Categories: Research

Study discovers why leading gout medication is ineffective for many

Tue Jul 14, 2015
crystals
Bobjgalindo
, CC BY-SA 3.0
, GFDL

Spiked rods of uric acid crystals from synovial fluid photographed under a microscope with polarized light. In patients with gout, such crystals can accumulate in the joints, causing pain and inflammation.

Allopurinol, the first-choice medication for treating gout—an excruciatingly painful condition that is the most common form of inflammatory arthritis, afflicts more than eight million Americans, and is on the rise worldwide—is not fully effective in more than half of patients.

Notable publications

Tue Jun 30, 2015
Altschuler


GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.
Thorne CA, Wichaidit C, Coster AD, Posner BA, Wu LF, Altschuler SJ. Nat Chem Biol.

Study discovers simple rules underlying complex brain development in fly

Mon Jun 29, 2015
graphic of fly eye
Langen et al. / Cell 2015

A fruit fly’s compound eye contains 800 prism-like facets whose six distinct photoreceptor cells capture light coming in from different angles in space. These signals must all find their way to different spots in the fly brain’s visual map of the world.

How does brain circuitry organize itself during development? In at least one case—the seemingly complex visual system of the fruit fly, which connects its 800-facet compound eyes to its brain—the answer lies in just three simple rules.

StartX, QB3 partnership targets biotech startups in Palo Alto accelerator

Fri Jun 19, 2015

New Palo Alto lab for life science startups

Fri Jun 19, 2015

What are some of the leading life science incubators?

Fri Jun 19, 2015

Depression: Divide in diagnoses for women (UCSF study seeks to create better prosthetic limbs)

Fri Jun 19, 2015

Computer-designed Rocker is Protein World’s First to Biomimic Ion Transport

Fri Jun 12, 2015

Pharmacist interventions, formulary conversion tools, and warfarin discharge education take top honors at annual seminar

Wed May 20, 2015
winners

Rifkind Award winners (left to right) An-Chi Tseng, PharmD; Anh Doan, PharmD; and Lily Xia, PharmD; Clara Mikhaeil, PharmD; Heidemarie MacMaster, PharmD.

Studies of pharmacist interventions during comprehensive medication reviews, the impact of new tools to aid drug selection from a hospital formulary, and a project ensuring that hospital patients receiving anti-clotting drugs are properly educated upon discharge took top honors at the Department of...

Publications: Winter 2015

Wed Apr 1, 2015
Pharmaceutical Chemistry faculty members have published the following manuscripts since January 2015


An improved single-chain Fab platform for efficient display and recombinant expression.
Koerber JT, Hornsby MJ, Wells JA.
J Mol Biol. 2015 Jan 30;427(2):576-86.

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