Michelle Arkin, PhD

Susan Merrell
Phone: +1 415 514-4313
Fax: +1 415 514-4504
600 16th St, Rm S512D
UCSF Box 2552
San Francisco, CA 94158
United States

Educational programs

UCSF centers, institutes, and research programs

What I do

My research focuses on the development of drug-like molecules that alter important biological processes. These molecules will help us understand human biology and may lead to the design of new drugs.

My research expertise

protein-protein interaction (PPI), allostery, enzymology, fragment-based lead discovery, neglected tropical diseases, neurodegeneration, oncology, high-throughput screening (HTS)


PhD, Chemistry, California Institute of Technology (Caltech)
BA, Chemistry, Bryn Mawr College


Michelle’s lab develops innovative approaches to screen for chemical tools and drug leads, using biophysical approaches like fragment-based drug discovery and biological approaches including high-content imaging with primary cells and organisms. Our goal is to demonstrate ‘druggability’ of new target classes and to use our compounds to discover new targets for drug discovery. Areas of interest include protein-protein interactions, allosteric and scaffolding sites in enzymes, and orphan and neglected diseases. Michelle is Associate Director of the Small Molecule Discovery Center, a collaborative research and core lab that includes a high-throughput screening facility (smdc.ucsf.edu).