Zev Gartner, PhD

Phone: +1 415 514-9962
Fax: +1 415 502-4690
600 16th St, Rm N512E
UCSF Box 2280
San Francisco, CA 94158
United States

What I do

My laboratory is working to understand how cells self-organize into tissues, how the structure of tissues help regulate cell behaviors, and how tissue structure breaks down in diseases like cancer. By understanding these processes we hope to reveal general principles contributing to cancer progression, to speed the development of new drugs, and to develop new strategies for regenerative medicine. To accomplish these goals we build, perturb, and model human tissues in vitro using techniques from the chemical, physical, and biological sciences.

My research expertise

oligonucleotide synthesis, bioconjugation, Self-organization, Tissue Engineering, bioengineering, organoids, cell-cell interactions, Chemical Biology, single cell analysis

Professional background


The human body contains over 10 trillion cells spanning hundreds of morphologically distinct cell types. These cells must work together for our bodies to function correctly. However, it remains a mystery how such an enormous diversity of cells coordinate their behaviors.

Tissue structure - or the composition and physical arrangement of cells, extracellular matrix, and diffusible molecules - helps to coordinate cellular behaviors by organizing the flow of chemical, mechanical, and electrical information between cells. Thus, building tissue structure correctly and maintaining tissue structure over time are prerequisites for engineering functional organs and stopping the progression of diseases like cancer.

We are interested in three general questions about how tissue structure forms and functions:

(i) How does tissue structure form through the process of self-organization?
(ii) How does tissue structure help cells to arrive at collective decisions and to organize collective behaviors?
(iii) How does tissue structure breakdown during the progression of diseases like cancer?

To answer these questions we take a synthetic approach, building human tissues from the bottom-up. This approach allows us to measure and perturb the molecular and physical properties of individual cells, reconstitute them into living tissue, then observe their interactions to reveal the underlying "rules" guiding their collective behaviors. We focus primarily on the cells and tissues of the human breast, and our work incorporates experimental principles from the chemical, biological, and engineering sciences.

Research keywords

  • Cancer Biology
  • Tissue Engineering
  • Systems and Synthetic Biology
  • Chemical Biology
  • Extracellular Matrix
  • Cell Communication
  • Single-Cell Analysis
  • synthetic biology
  • microfluidics
  • cell culture techniques
  • morphogenesis
  • Embryology
  • Human Umbilical Vein Endothelial Cells
  • Mammary Glands, Human
  • Cell Adhesion
  • Tissue Engineering
  • DNA
  • Oligonucleotides
  • Organoids