UCSF

Aashish Manglik, MD, PhD

Manglik
1700 4th Street, Rm 508C
San Francisco, CA 94158
United States

Affiliations

What I do

I am a physician-scientist interested in understanding how the human body senses and responds to external stimuli. My research focuses on the largest group of drug targets in the human body, the G protein coupled receptors. We aim to understand the most basic principles of these receptors in order to develop new medications that are both more effective and have decreased side effects.

My research expertise

G-protein-coupled receptors (GPCRs), structural biology, signaling, protein dynamics

Professional background

Biography

Our laboratory seeks to understand how cells sense and respond to their external environment. In this endeavor, we study the numerous proteins that lie at the cellular surface that enable individual cells to decipher the enormous number of stimuli that coordinate normal physiology. To gain a fundamental understanding of such transmembrane signaling processes, we use a diverse array of techniques spanning biochemical and biophysical interrogation to protein engineering. Our ultimate goal is to use these insights to discover new approaches to precisely control cellular signaling.

Research keywords

  • G protein-coupled receptor
  • GPCR
  • opioid receptors
  • signaling
  • structural biology
  • protein biophysic
  • Receptors, G-Protein-Coupled
  • Hepcidins
  • Receptors, Neurokinin-1
  • beta-Arrestins
  • Receptors, Adrenergic, beta-2
  • Antibodies, Neutralizing
  • Single-Domain Antibodies
  • GTP-Binding Proteins
  • Receptors, Opioid, mu
  • Receptors, Opioid, delta
  • Hedgehog Proteins
  • Smoothened Receptor
  • Cryoelectron Microscopy
  • Sterols
  • Spike Glycoprotein, Coronavirus