell WH, Roy S. Slit pores preferred over cylindrical pores for high selectivity in biomolecular filtration. J Colloid Interface Sci. 2018 May 01; 517:176-181.
Iqbal Z, Moses W, Kim S, Kim EJ, Fissell WH, Roy S. Sterilization effects on ultrathin film polymer coatings for silicon-based implantable medical devices. J Biomed Mater Res B Appl Biomater. 2018 08; 106(6):2327-2336.
Dharia A, Abada E, Feinberg B, Yeager T, Moses W, Park J, Blaha C, Wright N, Padilla B, Roy S. Silicon Micropore-Based Parallel Plate Membrane Oxygenator. Artif Organs. 2018 Feb; 42(2):166-173.
Song S, Blaha C, Moses W, Park J, Wright N, Groszek J, Fissell W, Vartanian S, Posselt AM, Roy S. Correction: An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport. Lab Chip. 2017 06 27; 17(13):2334.
Song S, Blaha C, Moses W, Park J, Wright N, Groszek J, Fissell W, Vartanian S, Posselt AM, Roy S. An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport. Lab Chip. 2017 05 16; 17(10):1778-1792.
Öberg CM, Groszek JJ, Roy S, Fissell WH, Rippe B. A distributed solute model: an extended two-pore model with application to the glomerular sieving of Ficoll. Am J Physiol Renal Physiol. 2018 06 01; 314(6):F1108-F1116.
Feinberg BJ, Hsiao JC, Park J, Zydney AL, Fissell WH, Roy S. Silicon nanoporous membranes as a rigorous platform for validation of biomolecular transport models. J Memb Sci. 2017 08 15; 536:44-51.
Song S, Yeung R, Park J, Posselt AM, Desai TA, Tang Q, Roy S. Glucose-Stimulated Insulin Response of Silicon Nanopore-Immunoprotected Islets under Convective Transport. ACS Biomater Sci Eng. 2017 Jun 12; 3(6):1051-1061.
Yeager T, Roy S. Evolution of Gas Permeable Membranes for Extracorporeal Membrane Oxygenation. Artif Organs. 2017 Aug; 41(8):700-709.
Brakeman P, Miao S, Cheng J, Lee CZ, Roy S, Fissell WH, Ferrell N. A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells. Biomicrofluidics. 2016 Nov; 10(6):064106.
Javaid AQ, Ashouri H, Dorier A, Etemadi M, Heller JA, Roy S, Inan OT. Quantifying and Reducing Motion Artifacts in Wearable Seismocardiogram Measurements During Walking to Assess Left Ventricular Health. IEEE Trans Biomed Eng. 2017 06; 64(6):1277-1286.
Behfar MH, Abada E, Sydanheimo L, Goldman K, Fleischman AJ, Gupta N, Ukkonen L, Roy S. Inductive passive sensor for intraparenchymal and intraventricular monitoring of intracranial pressure. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:1950-1954.
Kim S, Feinberg B, Kant R, Chui B, Goldman K, Park J, Moses W, Blaha C, Iqbal Z, Chow C, Wright N, Fissell WH, Zydney A, Roy S. Diffusive Silicon Nanopore Membranes for Hemodialysis Applications. PLoS One. 2016; 11(7):e0159526.
Kensinger C, Karp S, Kant R, Chui BW, Goldman K, Yeager T, Gould ER, Buck A, Laneve DC, Groszek JJ, Roy S, Fissell WH. First Implantation of Silicon Nanopore Membrane Hemofilters. ASAIO J. 2016 Jul-Aug; 62(4):491-5.
Song S, Faleo G, Yeung R, Kant R, Posselt AM, Desai TA, Tang Q, Roy S. Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport. Sci Rep. 2016 Mar 24; 6:23679.
Kim S, Heller J, Iqbal Z, Kant R, Kim EJ, Durack J, Saeed M, Do L, Hetts S, Wilson M, Brakeman P, Fissell WH, Roy S. Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy. ASAIO J. 2016 Mar-Apr; 62(2):169-75.
Song S, Roy S. Progress and challenges in macroencapsulation approaches for type 1 diabetes (T1D) treatment: Cells, biomaterials, and devices. Biotechnol Bioeng. 2016 07; 113(7):1381-402.
Harrison B, Stern L, Chung P, Etemadi M, Kwiat D, Roy S, Harrison MR, Martinez-Ferro M. MyPectus: First-in-human pilot study of remote compliance monitoring of teens using dynamic compression bracing to correct pectus carinatum. J Pediatr Surg. 2016 Apr; 51(4):608-11.
Yang J, Charif AC, Puskas JE, Phillips H, Shanahan KJ, Garsed J, Fleischman A, Goldman K, Roy S, Luebbers MT, Dombrowski SM, Luciano MG. Corrigendum to: Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating. J Mech Behav Biomed Mater. 2016 Jan; 53:463.
Etemadi M, Inan OT, Heller JA, Hersek S, Klein L, Roy S. A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables. IEEE Trans Biomed Circuits Syst. 2016 Apr; 10(2):280-8.
Swisher SL, Lin MC, Liao A, Leeflang EJ, Khan Y, Pavinatto FJ, Mann K, Naujokas A, Young D, Roy S, Harrison MR, Arias AC, Subramanian V, Maharbiz MM. Impedance sensing device enables early detection of pressure ulcers in vivo. Nat Commun. 2015 Mar 17; 6:6575.
Song S, Kim EJ, Bahney CS, Miclau T, Marcucio R, Roy S. The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells. Acta Biomater. 2015 May; 18:100-11.
Yang J, Charif AC, Puskas JE, Phillips H, Shanahan KJ, Garsed J, Fleischman A, Goldman K, Roy S, Luebbers MT, Dombrowski SM, Luciano MG. Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating. J Mech Behav Biomed Mater. 2015 May; 45:83-9.
Kim S, Fissell WH, Humes DH, Roy S. Current strategies and challenges in engineering a bioartificial kidney. Front Biosci (Elite Ed). 2015 01 01; 7(2):215-28.
Liao A, Lin MC, Ritz LC, Swisher SL, Ni D, Mann K, Khan Y, Roy S, Harrison MR, Arias AC, Subramanian V, Young D, Maharbiz MM. Impedance sensing device for monitoring ulcer healing in human patients. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:5130-3.
Wiens AD, Etemadi M, Roy S, Klein L, Inan OT. Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography. IEEE J Biomed Health Inform. 2015 Jul; 19(4):1435-42.
Chung P, Heller JA, Etemadi M, Ottoson PE, Liu JA, Rand L, Roy S. Rapid and low-cost prototyping of medical devices using 3D printed molds for liquid injection molding. J Vis Exp. 2014 Jun 27; (88):e51745.
Olorunsola OG, Kim SH, Chang R, Kuo YC, Hetts SW, Heller A, Kant R, Saeed M, Fissell WH, Roy S, Wilson MW. Imaging assessment of a portable hemodialysis device: detection of possible failure modes and monitoring of functional performance. Med Instrum (Luton). 2014 Mar 27; 2(2).
Jiang H, Chen S, Kish S, Loh L, Zhang J, Zhang X, Kwiat D, Harrison M, Roy S. Miniaturizing RFID for magnamosis. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:638-41.
Etemadi M, Hersek S, Tseng JM, Rabbani N, Heller JA, Roy S, Klein L, Inan OT. Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:5188-91.
Wiens A, Etemadi M, Klein L, Roy S, Inan OT. Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:5172-5.
Kim S, Roy S. Microelectromechanical systems and nephrology: the next frontier in renal replacement technology. Adv Chronic Kidney Dis. 2013 Nov; 20(6):516-35.
Jiang H, Zhang J, Lan D, Liou S, Shahnasser H, Fechter R, Hirose S, Harrison M, Roy S. A low-frequency versatile wireless power transfer technology for biomedical implants. IEEE Trans Biomed Circuits Syst. 2013 Aug; 7(4):526-35.
Etemadi M, Chung P, Heller JA, Liu JA, Rand L, Roy S. Towards BirthAlert--A Clinical Device Intended for Early Preterm Birth Detection. IEEE Trans Biomed Eng. 2013 Dec; 60(12):3484-93.
Kim EJ, Fleischman AJ, Muschler GF, Roy S. Response of bone marrow derived connective tissue progenitor cell morphology and proliferation on geometrically modulated microtextured substrates. Biomed Microdevices. 2013 Jun; 15(3):385-96.
Humes HD, Buffington D, Westover AJ, Roy S, Fissell WH. The bioartificial kidney: current status and future promise. Pediatr Nephrol. 2014 Mar; 29(3):343-51.
Fissell WH, Roy S, Davenport A. Achieving more frequent and longer dialysis for the majority: wearable dialysis and implantable artificial kidney devices. Kidney Int. 2013 Aug; 84(2):256-64.
Chung P, Rowe A, Etemadi M, Lee H, Roy S. Fabric-based pressure sensor array for decubitus ulcer monitoring. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:6506-9.
Etemadi M, Chung P, Heller JA, Liu J, Grossman-Kahn R, Rand L, Roy S. Novel device to trend impedance and fluorescence of the cervix for preterm birth detection. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:176-9.
Etemadi M, Heller JA, Schecter SC, Shue EH, Miniati D, Roy S. Implantable ultra-low pulmonary pressure monitoring system for fetal surgery. IEEE Trans Inf Technol Biomed. 2012 Nov; 16(6):1208-15.
Jiang H, Lan D, Lin D, Zhang J, Liou S, Shahnasser H, Shen M, Harrison M, Roy S. A feed-forward controlled AC-DC boost converter for biomedical implants. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:1675-8.
Jelin EB, Etemadi M, Encinas J, Schecter SC, Chapin C, Wu J, Guevara-Gallardo S, Nijagal A, Gonzales KD, Ferrier WT, Roy S, Miniati D. Dynamic tracheal occlusion improves lung morphometrics and function in the fetal lamb model of congenital diaphragmatic hernia. J Pediatr Surg. 2011 Jun; 46(6):1150-7.
Muthusubramaniam L, Lowe R, Fissell WH, Li L, Marchant RE, Desai TA, Roy S. Hemocompatibility of silicon-based substrates for biomedical implant applications. Ann Biomed Eng. 2011 Apr; 39(4):1296-305.
Li L, Marchant RE, Dubnisheva A, Roy S, Fissell WH. Anti-biofouling Sulfobetaine Polymer Thin Films on Silicon and Silicon Nanopore Membranes. J Biomater Sci Polym Ed. 2011; 22(1-3):91-106.
Jiang H, Lan D, Goldman K, Etemadi M, Shahnasser H, Roy S. The Responsivity of a Miniaturized Passive Implantable Wireless Pressure Sensor. Proc IEEE Radio Wirel Symp. 2011; 2011:11-14.
Ferrell N, Desai RR, Fleischman AJ, Roy S, Humes HD, Fissell WH. A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells. Biotechnol Bioeng. 2010 Nov 01; 107(4):707-16.
Ferrell N, Groszek J, Li L, Smith R, Butler RS, Zorman CA, Roy S, Fissell WH. Basal lamina secreted by MDCK cells has size- and charge-selective properties. Am J Physiol Renal Physiol. 2011 Jan; 300(1):F86-90.
Chandrana C, Talman J, Pan T, Roy S, Fleischman A. Design and analysis of MEMS based PVDF ultrasonic transducers for vascular imaging. Sensors (Basel). 2010; 10(9):8740-50.
Groszek J, Li L, Ferrell N, Smith R, Zorman CA, Hofmann CL, Roy S, Fissell WH. Molecular conformation and filtration properties of anionic Ficoll. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F752-7.
Melvin ME, Fissell WH, Roy S, Brown DL. Silicon induces minimal thromboinflammatory response during 28-day intravascular implant testing. ASAIO J. 2010 Jul-Aug; 56(4):344-8.
Chandrana C, Kharin N, Vince G, Roy S, Fleischman A. Demonstration of second-harmonic IVUS feasibility with focused broadband miniature transducers. IEEE Trans Ultrason Ferroelectr Freq Control. 2010 May; 57(5):1077-85.
Datta S, Conlisk AT, Kanani DM, Zydney AL, Fissell WH, Roy S. Characterizing the surface charge of synthetic nanomembranes by the streaming potential method. J Colloid Interface Sci. 2010 Aug 01; 348(1):85-95.
Kanani DM, Fissell WH, Roy S, Dubnisheva A, Fleischman A, Zydney AL. Permeability - Selectivity Analysis for Ultrafiltration: Effect of Pore Geometry. J Memb Sci. 2010 Mar 01; 349(1-2):405.
Jiang H, Zhang JM, Liou SS, Fechter R, Hirose S, Harrison M, Roy S. A high-power versatile wireless power transfer for biomedical implants. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:6437-40.
Fissell WH, Roy S. The implantable artificial kidney. Semin Dial. 2009 Nov-Dec; 22(6):665-70.
Kim EJ, Boehm CA, Fleischman AJ, Muschler GF, Kostov YV, Roy S. Modulating human connective tissue progenitor cell behavior on cellulose acetate scaffolds by surface microtextures. J Biomed Mater Res A. 2009 Sep 15; 90(4):1198-205.
Fissell WH, Hofmann CL, Ferrell N, Schnell L, Dubnisheva A, Zydney AL, Yurchenco PD, Roy S. Solute partitioning and filtration by extracellular matrices. Am J Physiol Renal Physiol. 2009 Oct; 297(4):F1092-100.
Kim EJ, Boehm CA, Mata A, Fleischman AJ, Muschler GF, Roy S. Post microtextures accelerate cell proliferation and osteogenesis. Acta Biomater. 2010 Jan; 6(1):160-9.
Mata A, Kim EJ, Boehm CA, Fleischman AJ, Muschler GF, Roy S. A three-dimensional scaffold with precise micro-architecture and surface micro-textures. Biomaterials. 2009 Sep; 30(27):4610-7.
Conlisk AT, Datta S, Fissell WH, Roy S. Biomolecular transport through hemofiltration membranes. Ann Biomed Eng. 2009 Apr; 37(4):722-36.
Fissell WH, Dubnisheva A, Eldridge AN, Fleischman AJ, Zydney AL, Roy S. High-Performance Silicon Nanopore Hemofiltration Membranes. J Memb Sci. 2009 Jan 05; 326(1):58-63.
Nath P, Strelnik J, Vasanji A, Moore LR, Williams PS, Zborowski M, Roy S, Fleischman AJ. Development of multistage magnetic deposition microscopy. Anal Chem. 2009 Jan 01; 81(1):43-9.
Roy S, Fleischman A, Benzel EC, Cameron BD, Ferrara L, Goel VK. Basic Science Symposium II: MEMS Technology. SAS J. 2008; 2(2):120-9.
Ferrara LA, Gordon I, Schlenk R, Coquillette M, Fleischman AJ, Roy S, Togawa D, Bauer TW, Benzel EC. In Vivo Assessment of Bone Graft/Endplate Contact Pressure in a Caprine Interbody Pseudarthrosis Model: A Preliminary Biomechanical Characterization of the Fusion Process for the Development of a Microelectromechanical Systems (MEMS) Biosensor. SAS J. 2008; 2(1):1-8.
Ferrara LA, Gordon I, Coquillette M, Milks R, Fleischman AJ, Roy S, Goel VK, Benzel EC. A preliminary biomechanical evaluation in a simulated spinal fusion model. Laboratory investigation. J Neurosurg Spine. 2007 Nov; 7(5):542-8.
Melnik K, Sun J, Fleischman A, Roy S, Zborowski M, Chalmers JJ. Quantification of magnetic susceptibility in several strains of Bacillus spores: implications for separation and detection. Biotechnol Bioeng. 2007 Sep 01; 98(1):186-92.
Fissell WH, Manley S, Dubnisheva A, Glass J, Magistrelli J, Eldridge AN, Fleischman AJ, Zydney AL, Roy S. Ficoll is not a rigid sphere. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1209-13.
Fissell WH, Fleischman AJ, Humes HD, Roy S. Development of continuous implantable renal replacement: past and future. Transl Res. 2007 Dec; 150(6):327-36.
Mata A, Boehm C, Fleischman AJ, Muschler GF, Roy S. Connective tissue progenitor cell growth characteristics on textured substrates. Int J Nanomedicine. 2007; 2(3):389-406.
Fissell WH, Manley S, Westover A, Humes HD, Fleischman AJ, Roy S. Differentiated growth of human renal tubule cells on thin-film and nanostructured materials. ASAIO J. 2006 May-Jun; 52(3):221-7.
Smiechowski MF, Lvovich VF, Roy S, Fleischman A, Fissell WH, Riga AT. Electrochemical detection and characterization of proteins. Biosens Bioelectron. 2006 Dec 15; 22(5):670-7.
Schneider T, Moore LR, Jing Y, Haam S, Williams PS, Fleischman AJ, Roy S, Chalmers JJ, Zborowski M. Continuous flow magnetic cell fractionation based on antigen expression level. J Biochem Biophys Methods. 2006 Jul 31; 68(1):1-21.
Talman JR, Fleischman AJ, Roy S. Orthogonal-coil RF probe for implantable passive sensors. IEEE Trans Biomed Eng. 2006 Mar; 53(3):538-46.
Lopez CA, Fleischman AJ, Roy S, Desai TA. Evaluation of silicon nanoporous membranes and ECM-based microenvironments on neurosecretory cells. Biomaterials. 2006 Jun; 27(16):3075-83.
Benzel EC, Kayanja M, Fleischman A, Roy S. Spine biomechanics: fundamentals and future. Clin Neurosurg. 2006; 53:98-105.
Mata A, Fleischman AJ, Roy S. Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems. Biomed Microdevices. 2005 Dec; 7(4):281-93.
Nath P, Roy S, Conlisk T, Fleischman AJ. A system for micro/nano fluidic flow diagnostics. Biomed Microdevices. 2005 Sep; 7(3):169-77.
Benzel E, Ferrara L, Roy S, Fleischman A. Micromachines in spine surgery. Spine (Phila Pa 1976). 2004 Mar 15; 29(6):601-6.
Mata A, Su X, Fleischman AJ, Roy S, Banks BA, Miller SK, Midura RJ. Osteoblast attachment to a textured surface in the absence of exogenous adhesion proteins. IEEE Trans Nanobioscience. 2003 Dec; 2(4):287-94.
Mata A, Boehm C, Fleischman AJ, Muschler G, Roy S. Growth of connective tissue progenitor cells on microtextured polydimethylsiloxane surfaces. J Biomed Mater Res. 2002 Dec 15; 62(4):499-506.
Mata A, Boehm C, Fleischman AJ, Muschler G, Roy S. Analysis of connective tissue progenitor cell behavior on polydimethylsiloxane smooth and channel micro-textures. Biomed Microdevices. 2002 Dec; 4(4):267-75.
Kotzar G, Freas M, Abel P, Fleischman A, Roy S, Zorman C, Moran JM, Melzak J. Evaluation of MEMS materials of construction for implantable medical devices. Biomaterials. 2002 Jul; 23(13):2737-50.
Benzel EC, Ferrara LA, Roy S, Fleischman AJ. Biomaterials and implantable devices: discoveries in the spine surgery arena. Clin Neurosurg. 2002; 49:209-25.