William DeGrado, PhD

Phone: +1 415 476-9679
Fax: +1 415 502-4690
555 Mission Bay Blvd South, Rm 452V
UCSF Box 3122
San Francisco, CA 94158
United States

Educational programs

UCSF centers, institutes, and research programs

External affiliations

What I do

My research focuses on small molecule and protein design as an approach to understanding macromolecule structure and function.

My research expertise

pharmacological inhibition, channel formation, protein engineering


PhD, Chemistry, University of Chicago, 1981
BS, Chemistry, Kalamazoo College, 1977


One research interest is in the de novo design, in which one designs proteins or drugs beginning from first principles. This approach critically tests our understanding of protein folding and function, while also laying the groundwork for the design of molecules with properties unprecedented in nature.

Research keywords

  • Protein engineering
  • protein folding
  • Membrane Proteins
  • Protons
  • Amino Acid Sequence
  • Metalloproteins
  • Secondary Protein Structure
  • Protein Conformation
  • Molecular Models
  • proteins
  • Peptides
  • Viral Matrix Proteins
  • amantadine
  • Influenza A virus
  • Platelet Glycoprotein GPIIb-IIIa Complex