Shoichet research one of top breakthroughs for 2009

Wired Science has cited a computational model developed in the UCSF School of Pharmacy under the direction of faculty member Brian Shoichet, PhD, and applied and tested by scientists at the University of North Carolina at Chapel Hill School of Medicine, as one of the Top Scientific Breakthroughs for 2009. The model calculates and maps new off-target effects of drugs. While drugs are designed to be selective, some bind to several sites which, the authors point out, explains side effects and efficacy. The authors conclude that application of their method of analysis might suggest side-effects and new drug applications.

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Top Scientific Breakthroughs of 2009

Research paper

Predicting new molecular targets for known drugs, Nature, November 1, 2009

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Method to Predict Polypharmacology Developed in Shoichet Lab

About the School: The UCSF School of Pharmacy is a premier graduate-level academic organization dedicated to improving health through precise therapeutics. It succeeds through innovative research, by educating PharmD health professional and PhD science students, and by caring for the therapeutics needs of patients while exploring innovative new models of patient care. The School was founded in 1872 as the first pharmacy school in the American West. It is an integral part of UC San Francisco, a leading university dedicated to promoting health worldwide.