Nancy Sambol, PharmD

Associate Professor

Department of Bioengineering and Therapeutic Sciences

Elisabeth Fall

[email protected]

Phone: +1 415 476-8884

Fax: +1 415 502-4322

513 Parnassus Ave, MSB, Rm 1124A

UCSF Box 0912

San Francisco, CA 94117

United States

Links

Division of Clinical Pharmacology & Experimental Therapeutics

UCSF Profiles

Educational programs

PharmD Degree Program

What I do

I focus on the use of models to describe drug disposition and effect in patient populations, and the use of these models to make predictions to improve drug therapy.

Departmental research area

drug development and regulatory sciences

My research expertise

modeling and simulation of pharmacokinetics/pharmacodynamics, information-driven trial design, censored data, extravascular drug modeling, pediatrics, anesthesiology, antimalarials, cardiovascular

Degrees

BSc, Pharmacy, University of Illinois at Chicago, 1987

PharmD, Pharmacy, University of Texas at Austin, 1983

BSc, Pharmacy, Purdue University, 1978

Research keywords

Obesity, Morbid, Antithrombin III, Gastric Bypass, Fibrinolytic Agents, Quinolines, Antimalarials, Malaria, Falciparum, Levonorgestrel, Enoxaparin, Metformin, Hypoglycemic Agents, chemoprevention, Contraceptives, Oral, Synthetic, malaria, Artemisinins

Licensure and certifications

Licentiate in Pharmacy, California, 1985

Publications

Hoglund RM, Workman L, Edstein MD, Thanh NX, Quang NN, Zongo I, Ouedraogo JB, Borrmann S, Mwai L, Nsanzabana C, Price RN, Dahal P, Sambol NC, Parikh S, Nosten F, Ashley EA, Phyo AP, Lwin KM, McGready R, Day NP, Guerin PJ, White NJ, Barnes KI, Tarning J. Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis. PLoS Med. 2017 01; 14(1):e1002212.

Tchaparian E, Sambol NC, Arinaitwe E, McCormack SA, Bigira V, Wanzira H, Muhindo M, Creek DJ, Sukumar N, Blessborn D, Tappero JW, Kakuru A, Bergqvist Y, Aweeka FT, Parikh S. Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria. J Infect Dis. 2016 Oct 15; 214(8):1243-51.

Sambol NC, Tappero JW, Arinaitwe E, Parikh S. Rethinking Dosing Regimen Selection of Piperaquine for Malaria Chemoprevention: A Simulation Study. PLoS One. 2016; 11(5):e0154623.

Sambol NC, Yan L, Creek DJ, McCormack SA, Arinaitwe E, Bigira V, Wanzira H, Kakuru A, Tappero JW, Lindegardh N, Tarning J, Nosten F, Aweeka FT, Parikh S. Population Pharmacokinetics of Piperaquine in Young Ugandan Children Treated With Dihydroartemisinin-Piperaquine for Uncomplicated Malaria. Clin Pharmacol Ther. 2015 Jul; 98(1):87-95.

Dempsey DA, Sambol NC, Jacob P, Hoffmann E, Tyndale RF, Fuentes-Afflick E, Benowitz NL. CYP2A6 genotype but not age determines cotinine half-life in infants and children. Clin Pharmacol Ther. 2013 Sep; 94(3):400-6.

Borkgren-Okonek MJ, Hart RW, Pantano JE, Rantis PC, Guske PJ, Kane JM, Gordon N, Sambol NC. Enoxaparin thromboprophylaxis in gastric bypass patients: extended duration, dose stratification, and antifactor Xa activity. Surg Obes Relat Dis. 2008 Sep-Oct; 4(5):625-31.

Sambol NC, Harper CC, Kim L, Liu CY, Darney P, Raine TR. Pharmacokinetics of single-dose levonorgestrel in adolescents. Contraception. 2006 Aug; 74(2):104-9.

Tibbitts J, Sambol NC, Fike JR, Bauer WF, Kahl SB. Plasma pharmacokinetics and tissue biodistribution of boron following administration of a boronated porphyrin in dogs. J Pharm Sci. 2000 Apr; 89(4):469-77.

Liu CY, Sambol NC. Pharmacodynamic analysis of analgesic clinical trials: nonlinear mixed-effects logistic models. J Biopharm Stat. 1999 May; 9(2):253-70.

Sambol NC, Chiang J, O'Conner M, Liu CY, Lin ET, Goodman AM, Benet LZ, Karam JH. Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus. J Clin Pharmacol. 1996 Nov; 36(11):1012-21.

Sambol NC, Brookes LG, Chiang J, Goodman AM, Lin ET, Liu CY, Benet LZ. Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man. Br J Clin Pharmacol. 1996 Oct; 42(4):510-2.

Liu FY, Sambol NC, Giannini RP, Liu CY. In vitro-in vivo relationship of oral extended-release dosage forms. Pharm Res. 1996 Oct; 13(10):1501-6.

Sambol NC, Chiang J, Lin ET, Goodman AM, Liu CY, Benet LZ, Cogan MG. Kidney function and age are both predictors of pharmacokinetics of metformin. J Clin Pharmacol. 1995 Nov; 35(11):1094-102.

Wade JR, Sambol NC. Felodipine population dose-response and concentration-response relationships in patients with essential hypertension. Clin Pharmacol Ther. 1995 May; 57(5):569-81.

Liu FY, Sambol NC, Giannini RP, Liu CY. Pharmacokinetics of oral extended-release dosage forms. I. Release kinetics, concentration, and absorbed fraction. Pharm Res. 1995 May; 12(5):720-8.

Liu CY, Sambol NC. Pharmacodynamic analysis of analgesic clinical trials using empirical methods. Pharm Res. 1995 Mar; 12(3):438-45.

Wade JR, Beal SL, Sambol NC. Interaction between structural, statistical, and covariate models in population pharmacokinetic analysis. J Pharmacokinet Biopharm. 1994 Apr; 22(2):165-77.

Kochak GM, Berner B, Leal M, Sambol NC. Variational analysis of the transdermal delivery rate from two prototypical ethanol-water nitroglycerin TTS devices and Transderm-Nitro 10 in the normal population. J Pharmacokinet Biopharm. 1992 Oct; 20(5):443-59.

Sambol NC, Sheiner LB. Population dose versus response of betaxolol and atenolol: a comparison of potency and variability. Clin Pharmacol Ther. 1991 Jan; 49(1):24-31.

Sambol NC, Bostrom A, Williams RL. Effect of hydrochlorothiazide 25 mg/day on essential hypertension. Clin Pharm. 1990 Nov; 9(11):873-5.

Cook E, Clifton GG, Vargas R, Bienvenu G, Williams R, Sambol N, McMahon G, Grandy S, Lai CM, Quon C. Pharmacokinetics, pharmacodynamics, and minimum effective clinical dose of intravenous nicardipine. Clin Pharmacol Ther. 1990 Jun; 47(6):706-18.

Sheiner LB, Beal SL, Sambol NC. Study designs for dose-ranging. Clin Pharmacol Ther. 1989 Jul; 46(1):63-77.

Sambol NC, Upton RA, Chremos AN, Lin ET, Williams RL. A comparison of the influence of famotidine and cimetidine on phenytoin elimination and hepatic blood flow. Br J Clin Pharmacol. 1989 Jan; 27(1):83-7.

Benz C, DeGregorio M, Saks S, Sambol N, Holleran W, Ignoffo R, Lewis B, Cadman E. Sequential infusions of methotrexate and 5-fluorouracil in advanced cancer: pharmacology, toxicity, and response. Cancer Res. 1985 Jul; 45(7):3354-8.