UCSF

Nadav Ahituv, PhD

What I do

My research focuses on understanding how nucleotide variation in gene regulatory elements can lead to human disease and other phenotypes. 

Departmental research area

My research expertise

functional genomics, gene regulation, human genetics, mouse genetic engineering, gene therapy, obesity, neurodevelopment, cancer diagnosis

Degrees

PhD, Human Genetics, Tel Aviv University, 2002
BSc, Biology, Tel Aviv University, 1996

Biography

The Ahituv lab is focused on understanding the role of regulatory sequences in human biology and disease. Through a combination of comparative genomic strategies, biochemical assays, regulatory element analysis, human patient samples, mouse and fish genetic engineering technologies, and massively parallel reporter assays they are working to elucidate mechanisms whereby genetic variation within these sequences lead to changes in human phenotypes.

Research keywords

  • enhancers
  • limb malformations
  • autism
  • pharmacogenomics
  • epilepsy
  • noncoding DNA
  • obesity
  • mouse models
  • comparative genomics
  • Human genetics
  • gene regulation
  • genomics
  • scoliosis
  • Zebrafish
  • Forelimb
  • Syndactyly
  • Exons
  • Congenital Limb Deformities
  • Regulatory Elements, Transcriptional
  • transcription factors
  • Gene Expression Regulation, Developmental
  • Thumb
  • Enhancer Elements, Genetic
  • Gene Expression Regulation
  • Promoter Regions, Genetic
  • Chiroptera
  • Regulatory Sequences, Nucleic Acid
  • Hand Deformities, Congenital
  • Sequence Analysis, DNA