My research group studies how molecular chaperones maintain protein homeostasis. This question is important because imbalances in protein homeostasis are linked to a number of incurable diseases, including neurodegenerative disorders. Molecular chaperones regulate all aspects of a protein’s...
Ken A. Dill and Hue Sun Chan, Nature Structural Biology, January 1997, Volume 4, No. 1.
Energy landscape image that represents the reduction of conformational entropy as protein chains fold to their native states
Understanding protein folding is key to understanding what goes wrong in diseases, such as Alzheimer's disease, that result when proteins misfold. UCSF School of Pharmacy faculty members Ken Dill, PhD, and Andrej Sali, PhD, comment on the history of and next steps in protein folding research.