UCSF

Burlingame and Gross labs shed light on braking mechanisms in cellular signaling

How do cells that must respond rapidly and robustly to changes in the environment subsequently modulate that response so such elevated activity doesn’t prove harmful? Put another way: How do cells put the brakes on their response to external signaling in order to re-stabilize themselves?

The laboratories of School faculty members Al Burlingame, PhD, and John Gross, PhD, in collaboration with researchers at UC Berkeley, the Plant Gene Expression Center, and the Carnegie Institution for Science, have identified a novel bimolecular mechanism by which a plant often used as an experimental model, Arabidopsis, combines acceleration and restraint as its seedlings emerge from underground darkness into sunlight.

The researchers’ discovery, reported in the June 6, 2014 issue of Science, has potential implications ranging from agricultural use to cancer research. Burlingame and Gross are faculty members in the Department of Pharmaceutical Chemistry. Co-lead author Shou-Ling Xu, PhD, is a postdoctoral fellow in the department’s mass spectrometry facility.

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About the School: The UCSF School of Pharmacy is a premier graduate-level academic organization dedicated to improving health through precise therapeutics. It succeeds through innovative research, by educating PharmD health professional and PhD science students, and by caring for the therapeutics needs of patients while exploring innovative new models of patient care. The School was founded in 1872 as the first pharmacy school in the American West. It is an integral part of UC San Francisco, a leading university dedicated to promoting health worldwide.