My research seeks to inform novel therapeutic strategies to cure HIV through better understanding of pharmacokinetics and pharmacodynamics of individual and combinations of candidate drugs. Based out of the UCSF Drug Research Unit (DRU), I work with a multidisciplinary team of clinicians-scientists...
I am interested in building proteins in living cells using new amino acids. By designing novel properties into the new amino acids, my lab probes biological processes in their natural settings and engineer unique biomolecules to understand mechanisms of cellular function and to develop new...
Our group investigates how drugs affect entire networks of proteins in the body at once to achieve their therapeutic effects, via computational predictions paired with experimental testing.
Biophysicist James Fraser, PhD, has been named a 2014 Searle Scholar. His laboratory will be awarded $300,000 in funding over the next three years to support his research into more accurately and precisely describing the ways that protein molecules change shape to carry out the functions of life in...
My research focuses on computational methods for improving drug discovery. I was formally trained as a computer scientist and made a transition from applied defense research to the biomedical arena in a series of Bay Area startups.
I am a biophysicist. My research is focused on discovering the macromolecular structure and dynamics of proteins—defining conformational states essential for function and understanding transitions between these states.
My research seeks to invent approaches to engineer new biological functions at multiple scales, ranging from atomic details to macromolecular machines to cellular processes. By building new functions through a combination of computational design and experimental engineering, I also hope to learn...
My research interests focus on the development of state of the art methodologies in mass spectrometry for use in advancing our global knowledge of human biology, specifically the dynamic, epigenetic modulation and regulation of the proteome.
Our lab develops new methods for drug discovery, adopting two strategies to do so. On the one hand, we reduce biology to its molecular components, and seek to change how these fit together using synthetic molecules we design. On the other hand, we investigate how the biological molecules operate...
