Jim Wells, PhD

Harry Wm. and Diana V. Hind Distinguished Professor of Pharmaceutical Sciences I

What I do

My research focuses on developing enabling technologies for protein engineering and drug discovery to understand biology and pave roads to therapeutics.

My research expertise

Chemical Biology, systems pharmacology, Protein engineering, apoptosis and differentiation, enabling technologies, protease, kinase and UPS signaling, Proteomics, caspases

Professional background


James "Jim" Wells focuses on understanding and modulating signaling processes in human cells through protein and small molecule design. His lab seeks activators as well as inhibitors of signaling molecules, including proteases and kinases, and uses them to study the consequences of triggering specific nodes of signaling circuits. He is especially interested in the inter-protein circuitry of pathways involved in cell death and inflammation, and the intra-protein allosteric circuitry that governs how distant functional sites in one protein communicate.

Research keywords

  • proteome
  • antibodies
  • Proteomics
  • Growth Hormone
  • Protein engineering
  • Subtilisins
  • Peptide Synthases
  • Proteolysis
  • Peptide Library
  • Caspase 3
  • caspases
  • apoptosis
  • Receptors, Somatotropin
  • Spike Glycoprotein, Coronavirus
  • Allosteric Site