Zev Gartner, PhD

Professor
Department of Pharmaceutical Chemistry
[email protected]
Phone: +1 415 514-9962
Fax: +1 415 502-4690
600 16th Street, Rm N512E
UCSF Box 2280
San Francisco, CA 94158
United States

Links

Gartner Lab UCSF Profiles

Affiliations

Education programs

UCSF Tetrad Graduate Program
UCSF - UC Berkeley Joint Graduate Group in Bioengineering
Biophysics Graduate Program (BP)
Chemistry and Chemical Biology Graduate Program (CCB)

UCSF centers, institutes, and research programs

Quantitative Biosciences Institute (QBI)

What I do

My laboratory is working to understand how cells self-organize into tissues, how the structure of tissues help regulate cell behaviors, and how tissue structure breaks down in diseases like cancer. By understanding these processes we hope to reveal general principles contributing to cancer progression, to speed the development of new drugs, and to develop new strategies for regenerative medicine. To accomplish these goals we build, perturb, and model human tissues in vitro using techniques from the chemical, physical, and biological sciences.

Departmental research area

physical biology
chemical biology and medicinal chemistry
protein and cellular engineering

My research expertise

oligonucleotide synthesis, bioconjugation, Self-organization, Tissue Engineering, bioengineering, organoids, cell-cell interactions, Chemical Biology, single cell analysis

Professional background

Degrees

PhD, Harvard University, 2004
BS, University of California, Berkeley, 1999

Biography

The human body contains over 10 trillion cells spanning hundreds of morphologically distinct cell types. These cells must work together for our bodies to function correctly. However, it remains a mystery how such an enormous diversity of cells coordinate their behaviors.

Tissue structure - or the composition and physical arrangement of cells, extracellular matrix, and diffusible molecules - helps to coordinate cellular behaviors by organizing the flow of chemical, mechanical, and electrical information between cells. Thus, building tissue structure correctly and maintaining tissue structure over time are prerequisites for engineering functional organs and stopping the progression of diseases like cancer.

We are interested in three general questions about how tissue structure forms and functions:

(i) How does tissue structure form through the process of self-organization?
(ii) How does tissue structure help cells to arrive at collective decisions and to organize collective behaviors?
(iii) How does tissue structure breakdown during the progression of diseases like cancer?

To answer these questions we take a synthetic approach, building human tissues from the bottom-up. This approach allows us to measure and perturb the molecular and physical properties of individual cells, reconstitute them into living tissue, then observe their interactions to reveal the underlying "rules" guiding their collective behaviors. We focus primarily on the cells and tissues of the human breast, and our work incorporates experimental principles from the chemical, biological, and engineering sciences.

Research keywords

  • Cancer Biology
  • Tissue Engineering
  • Systems and Synthetic Biology
  • Chemical Biology
  • Extracellular Matrix
  • Cell Communication
  • Single-Cell Analysis
  • synthetic biology
  • microfluidics
  • cell culture techniques
  • morphogenesis
  • Embryology
  • Human Umbilical Vein Endothelial Cells
  • Mammary Glands, Human
  • Cell Adhesion
  • Tissue Engineering
  • DNA
  • Oligonucleotides
  • Organoids
1. School of Pharmacy leads in NIH funding for the 44th straight year
2. UCSF School of Pharmacy leads in NIH funding for the 43rd straight year
3. Update from the Dean: Passing the torch
4. UCSF School of Pharmacy leads in NIH funding for the 42nd straight year
5. Faculty members inducted into the Chan Zuckerberg Biohub Investigator Program
6. UCSF School of Pharmacy leads in NIH funding for the 41st straight year
7. 2019 Koda-Kimble Seed Award supports School of Pharmacy’s boldest ideas
8. Update from the Dean – March 2018
9. Cell-folding research opens door to building with biology
10. Update from the Dean - September 2017
11. Update from the Dean - March 2017
12. Gartner to co-direct new UCSF-based Center for Cellular Construction
13. Update from the Dean - Spring/Summer 2016
14. Gartner named one of Popular Science’s “Brilliant 10” of 2015
15. Update from the Dean - Spring/Summer 2015
16. Update from the Dean - Spring/Summer 2014
17. UCSF School of Pharmacy leads in NIH funding for 34th year in a row
18. Update from the Dean - Fall 2013
19. Gartner receives NIH New Innovator Award to build complex human breast tissue
20. Study builds breast tissues to track how abnormal cells affect neighbors
21. Update from the Dean - Fall/Winter 2011
22. Gartner to lead study on the interactions of cells in breast cancer
23. Update from the Dean - Fall/Winter 2009
1. Brilliant 10, Popular Science, 2015
2. New Innovator Award, NIH, 2013
3. Era of Hope Scholar Award, 2010
4. Kimmel Scholar Award, 2010
5. Sandler Opportunity Award, 2008
6. Jane Coffin Childs Postdoctoral Fellow, 2006
7. IUPAC Prize for Young Chemists "for the best Ph.D. theses in the chemical sciences.", 2005
8. Fellowship, Bristol-Myers Squibb, 2003
9. Merit Fellowship, Harvard, 2003
10. Fellowship, National Science Foundation Graduate Research, 2000
11. High Honors in Chemistry, UC Berkeley, 1999
12. Beckman Scholar, 1998

Publications

Graham AJ, Khoo MWL, Srivastava V, Viragova S, Kim H, Parekh K, Hennick KM, Bird M, Goldhammer N, Yu JZ, Morley CD, Lebel P, Kumar S, Rosenbluth JM, Nowakowski TJ, Klein O, Gómez-Sjöberg R, Gartner ZJ. MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis. bioRxiv. 2024 Oct 09.
Korotkevich E, Conrad DN, Gartner ZJ, O'Farrell PH. Selection promotes age-dependent degeneration of the mitochondrial genome. bioRxiv. 2024 Sep 28.
Winkler J, Tan W, Diadhiou CM, McGinnis CS, Abbasi A, Hasnain S, Durney S, Atamaniuc E, Superville D, Awni L, Lee JV, Hinrichs JH, Wagner PS, Singh N, Hein MY, Borja M, Detweiler AM, Liu SY, Nanjaraj A, Sitarama V, Rugo HS, Neff N, Gartner ZJ, Oliveira Pisco A, Goga A, Darmanis S, Werb Z. Single-cell analysis of breast cancer metastasis reveals epithelial-mesenchymal plasticity signatures associated with poor outcomes. J Clin Invest. 2024 Sep 03; 134(17).
Jiang J, Chen S, Tsou T, McGinnis CS, Khazaei T, Zhu Q, Park JH, Strazhnik IM, Vielmetter J, Gong Y, Hanna J, Chow ED, Sivak DA, Gartner ZJ, Thomson M. D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response. bioRxiv. 2024 Jun 04.
Huycke TR, Häkkinen TJ, Miyazaki H, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, Oria R, Weaver VM, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ. Patterning and folding of intestinal villi by active mesenchymal dewetting. Cell. 2024 Jun 06; 187(12):3072-3089.e20.
Rabadam G, Wibrand C, Flynn E, Hartoularos GC, Sun Y, Madubata C, Fragiadakis GK, Ye CJ, Kim S, Gartner ZJ, Sirota M, Neely J. Coordinated immune dysregulation in juvenile dermatomyositis revealed by single-cell genomics. JCI Insight. 2024 May 14; 9(12).
Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. Nat Cell Biol. 2024 Feb; 26(2):250-262.
Zhu Q, Conrad DN, Gartner ZJ. deMULTIplex2: robust sample demultiplexing for scRNA-seq. Genome Biol. 2024 01 30; 25(1):37.
Rabadam G, Wibrand C, Flynn E, Hartoularos GC, Sun Y, Ye CJ, Kim S, Gartner Z, Sirota M, Neely J. Coordinated immune dysregulation in Juvenile Dermatomyositis revealed by single-cell genomics. bioRxiv. 2023 Nov 10.
Reyes EA, Castillo-Azofeifa D, Rispal J, Wald T, Zwick RK, Palikuqi B, Mujukian A, Rabizadeh S, Gupta AR, Gardner JM, Boffelli D, Gartner ZJ, Klein OD. Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis. J Clin Invest. 2023 10 16; 133(20).
Caruso JA, Wang X, Murrow LM, Rodriguez CI, Chen-Tanyolac C, Vu L, Chen YY, Gascard P, Gartner ZJ, Kerlikowske K, Tlsty TD. Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity. Proc Natl Acad Sci U S A. 2023 10 17; 120(42):e2303774120.
Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. bioRxiv. 2023 Sep 22.
Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ. Patterning and folding of intestinal villi by active mesenchymal dewetting. bioRxiv. 2023 Aug 15.
Srivastava V, Hu JL, Garbe JC, Veytsman B, Shalabi SF, Yllanes D, Thomson M, LaBarge MA, Huber G, Gartner ZJ. Configurational entropy is an intrinsic driver of tissue structural heterogeneity. bioRxiv. 2023 Jul 02.
Adler FR, Anderson ARA, Bhushan A, Bogdan P, Bravo-Cordero JJ, Brock A, Chen Y, Cukierman E, DelGiorno KE, Denis GV, Ferrall-Fairbanks MC, Gartner ZJ, Germain RN, Gordon DM, Hunter G, Jolly MK, Karacosta LG, Mythreye K, Katira P, Kulkarni RP, Kutys ML, Lander AD, Laughney AM, Levine H, Lou E, Lowenstein PR, Masters KS, Pe'er D, Peyton SR, Platt MO, Purvis JE, Quon G, Richer JK, Riddle NC, Rodriguez A, Snyder JC, Lee Szeto G, Tomlin CJ, Yanai I, Zervantonakis IK, Dueck H. Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. Cell Syst. 2023 04 19; 14(4):252-257.
Zhu Q, Conrad DN, Gartner ZJ. deMULTIplex2: robust sample demultiplexing for scRNA-seq. bioRxiv. 2023 Apr 12.
Clark IC, Fontanez KM, Meltzer RH, Xue Y, Hayford C, May-Zhang A, D'Amato C, Osman A, Zhang JQ, Hettige P, Ishibashi JSA, Delley CL, Weisgerber DW, Replogle JM, Jost M, Phong KT, Kennedy VE, Peretz CAC, Kim EA, Song S, Karlon W, Weissman JS, Smith CC, Gartner ZJ, Abate AR. Microfluidics-free single-cell genomics with templated emulsification. Nat Biotechnol. 2023 Nov; 41(11):1557-1566.
Cabral KA, Srivastava V, Graham AJ, Coyle MC, Stashko C, Weaver V, Gartner ZJ. Programming the Self-Organization of Endothelial Cells into Perfusable Microvasculature. Tissue Eng Part A. 2023 02; 29(3-4):80-92.
Kwak M, Southard KM, Kim WR, Lin A, Kim NH, Gopalappa R, Lee HJ, An M, Choi SH, Jung Y, Noh K, Farlow J, Georgakopoulos A, Robakis NK, Kang MK, Kutys ML, Seo D, Kim HH, Kim YH, Cheon J, Gartner ZJ, Jun YW. Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling. Nat Cell Biol. 2022 12; 24(12):1739-1753.
Kummerlowe C, Mwakamui S, Hughes TK, Mulugeta N, Mudenda V, Besa E, Zyambo K, Shay JES, Fleming I, Vukovic M, Doran BA, Aicher TP, Wadsworth MH, Bramante JT, Uchida AM, Fardoos R, Asowata OE, Herbert N, Yilmaz ÖH, Kløverpris HN, Garber JJ, Ordovas-Montañes J, Gartner ZJ, Wallach T, Shalek AK, Kelly P. Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation. Sci Transl Med. 2022 08 31; 14(660):eabi8633.
Louis B, Tewary M, Bremer AW, Philippeos C, Negri VA, Zijl S, Gartner ZJ, Schaffer DV, Watt FM. A reductionist approach to determine the effect of cell-cell contact on human epidermal stem cell differentiation. Acta Biomater. 2022 09 15; 150:265-276.
Murrow LM, Weber RJ, Caruso JA, McGinnis CS, Phong K, Gascard P, Rabadam G, Borowsky AD, Desai TA, Thomson M, Tlsty T, Gartner ZJ. Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution. Cell Syst. 2022 08 17; 13(8):644-664.e8.
Beck LE, Lee J, Coté C, Dunagin MC, Lukonin I, Salla N, Chang MK, Hughes AJ, Mornin JD, Gartner ZJ, Liberali P, Raj A. Systematically quantifying morphological features reveals constraints on organoid phenotypes. Cell Syst. 2022 07 20; 13(7):547-560.e3.
Yang D, Jones MG, Naranjo S, Rideout WM, Min KHJ, Ho R, Wu W, Replogle JM, Page JL, Quinn JJ, Horns F, Qiu X, Chen MZ, Freed-Pastor WA, McGinnis CS, Patterson DM, Gartner ZJ, Chow ED, Bivona TG, Chan MM, Yosef N, Jacks T, Weissman JS. Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Cell. 2022 05 26; 185(11):1905-1923.e25.
Su-Feher L, Rubin AN, Silberberg SN, Catta-Preta R, Lim KJ, Ypsilanti AR, Zdilar I, McGinnis CS, McKinsey GL, Rubino TE, Hawrylycz MJ, Thompson C, Gartner ZJ, Puelles L, Zeng H, Rubenstein JLR, Nord AS. Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2108760119.
Winkler J, Liu P, Phong K, Hinrichs JH, Ataii N, Williams K, Hadler-Olsen E, Samson S, Gartner ZJ, Fisher S, Werb Z. Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome. Proc Natl Acad Sci U S A. 2022 03 15; 119(11):e2115308119.
Adam Officer, Andre Dempsey, Farnaz Hasteh, Michal Slyper, Asa Segerstolpe, Joanna Klughammer, Judit Jane-Valbuena, Orit Rozenblatt-Rosen, Lyndsay Murrow, Zev Gartner, Aviv Regev, Christina Yau, Pablo Tamayo, Olivier Harismendy. Abstract P5-06-02: A gene expression meta-analysis identifies microenvironment differences in cellular composition and cell-cell interactions associated with breast cancer invasion. Cancer Research. 2022 Feb 15; 82(4_Supplement):p5-06-02-p5-06-02.
Huycke TR, Gartner ZJ. Setting boundaries for tissue patterning. Science. 2022 Jan 07; 375(6576):26-27.
Kim SC, Haliburton JR, Gartner ZJ, Abate AR. Single-Cell Protein Profiling by Microdroplet Barcoding and Next-Generation Sequencing. Methods Mol Biol. 2022; 2386:101-111.
Minsuk Kwak, Kaden Southard, Woon Ryoung Kim, Annie Lin, Nam Hyeong Kim, Ramu Gopalappa, Minji An, Hyun Jung Lee, Seo Hyun Choi, Justin Farlow, Anastasios Georgakopoulos, Nikolaos Robakis, Min Kang, Matthew Kutys, Daeha Seo, Hyongbum Henry Kim, Yong Ho Kim, Jinwoo Cheon, Zev Gartner, Young-wook Jun. Membrane compartmentalization by adherens junctions creates a spatial switch for Notch signaling and function. . 2021 Nov 1.
Popova G, Soliman SS, Kim CN, Keefe MG, Hennick KM, Jain S, Li T, Tejera D, Shin D, Chhun BB, McGinnis CS, Speir M, Gartner ZJ, Mehta SB, Haeussler M, Hengen KB, Ransohoff RR, Piao X, Nowakowski TJ. Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids. Cell Stem Cell. 2021 12 02; 28(12):2153-2166.e6.
Thibodeau A, Eroglu A, McGinnis CS, Lawlor N, Nehar-Belaid D, Kursawe R, Marches R, Conrad DN, Kuchel GA, Gartner ZJ, Banchereau J, Stitzel ML, Cicek AE, Ucar D. AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data. Genome Biol. 2021 09 01; 22(1):252.
Kindberg AA, Srivastava V, Muncie JM, Weaver VM, Gartner ZJ, Bush JO. EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts. J Cell Biol. 2021 06 07; 220(6).
Huang L, Desai R, Conrad DN, Leite NC, Akshinthala D, Lim CM, Gonzalez R, Muthuswamy LB, Gartner Z, Muthuswamy SK. Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids. Cell Stem Cell. 2021 06 03; 28(6):1090-1104.e6.
Lenne PF, Munro E, Heemskerk I, Warmflash A, Bocanegra-Moreno L, Kishi K, Kicheva A, Long Y, Fruleux A, Boudaoud A, Saunders TE, Caldarelli P, Michaut A, Gros J, Maroudas-Sacks Y, Keren K, Hannezo E, Gartner ZJ, Stormo B, Gladfelter A, Rodrigues A, Shyer A, Minc N, Maître JL, Di Talia S, Khamaisi B, Sprinzak D, Tlili S. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Phys Biol. 2021 04 14; 18(4).
Hernandez-Lopez RA, Yu W, Cabral KA, Creasey OA, Lopez Pazmino MDP, Tonai Y, De Guzman A, Mäkelä A, Saksela K, Gartner ZJ, Lim WA. T cell circuits that sense antigen density with an ultrasensitive threshold. Science. 2021 03 12; 371(6534):1166-1171.
Cabral KA, Patterson DM, Scheideler OJ, Cole R, Abate AR, Schaffer DV, Sohn LL, Gartner ZJ. Simple, Affordable, and Modular Patterning of Cells using DNA. J Vis Exp. 2021 02 24; (168).
Katelyn A. Cabral, David M. Patterson, Olivia J. Scheideler, Russell Cole, Adam R. Abate, David V. Schaffer, Lydia L. Sohn, Zev J. Gartner. Simple, Affordable, and Modular Patterning of Cells using DNA. Journal of Visualized Experiments. 2021 Feb 24; (168).
Zhang JQ, Siltanen CA, Dolatmoradi A, Sun C, Chang KC, Cole RH, Gartner ZJ, Abate AR. High diversity droplet microfluidic libraries generated with a commercial liquid spotter. Sci Rep. 2021 02 23; 11(1):4351.
Martyn I, Gartner ZJ. Expanding the boundaries of synthetic development. Dev Biol. 2021 06; 474:62-70.
Vasudha Srivastava, Jennifer L. Hu, James C. Garbe, Martha R. Stampfer, Mark A. LaBarge, Matthew Thomson, Zev J. Gartner. Identifying Enthalpic Barriers to Entropically-Driven Structural Disruption in Breast Cancers. Biophysical Journal. 2021 Feb 1; 120(3):196a.
McGinnis CS, Siegel DA, Xie G, Hartoularos G, Stone M, Ye CJ, Gartner ZJ, Roan NR, Lee SA. No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells. BMC Biol. 2021 01 20; 19(1):10.
Gartner ZJ, Hu JL. Guiding tissue-scale self-organization. Nat Mater. 2021 01; 20(1):2-3.
Juliane Winkler, Weilun Tan, Christopher McGinnis, Zev Gartner, Spyros Darmanis, Zena Werb. Abstract 351: Alterations in immune cell signatures during breast cancer metastasis at single cell resolution. Cancer Research. 2020 Aug 15; 80(16_Supplement):351-351.
Hu KH, Eichorst JP, McGinnis CS, Patterson DM, Chow ED, Kersten K, Jameson SC, Gartner ZJ, Rao AA, Krummel MF. ZipSeq: barcoding for real-time mapping of single cell transcriptomes. Nat Methods. 2020 08; 17(8):833-843.
Srivastava V, Huycke TR, Phong KT, Gartner ZJ. Organoid models for mammary gland dynamics and breast cancer. Curr Opin Cell Biol. 2020 10; 66:51-58.
OLIVIA A. CREASEY, JULIE B. SNEDDON, ZEV J. GARTNER. 2063-P: Quantitative Analysis of Human and Mouse Islet Tissue Structure. Diabetes. 2020 Jun 1; 69(Supplement 1):2063-p.
Jesse Q. Zhang, Kai-Chun Chang, Leqian Liu, Zev J. Gartner, Adam R. Abate. High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing. Journal of Visualized Experiments. 2020 May 21; (159).
Zhang JQ, Chang KC, Liu L, Gartner ZJ, Abate AR. High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing. J Vis Exp. 2020 05 21; (159).
Zhang JQ, Siltanen CA, Liu L, Chang KC, Gartner ZJ, Abate AR. Linked optical and gene expression profiling of single cells at high-throughput. Genome Biol. 2020 02 24; 21(1):49.
Murrow LM, Gartner ZJ. Balancing Act: Cell Polarity and Shape Compete to Ensure Robust Development. Dev Cell. 2019 12 02; 51(5):545-547.
Harel ET, Drake PM, Barfield RM, Lui I, Farr-Jones S, Van't Veer L, Gartner ZJ, Green EM, Lourenço AL, Cheng Y, Hann BC, Rabuka D, Craik CS. Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer. Antibodies (Basel). 2019 Nov 05; 8(4).
Gartner Z, Hughes A. Getting the measure of living biomaterials. Nature. 2019 08; 572(7767):38-39.
McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ. MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. Nat Methods. 2019 07; 16(7):619-626.
OLIVIA A. CREASEY, DANIEL ELNATAN, JULIE B. SNEDDON, ZEV J. GARTNER. 2151-P: Quantification of Tissue Structure in Human and Mouse Islets. Diabetes. 2019 Jun 1; 68(Supplement 1):2151-p.
Lehmann R, Lee CM, Shugart EC, Benedetti M, Charo RA, Gartner Z, Hogan B, Knoblich J, Nelson CM, Wilson KM. Human organoids: a new dimension in cell biology. Mol Biol Cell. 2019 05 01; 30(10):1129-1137.
McGinnis CS, Murrow LM, Gartner ZJ. DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors. Cell Syst. 2019 04 24; 8(4):329-337.e4.
Krummel MF, Mahale JN, Uhl LFK, Hardison EA, Mujal AM, Mazet JM, Weber RJ, Gartner ZJ, Gérard A. Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):11585-11590.
Gruber TD, Krishnamurthy C, Grimm JB, Tadross MR, Wysocki LM, Gartner ZJ, Lavis LD. Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair. ACS Chem Biol. 2018 10 19; 13(10):2888-2896.
Hughes AJ, Mornin JD, Biswas SK, Beck LE, Bauer DP, Raj A, Bianco S, Gartner ZJ. Quanti.us: a tool for rapid, flexible, crowd-based annotation of images. Nat Methods. 2018 08; 15(8):587-590.
Siltanen CA, Cole RH, Poust S, Chao L, Tyerman J, Kaufmann-Malaga B, Ubersax J, Gartner ZJ, Abate AR. An Oil-Free Picodrop Bioassay Platform for Synthetic Biology. Sci Rep. 2018 05 21; 8(1):7913.
Kim J, Han S, Lei A, Miyano M, Bloom J, Srivastava V, Stampfer MM, Gartner ZJ, LaBarge MA, Sohn LL. Characterizing cellular mechanical phenotypes with mechano-node-pore sensing. Microsyst Nanoeng. 2018; 4.
Liang SI, van Lengerich B, Eichel K, Cha M, Patterson DM, Yoon TY, von Zastrow M, Jura N, Gartner ZJ. Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras. Cell Rep. 2018 03 06; 22(10):2593-2600.
Hughes AJ, Miyazaki H, Coyle MC, Zhang J, Laurie MT, Chu D, Vavrušová Z, Schneider RA, Klein OD, Gartner ZJ. Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme. Dev Cell. 2018 01 22; 44(2):165-178.e6.
Hu JL, Todhunter ME, LaBarge MA, Gartner ZJ. Opportunities for organoids as new models of aging. J Cell Biol. 2018 01 02; 217(1):39-50.
Kim JW, Seo D, Lee JU, Southard KM, Lim Y, Kim D, Gartner ZJ, Jun YW, Cheon J. Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles. Nat Protoc. 2017 Sep; 12(9):1871-1889.
Cole RH, Tang SY, Siltanen CA, Shahi P, Zhang JQ, Poust S, Gartner ZJ, Abate AR. Printed droplet microfluidics for on demand dispensing of picoliter droplets and cells. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8728-8733.
Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner ZJ, Jun YW. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell. 2017 06 15; 169(7):1357.
Gartner ZJ, Prescher JA, Lavis LD. Unraveling cell-to-cell signaling networks with chemical biology. Nat Chem Biol. 2017 05 17; 13(6):564-568.
Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Cell. 2017 03 23; 169(1):108-119.e20.
Murrow LM, Weber RJ, Gartner ZJ. Dissecting the stem cell niche with organoid models: an engineering-based approach. Development. 2017 03 15; 144(6):998-1007.
Weber RJ, Desai TA, Gartner ZJ. Non-autonomous cell proliferation in the mammary gland and cancer. Curr Opin Cell Biol. 2017 04; 45:55-61.
Shahi P, Kim SC, Haliburton JR, Gartner ZJ, Abate AR. Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding. Sci Rep. 2017 03 14; 7:44447.
E. Harel, S. Liang, S. Brain, Z. Gartner, L. Van't Veer, C. Craik. 192 Diagnosis and therapy of aggressive breast cancers by targeting urokinase receptor. European Journal of Cancer. 2016 Dec 1; 69:s68.
Ouyang A, Cerchiari AE, Tang X, Liebenberg E, Alliston T, Gartner ZJ, Lotz JC. Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells. J Orthop Res. 2017 01; 35(1):61-73.
Weber RJ, Cerchiari AE, Delannoy LS, Garbe JC, LaBarge MA, Desai TA, Gartner ZJ. Rapid Organoid Reconstitution by Chemical Micromolding. ACS Biomater Sci Eng. 2016 Nov 14; 2(11):1851-1855.
Todhunter ME, Weber RJ, Farlow J, Jee NY, Cerchiari AE, Gartner ZJ. Fabrication of 3-D Reconstituted Organoid Arrays by DNA-Programmed Assembly of Cells (DPAC). Curr Protoc Chem Biol. 2016 09 13; 8(3):147-178.
Cerchiari AE, Samy KE, Todhunter ME, Schlesinger E, Henise J, Rieken C, Gartner ZJ, Desai TA. Probing the luminal microenvironment of reconstituted epithelial microtissues. Sci Rep. 2016 09 13; 6:33148.
Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner ZJ, Jun YW. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell. 2016 Jun 02; 165(6):1507-1518.
Cole RH, Gartner ZJ, Abate AR. Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers. J Vis Exp. 2016 05 05; (111).
Russell H. Cole, Zev J. Gartner, Adam R. Abate. Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers. Journal of Visualized Experiments. 2016 May 5; (111).
Coyle M, Hu J, Gartner Z. Mysteries in a Minimal Genome. ACS Cent Sci. 2016 May 25; 2(5):274-7.
Chen S, Bremer AW, Scheideler OJ, Na YS, Todhunter ME, Hsiao S, Bomdica PR, Maharbiz MM, Gartner ZJ, Schaffer DV. Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities. Nat Commun. 2016 Jan 12; 7:10309.
Broaders KE, Cerchiari AE, Gartner ZJ. Coupling between apical tension and basal adhesion allow epithelia to collectively sense and respond to substrate topography over long distances. Integr Biol (Camb). 2015 Dec; 7(12):1611-21.
Todhunter ME, Jee NY, Hughes AJ, Coyle MC, Cerchiari A, Farlow J, Garbe JC, LaBarge MA, Desai TA, Gartner ZJ. Programmed synthesis of three-dimensional tissues. Nat Methods. 2015 Oct; 12(10):975-81.
Cole RH, de Lange N, Gartner ZJ, Abate AR. Compact and modular multicolour fluorescence detector for droplet microfluidics. Lab Chip. 2015 Jul 07; 15(13):2754-8.
Cerchiari AE, Garbe JC, Jee NY, Todhunter ME, Broaders KE, Peehl DM, Desai TA, LaBarge MA, Thomson M, Gartner ZJ. A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2287-92.
Cerchiari A, Garbe JC, Todhunter ME, Jee NY, Pinney JR, LaBarge MA, Desai TA, Gartner ZJ. Formation of spatially and geometrically controlled three-dimensional tissues in soft gels by sacrificial micromolding. Tissue Eng Part C Methods. 2015 Jun; 21(6):541-7.
Weber RJ, Liang SI, Selden NS, Desai TA, Gartner ZJ. Efficient targeting of fatty-acid modified oligonucleotides to live cell membranes through stepwise assembly. Biomacromolecules. 2014 Dec 08; 15(12):4621-6.
Daeha Seo, Justin Farlow, Kade Southard, Young-wook Jun, Zev J. Gartner. Production and Targeting of Monovalent Quantum Dots. Journal of Visualized Experiments. 2014 Oct 23; (92).
Seo D, Farlow J, Southard K, Jun YW, Gartner ZJ. Production and targeting of monovalent quantum dots. J Vis Exp. 2014 Oct 23; (92):e52198.
Liang SI, McFarland JM, Rabuka D, Gartner ZJ. A modular approach for assembling aldehyde-tagged proteins on DNA scaffolds. J Am Chem Soc. 2014 Aug 06; 136(31):10850-3.
Rosenblatt J, Gartner Z. Cells: Shaping tissues and organs. Mol Biol Cell. 2014 Mar; 25(6):730.
Daeha Seo, Jiwook Kim, Justin Farlow, Hyunjung Lee, Paul Alivisatos, Jinwoo Cheon, Zev Gartner, Young-wook Jun. Regulating Spatiotemporal Dynamics of Notch Signaling in Live Cells via Magnetoplasmonic Nanoprobes. Biophysical Journal. 2014 Jan 1; 106(2):224a.
Farlow J, Seo D, Broaders KE, Taylor MJ, Gartner ZJ, Jun YW. Formation of targeted monovalent quantum dots by steric exclusion. Nat Methods. 2013 Dec; 10(12):1203-5.
Sogi KM, Gartner ZJ, Breidenbach MA, Appel MJ, Schelle MW, Bertozzi CR. Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging. PLoS One. 2013; 8(6):e65080.
Liu JS, Gartner ZJ. Directing the assembly of spatially organized multicomponent tissues from the bottom up. Trends Cell Biol. 2012 Dec; 22(12):683-91.
Liu JS, Farlow JT, Paulson AK, Labarge MA, Gartner ZJ. Programmed cell-to-cell variability in Ras activity triggers emergent behaviors during mammary epithelial morphogenesis. Cell Rep. 2012 Nov 29; 2(5):1461-70.
Onoe H, Hsiao SC, Douglas ES, Gartner ZJ, Bertozzi CR, Francis MB, Mathies RA. Cellular microfabrication: observing intercellular interactions using lithographically-defined DNA capture sequences. Langmuir. 2012 May 29; 28(21):8120-6.
Selden NS, Todhunter ME, Jee NY, Liu JS, Broaders KE, Gartner ZJ. Chemically programmed cell adhesion with membrane-anchored oligonucleotides. J Am Chem Soc. 2012 Jan 18; 134(2):765-8.
Hsiao SC, Shum BJ, Onoe H, Douglas ES, Gartner ZJ, Mathies RA, Bertozzi CR, Francis MB. Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir. 2009 Jun 16; 25(12):6985-91.
Gartner ZJ, Bertozzi CR. Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4606-10.
Chen X, Wu P, Rousseas M, Okawa D, Gartner Z, Zettl A, Bertozzi CR. Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells. J Am Chem Soc. 2009 Jan 28; 131(3):890-1.
Zev J. Gartner. Evolutionary approaches for the discovery of functional synthetic small molecules. Pure and Applied Chemistry. 2006 Jan 1; 78(1):1-14.
Gartner ZJ, Tse BN, Grubina R, Doyon JB, Snyder TM, Liu DR. DNA-templated organic synthesis and selection of a library of macrocycles. Science. 2004 Sep 10; 305(5690):1601-5.
Buskirk AR, Ong YC, Gartner ZJ, Liu DR. Directed evolution of ligand dependence: small-molecule-activated protein splicing. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10505-10.
Li X, Gartner ZJ, Tse BN, Liu DR. Translation of DNA into synthetic N-acyloxazolidines. J Am Chem Soc. 2004 Apr 28; 126(16):5090-2.
Zev J. Gartner, Rozalina Grubina, Christopher T. Calderone, David R. Liu. Two Enabling Architectures for DNA-Templated Organic Synthesis. Angewandte Chemie. 2003 Mar 28; 115(12):1408-1413.
Gartner ZJ, Grubina R, Calderone CT, Liu DR. Two enabling architectures for DNA-templated organic synthesis. Angew Chem Int Ed Engl. 2003 Mar 28; 42(12):1370-5.
Christopher T. Calderone, James W. Puckett, Zev J. Gartner, David R. Liu. Directing Otherwise Incompatible Reactions in a Single Solution by Using DNA-Templated Organic Synthesis. Angewandte Chemie. 2002 Nov 4; 114(21):4278-4282.
Calderone CT, Puckett JW, Gartner ZJ, Liu DR. Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis. Angew Chem Int Ed Engl. 2002 Nov 04; 41(21):4104-8.
Gartner ZJ, Kanan MW, Liu DR. Multistep small-molecule synthesis programmed by DNA templates. J Am Chem Soc. 2002 Sep 04; 124(35):10304-6.
Zev J. Gartner, Matthew W. Kanan, David R. Liu. Expanding the Reaction Scope of DNA-Templated Synthesis . Angewandte Chemie. 2002 May 17; 114(10):1874-1878.
Gartner ZJ, Kanan MW, Liu DR. Expanding the reaction scope of DNA-templated synthesis. Angew Chem Int Ed Engl. 2002 May 17; 41(10):1796-800.
Zev J. Gartner, David R. Liu. ChemInform Abstract: The Generality of DNA-Templated Synthesis as a Basis for Evolving Non-Natural Small Molecules. ChemInform. 2001 Oct 30; 32(44):no-no.
Gartner ZJ, Liu DR. The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules. J Am Chem Soc. 2001 Jul 18; 123(28):6961-3.