UCSF

Deanna Kroetz, PhD

Professor
Internal Advisory Committee Member
Jere E. Goyan Presidential Professor for the Advancement of Pharmacy
Phone: +1 415 476-1159
Fax: +1 415 514-4361
1550 4th Street, Bldg 19B, Rm 584E
UCSF Box 2911
San Francisco, CA 94158
United States

What I do

My research seeks to understand the contribution of genetic variation to drug toxicity, to identify genetic biomarkers that can be used to guide effective use of drugs in the treatment of cancer and HIV, and to use genetics to unravel the molecular basis of drug-induced toxicity.

Departmental research area

My research expertise

cancer therapy, HIV/AIDS, multidrug resistance, membrane transporters, toxicity

Degrees

PhD, Pharmaceutics, University of Washington, 1990
BSc, Pharmacy, Ohio State University, 1985

Biography

The overarching goal of the Kroetz laboratory is to understand the molecular basis of interindividual variability in drug response and toxicity. Genomic association studies are used to identify genes and pathways involved in common toxicities associated with cancer therapy, including taxane-induced peripheral neuropathy and bevacizumab-induced hypertension. Functional genomic studies are then used to define the role of these genes and pathways in the dose-limiting toxicities. A second area of research is on the role of ABC transporters in drug resistance and physiologic function. Ongoing efforts include cryo-EM studies of MRP4 and investigation of MRP4 in resistance to immunotherapy.

Licensure and certifications

Registered Pharmacist, Ohio, 1985