UCSF

Deanna Kroetz, PhD

Department Chair and Professor
Jere E. Goyan Presidential Professor for the Advancement of Pharmacy
Phone: +1 415 476-1159
Fax: +1 415 514-4361
1550 4th Street, Bldg 19B, Rm 584E
UCSF Box 2911
San Francisco, CA 94158
United States

What I do

Our lab seeks to understand the molecular basis of interindividual variation in drug response and toxicity. We investigate genetic differences in chemotherapy-induced peripheral neuropathy and other cancer drug phenotypes and search for new therapeutic approaches targeting ABC transporters.

Departmental research area

My research expertise

pharmacogenomics, cancer drug toxicity, peripheral neuropathy, ABC transporters

Degrees

PhD, Pharmaceutics, University of Washington, 1990
BSc, Pharmacy, Ohio State University, 1985

Biography

The overarching goal of the Kroetz laboratory is to understand the molecular basis of interindividual variability in drug response and toxicity. Genomic association studies are used to identify genes and pathways involved in common toxicities associated with cancer therapy, including taxane-induced peripheral neuropathy and bevacizumab-induced hypertension. Functional genomic studies are then used to define the role of these genes and pathways in the dose-limiting toxicities. A second area of research is on the role of ABC transporters in drug resistance and physiologic function. Ongoing efforts include cryo-EM studies of MRP4 and investigation of MRP4 in resistance to immunotherapy.

Research keywords

  • ABC Transporters
  • paclitaxel
  • Drug-Induced Toxicity
  • pharmacogenetics
  • Peripheral Neuropathy
  • ATP-Binding Cassette Transporters
  • cancer pharmacogenetics
  • MDR
  • Peripheral Nervous System Diseases
  • antiretroviral pharmacogenetics
  • Multidrug Resistance-Associated Proteins
  • Antineoplastic Agents
  • Hydroxyeicosatetraenoic Acids
  • Polymorphism, Single Nucleotide
  • Mixed Function Oxygenases
  • Genes, MDR
  • ATP-Binding Cassette Transporters
  • paclitaxel
  • Antineoplastic Agents, Phytogenic
  • Cytochrome P-450 Enzyme System
  • Organic Anion Transporters
  • Epoxide Hydrolases
  • Aryl Hydrocarbon Hydroxylases
  • Peripheral Nervous System Diseases
  • 8,11,14-Eicosatrienoic Acid
  • Multidrug Resistance-Associated Proteins
  • pharmacogenetics

Licensure and certifications

Registered Pharmacist, Ohio, 1985