Jason Sello, PhD

Professor
Executive Committee Member
Department of Pharmaceutical Chemistry
Sello
[email protected]
Phone: +1 415 514-7368
600 16th St, Rm N572D
UCSF Box 2280
San Francisco, CA 94158
United States

Links

UCSF Profiles

Affiliations

UCSF centers, institutes, and research programs

Quantitative Biosciences Institute (QBI)
Investigator, Chan Zuckerberg Biohub
Associate Director, Office of Diversity and Outreach
Faculty Equity Advisor, School of Pharmacy

Research keywords

  • Bacterial Proteins
  • Streptomyces
  • Mycobacterium tuberculosis
  • Proteasome Inhibitors
  • Drug Resistance, Bacterial
  • Tryptophan-tRNA Ligase
  • Scandium
  • Mesylates
  • Depsipeptides
  • Gene Expression Regulation, Bacterial
  • Streptomyces coelicolor
  • Peptides, Cyclic
  • Endopeptidase Clp
  • Parabens
  • Anti-Bacterial Agents

Publications

Alabi PE, Gautier C, Murphy TP, Gu X, Lepas M, Aimanianda V, Sello JK, Ene IV. Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates. mBio. 2023 08 31; 14(4):e0047923.
Wang S, Li Z, Aispuro D, Guevara N, Van Valkenburgh J, Chen B, Zhou X, McCarroll MN, Ji F, Cong X, Sarkar P, Chaudhuri R, Guo Z, Perkins NP, Shao S, Sello JK, Chen K, Xue M. Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge. J Am Chem Soc. 2022 11 09; 144(44):20288-20297.
Schmitz KR, Handy EL, Compton CL, Gupta S, Bishai WR, Sauer RT, Sello JK. Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in Vitro. ACS Chem Biol. 2023 04 21; 18(4):724-733.
Craig E, Calarco A, Conte R, Ambrogi V, d'Ayala GG, Alabi P, Sello JK, Cerruti P, Kima PE. Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections. Front Cell Infect Microbiol. 2021; 11:702676.
Priyamvada L, Alabi P, Leon A, Kumar A, Sambhara S, Olson VA, Sello JK, Satheshkumar PS. Discovery of Retro-1 Analogs Exhibiting Enhanced Anti-vaccinia Virus Activity. Front Microbiol. 2020; 11:603.
Rosenstein JK, Rose C, Reda S, Weber PM, Kim E, Sello J, Geiser J, Kennedy E, Arcadia C, Dombroski A, Oakley K, Chen SL, Tann H, Rubenstein BM. Principles of Information Storage in Small-Molecule Mixtures. IEEE Trans Nanobioscience. 2020 07; 19(3):378-384.
Arcadia CE, Kennedy E, Geiser J, Dombroski A, Oakley K, Chen SL, Sprague L, Ozmen M, Sello J, Weber PM, Reda S, Rose C, Kim E, Rubenstein BM, Rosenstein JK. Multicomponent molecular memory. Nat Commun. 2020 02 04; 11(1):691.
Morgens DW, Chan C, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Zhou J, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, Bassik MC. Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins. Elife. 2019 11 01; 8.
Thorn RJ, Dombroski A, Eller K, Dominguez-Gonzalez TM, Clift DE, Baek P, Seto RJ, Kahn ES, Tucker SK, Colwill RM, Sello JK, Creton R. Analysis of vertebrate vision in a 384-well imaging system. Sci Rep. 2019 Sep 27; 9(1):13989.
McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D. Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation. Nat Commun. 2019 09 09; 10(1):4078.
Zhang R, Lord DM, Bajaj R, Peti W, Page R, Sello JK. A peculiar IclR family transcription factor regulates para-hydroxybenzoate catabolism in Streptomyces coelicolor. Nucleic Acids Res. 2018 02 16; 46(3):1501-1512.
Craig E, Huyghues-Despointes CE, Yu C, Handy EL, Sello JK, Kima PE. Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections. PLoS Negl Trop Dis. 2017 May; 11(5):e0005556.
Totaro KA, Barthelme D, Simpson PT, Jiang X, Lin G, Nathan CF, Sauer RT, Sello JK. Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome. ACS Infect Dis. 2017 02 10; 3(2):176-181.
Arvanitis M, Li G, Li DD, Cotnoir D, Ganley-Leal L, Carney DW, Sello JK, Mylonakis E. A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus. PLoS One. 2016; 11(4):e0153912.
Amor AJ, Schmitz KR, Sello JK, Baker TA, Sauer RT. Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle. ACS Chem Biol. 2016 06 17; 11(6):1552-1560.
Carney DW, Schmitz KR, Scruse AC, Sauer RT, Sello JK. Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase. Chembiochem. 2015 Sep 07; 16(13):1875-1879.
Totaro KA, Barthelme D, Simpson PT, Sauer RT, Sello JK. Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines. Bioorg Med Chem. 2015 Sep 15; 23(18):6218-22.
Compton CL, Fernandopulle MS, Nagari RT, Sello JK. Genetic and Proteomic Analyses of Pupylation in Streptomyces coelicolor. J Bacteriol. 2015 Sep; 197(17):2747-53.
Compton CL, Carney DW, Groomes PV, Sello JK. Fragment-Based Strategy for Investigating and Suppressing the Efflux of Bioactive Small Molecules. ACS Infect Dis. 2015 Jan 09; 1(1):53-8.
Schmitz KR, Carney DW, Sello JK, Sauer RT. Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4587-95.
Carney DW, Compton CL, Schmitz KR, Stevens JP, Sauer RT, Sello JK. A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity. Chembiochem. 2014 Oct 13; 15(15):2216-20.
Carney DW, Nelson CD, Ferris BD, Stevens JP, Lipovsky A, Kazakov T, DiMaio D, Atwood WJ, Sello JK. Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Bioorg Med Chem. 2014 Sep 01; 22(17):4836-47.
Handy EL, Totaro KA, Lin CP, Sello JK. Efficient and regiospecific syntheses of peptides with piperazic and dehydropiperazic acids via a multicomponent reaction. Org Lett. 2014 Jul 03; 16(13):3488-91.
Carney DW, Schmitz KR, Truong JV, Sauer RT, Sello JK. Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity. J Am Chem Soc. 2014 Feb 05; 136(5):1922-9.
Nelson CD, Carney DW, Derdowski A, Lipovsky A, Gee GV, O'Hara B, Williard P, DiMaio D, Sello JK, Atwood WJ. A retrograde trafficking inhibitor of ricin and Shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses. mBio. 2013 Nov 12; 4(6):e00729-13.
Compton CL, Schmitz KR, Sauer RT, Sello JK. Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase. ACS Chem Biol. 2013 Dec 20; 8(12):2669-77.
Davis JR, Goodwin L, Teshima H, Detter C, Tapia R, Han C, Huntemann M, Wei CL, Han J, Chen A, Kyrpides N, Mavrommatis K, Szeto E, Markowitz V, Ivanova N, Mikhailova N, Ovchinnikova G, Pagani I, Pati A, Woyke T, Pitluck S, Peters L, Nolan M, Land M, Sello JK. Genome Sequence of Streptomyces viridosporus Strain T7A ATCC 39115, a Lignin-Degrading Actinomycete. Genome Announc. 2013 Jul 05; 1(4).
Davis JR, Brown BL, Page R, Sello JK. Study of PcaV from Streptomyces coelicolor yields new insights into ligand-responsive MarR family transcription factors. Nucleic Acids Res. 2013 Apr 01; 41(6):3888-900.
Sello JK. Mining the antibiotic resistome. Chem Biol. 2012 Oct 26; 19(10):1220-1.
Davis JR, Goodwin LA, Woyke T, Teshima H, Bruce D, Detter C, Tapia R, Han S, Han J, Pitluck S, Nolan M, Mikhailova N, Land ML, Sello JK. Genome sequence of Amycolatopsis sp. strain ATCC 39116, a plant biomass-degrading actinomycete. J Bacteriol. 2012 May; 194(9):2396-7.
Totaro KA, Okandeji BO, Sello JK. Use of a multicomponent reaction for chemoselective derivatization of multiple classes of metabolites. Chembiochem. 2012 May 07; 13(7):987-91.
Morin JB, Adams KL, Sello JK. Replication of biosynthetic reactions enables efficient synthesis of A-factor, a γ-butyrolactone autoinducer from Streptomyces griseus. Org Biomol Chem. 2012 Feb 28; 10(8):1517-20.
Carney DW, Truong JV, Sello JK. Investigation of the configurational stabilities of chiral isocyanoacetates in multicomponent reactions. J Org Chem. 2011 Dec 16; 76(24):10279-85.
Okandeji BO, Greenwald DM, Wroten J, Sello JK. Synthesis and evaluation of inhibitors of bacterial drug efflux pumps of the major facilitator superfamily. Bioorg Med Chem. 2011 Dec 15; 19(24):7679-89.
Badu-Nkansah A, Sello JK. Deletion of the elongation factor 4 gene (lepA) in Streptomyces coelicolor enhances the production of the calcium-dependent antibiotic. FEMS Microbiol Lett. 2010 Oct; 311(2):147-51.
Socha AM, Tan NY, LaPlante KL, Sello JK. Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent. Bioorg Med Chem. 2010 Oct 15; 18(20):7193-202.
Socha AM, Sello JK. Efficient conversion of triacylglycerols and fatty acids to biodiesel in a microwave reactor using metal triflate catalysts. Org Biomol Chem. 2010 Oct 21; 8(20):4753-6.
Morin JB, Sello JK. Efficient synthesis of a peculiar vicinal diamine semiochemical from Streptomyces natalensis. Org Lett. 2010 Aug 06; 12(15):3522-4.
Vecchione JJ, Sello JK. Regulation of an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene via ribosome-mediated transcriptional attenuation. J Bacteriol. 2010 Jul; 192(14):3565-73.
Davis JR, Sello JK. Regulation of genes in Streptomyces bacteria required for catabolism of lignin-derived aromatic compounds. Appl Microbiol Biotechnol. 2010 Apr; 86(3):921-9.
Vecchione JJ, Alexander B, Sello JK. Two distinct major facilitator superfamily drug efflux pumps mediate chloramphenicol resistance in Streptomyces coelicolor. Antimicrob Agents Chemother. 2009 Nov; 53(11):4673-7.
Okandeji BO, Sello JK. Brønsted acidity of substrates influences the outcome of passerini three-component reactions. J Org Chem. 2009 Jul 17; 74(14):5067-70.
Davis JB, Bailey JD, Sello JK. Biomimetic synthesis of a new class of bacterial signaling molecules. Org Lett. 2009 Jul 16; 11(14):2984-7.
Vecchione JJ, Sello JK. A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin. Antimicrob Agents Chemother. 2009 Sep; 53(9):3972-80.
Sello JK, Buttner MJ. The oligoribonuclease gene in Streptomyces coelicolor is not transcriptionally or translationally coupled to adpA, a key bldA target. FEMS Microbiol Lett. 2008 Sep; 286(1):60-5.
Vecchione JJ, Sello JK. Characterization of an inducible, antibiotic-resistant aminoacyl-tRNA synthetase gene in Streptomyces coelicolor. J Bacteriol. 2008 Sep; 190(18):6253-7.
Okandeji BO, Gordon JR, Sello JK. Catalysis of Ugi four component coupling reactions by rare earth metal triflates. J Org Chem. 2008 Jul 18; 73(14):5595-7.
Sello JK, Buttner MJ. The gene encoding RNase III in Streptomyces coelicolor is transcribed during exponential phase and is required for antibiotic production and for proper sporulation. J Bacteriol. 2008 Jun; 190(11):4079-83.
Pacholec M, Sello JK, Walsh CT, Thomas MG. Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol. Org Biomol Chem. 2007 Jun 07; 5(11):1692-4.
Sello JK, Andreana PR, Lee D, Schreiber SL. Stereochemical control of skeletal diversity. Org Lett. 2003 Oct 30; 5(22):4125-7.
Lee D, Sello JK, Schreiber SL. Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis. Org Lett. 2000 Mar 09; 2(5):709-12.
Quadri LE, Sello J, Keating TA, Weinreb PH, Walsh CT. Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin. Chem Biol. 1998 Nov; 5(11):631-45.