Topics and Expertise: cancer

Manglik, Arkin, Bastian receive Mark Foundation ASPIRE Award for moonshot cancer research

Thu Feb 23, 2023
Manglik, Arkin, Bastian.
Elisabeth Fall

Left to right: Aashish Manglik, MD, PhD; Michelle Arkin, PhD; and Boris Bastian, MD, PhD.

Funding from the Mark Foundation for Cancer Research will fuel high-risk, high-impact research on uveal melanoma.

How one private biotech seized on JPM to emerge from stealth and tell its story

Wed Jan 25, 2023

Map of protein systems reveals new targets for cancer treatment

Thu Dec 9, 2021
A branching network of protein systems
Krogan Lab

A birds-eye depiction of the findings from the Quantitative Biosciences Institute’s recent work on cancer. Each node represents a protein system and darker-colored nodes are more likely to be involved in cancer.

Scientists at the UCSF Quantitative Biosciences institute developed a new approach for understanding cancer and applied it to breast cancer and cancers of the neck and head

Synthetic biomaterial guides cancer therapy to hidden tumors

Wed Jan 20, 2021
DNA double helix

Tejal Desai, PhD, and colleagues took inspiration from the structure of DNA to engineer a biomaterial that promises to improve CAR-T cell therapy for various cancers.

Advance opens up new possibilities for CAR T-cell therapy to treat a variety of cancers

Unmasking a cellular hallmark of cancer

Mon Jan 29, 2018
Wells
Elisabeth Fall

James Wells, PhD, lead author on paper

Scientists identify a signature of cancers caused by mutant RAS that may lead to precise therapies.

Guo applies curiosity and collaboration to research

Thu Sep 14, 2017
Guo
© majedphoto.com

Su Guo, PhD

“There are lots of important problems. Only attack those for which you can divine simple experiments with clear answers.”—Julius Axelrod

Renslo Lab develops new type of targeted chemotherapy that proves effective in mice

Mon Dec 12, 2016
Renslo
Elisabeth Fall

Adam Renslo, PhD

Research in the lab of UCSF School of Pharmacy faculty member Adam Renslo, PhD, has developed a new way of selectively targeting cancer cells with drugs. In experiments with mice, the new approach allowed for the delivery of fifty times higher doses of chemotherapy to tumors while avoiding toxic...

UCSF School of Pharmacy leads in NIH funding for 36th year in a row

Thu Mar 31, 2016
NIH rank graphic
UCSF News
For the 36th consecutive year, the UCSF School of Pharmacy has received more funding from the National Institutes of Health (NIH) than any other pharmacy school in the United States.

Fragment-based discovery: using smaller molecules to solve larger challenges

Thu Mar 24, 2016
KSHV dimer
ChemMedChem, 28 JAN 2016

Protease enzymes of the Kaposi’s sarcoma-associated herpesvirus (KSHV Pr) require two monomer proteins to combine into a dimer in order to activate. Dotted black box is the protein-protein interface targeted for disruption by Craik Lab researchers. (Colored balls represent amino acids—methionines—labeled to help determine if screened fragments inhibit dimerization.)

To discover new drugs and chemical probes, researchers have traditionally screened small molecules—small enough by weight to pass through cell membranes.

Abate honored by White House with Presidential Early Career Award

Fri Feb 19, 2016
Abate

Adam Abate, PhD

UCSF School of Pharmacy faculty member Adam Abate, PhD, has been named a recipient of the Presidential Early Career Award for Scientists and Engineers, the highest honor bestowed by the U.S. government on science and engineering professionals in the early stages of their independent research...

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