UCSF

Topics and Expertise: tuberculosis

Data-driven drug dosing speeds tuberculosis treatment to four months

A large trial of a new drug regimen for tuberculosis, designed in part by School researchers, leads to a new WHO recommendation for treating the disease.

Research points to individualized treatments for curing TB

Tuberculosis is usually treated with a six month regimen of daily antibiotics, but millions of patients do not recover from the disease during treatment. Rada Savic’s team showed that adjusting the duration of this regimen based on disease severity could lead to better outcomes.

Data for a difference

Low-cost drug treatments can cure TB and malaria. Why, then, do these diseases claim so many lives?

Paul Ortiz de Montellano, PhD

Professor

My laboratory investigates the mechanisms of heme proteins, the roles they play, and approaches for their inhibition in therapeutic situations of enzymes in both humans and bacteria that have heme groups.

Rada Savic, PhD

Professor

I investigate the causes of variations in clinical outcomes, using computational methods. My goal is to determine the optimal dosage, timing, and duration of therapeutic regimens. Ultimately, I want to develop precise, personalized treatments.