UCSF

Tagged: protein folding

DeGrado receives Protein Society’s Stein and Moore Award

William DeGrado, PhD, faculty member in the School’s Department of Pharmaceutical Chemistry, has been named the 2015 recipient of The Protein Society’s Stein and Moore Award.

The award is given annually by the international society “to recognize eminent leaders in protein science who have made sustained high-impact research contributions to the field.”

Jason Gestwicki, PhD

Gestwicki
Professor in Residence

My research group studies how molecular chaperones maintain protein homeostasis. This question is important because imbalances in protein homeostasis are linked to a number of incurable diseases, including neurodegenerative disorders. Molecular chaperones regulate all aspects of a protein’s lifecycle, including its expression, folding, trafficking and degradation. However, it isn’t yet clear how we might promote the activity of chaperones to cure diseases. Our approach to this question is to develop chemical probes that reveal how chaperones interact with disease-associated proteins.

Predicting Protein Shape: the Next Research Challenge

Understanding protein folding is key to understanding what goes wrong in diseases, such as Alzheimer's disease, that result when proteins misfold. UCSF School of Pharmacy faculty members Ken Dill, PhD, and Andrej Sali, PhD, comment on the history of and next steps in protein folding research.