Topics and Expertise: NMR spectroscopy

Helium recycling project sets a new standard for sustainability at UCSF

Thu Jun 17, 2021
Helium recycling equipment

The UCSF Schools of Pharmacy and Medicine now use helium recycling equipment, shown above, to avoid wasting the gas, which is used to cool certain types of scientific and medical imaging machines.

The School is now recycling much of the helium used in its NMR facilities.

Fragment-based discovery: using smaller molecules to solve larger challenges

Thu Mar 24, 2016
KSHV dimer
ChemMedChem, 28 JAN 2016

Protease enzymes of the Kaposi’s sarcoma-associated herpesvirus (KSHV Pr) require two monomer proteins to combine into a dimer in order to activate. Dotted black box is the protein-protein interface targeted for disruption by Craik Lab researchers. (Colored balls represent amino acids—methionines—labeled to help determine if screened fragments inhibit dimerization.)

To discover new drugs and chemical probes, researchers have traditionally screened small molecules—small enough by weight to pass through cell membranes.

John Gross, PhD

Wed Mar 13, 2013
Gross
Professor


I am interested in protein structure and dynamics related to gene expression. We study changes in protein structure that occur on time scales ranging from millions of years to a millionth of a second, with a focus on basic questions of how viruses cross-species and give rise to modern pandemics...