Leslie Carstensen Floren, PharmD, PhD, MA

Associate Dean of Fellow­ships
Department of Clinical Pharmacy
[email protected]
Phone: +1 415 514-3559
513 Parnassus Avenue, MSB, Rm 951
UCSF Box 0150
San Francisco, CA 94143
United States

Links

Division of Clinical Pharmacology & Experimental Therapeutics UCSF Profiles

Affiliations

Joint appointments

Associate Professor, Department of Clinical Pharmacy

UCSF centers, institutes, and research programs

UCSF Helen Diller Family Comprehensive Cancer Center
Codirector, Clinical Pharmacology and Therapeutics (CPT) Postdoctoral Training Program

What I do

As associate dean of fellowships, I am responsible for coordination of fellowship programs within the School of Pharmacy. The primary duties include: serving as a resource for PharmD students regarding available academic and industry postdoctoral fellowships; serving as primary liaison with the UCSF Industry Contracts Division; coordinating recruitment, placement, onboarding, and mentoring activities for fellows across UCSF’s fellowship programs.

I co-direct the UCSF Clinical Pharmacology and Therapeutics Fellowship Program as well as the UCSF-Genentech Clinical Development Fellowship, where I am responsible for leading didactic education focused on clinical pharmacology and provide mentorship around career development.

I am also an adjunct associate clinical professor in the Department of Clinical Pharmacy and a licensed pharmacist, practicing and precepting learners in UCSF’s interprofessional Care Transitions Outreach Program. My research efforts have been focused on investigating the role of knowledge construction and learning through interprofessional interaction in the context of clinical education.

My research expertise

drug development

Professional background

Degrees

PhD, Health Professions Education, University of Utrecht, Netherlands, 2022
MA, Education (Health Professions Focus), University of California, Berkeley, 2014
PharmD, University of California, San Francisco, 1994
BA, Biochemistry/Cell Biology, University of California, San Diego, 1989

Biography

Leslie Carstensen Floren, PharmD, DABCP is an Associate Adjunct Professor of Bioengineering and Therapeutic Sciences (BTS) in the School of Pharmacy at UCSF, the Academic Coordinator and Director of Professional and Postdoctoral Educational Affairs in BTS as well as the co-Director of the NIH-funded, UCSF Clinical Pharmacology Fellowship Training Program. Her teaching responsibilities for the past several years have included, primarily, teaching pharmacokinetics/pharmacodynamics, clinical pharmacology and principles of drug development and regulatory sciences to a wide variety of students, including professional students in the PharmD program, Clinical Pharmacology Fellows, junior faculty members, and working professionals from industrial backgrounds. Teaching is one of her greatest pleasures and she has been honored to receive the School of Pharmacy Dean’s Recognition for Excellence in Teaching every year since 2005 and, in 2010, she received the highest honor in the School of Pharmacy for teaching, the Long Award for Excellence in Teaching. Dr. Floren has a keen interest in curriculum development, teaching methodology and assessment, educational technology and online education and will begin training in the School of Medicine 2012-2013 Teaching Scholars Program in order to develop innovative curricula, to implement novel teaching methods and to use technology in order to “bring to life” the principles of Pharmacokinetics, Pharmacodynamics and Clinical Pharmacology for a wide variety of students within and across disciplines and, ultimately, to have a positive impact on patient health. She also plans to conduct scholarly research that will demonstrate the utility of practice-based teaching methods in order to advance interdisciplinary pharmaceutical sciences education within UCSF, our local community and across the country.

Research keywords

  • Interprofessional Relations
  • Health Education
  • Professional Role
  • Students, Health Occupations
  • Patient Care Team
  • Pharmacology, Clinical
  • Learning
  • Education, Distance
  • Health Occupations
  • Students, Medical
  • Education, Professional
  • Cooperative Behavior
  • Health Personnel
  • Students, Pharmacy
  • Education, Pharmacy

Publications

Floren LC, Pittenger AL, Wilting I, Irby DM, Cate OT. Medical Residents' Informal Learning from Pharmacists in the Clinical Workplace. Med Sci Educ. 2023 May 06; 1-10.
Byerly LK, Floren LC, Yukawa M. Fostering Interprofessional Geriatric Patient Care Skills for Health Professions Students Through a Nursing Facility-Based Immersion Rotation. MedEdPORTAL. 2020 12 24; 16:11059.
Bautista CA, Huang I, Stebbins M, Floren LC, Wamsley M, Youmans SL, Hsia SL. Development of an interprofessional rotation for pharmacy and medical students to perform telehealth outreach to vulnerable patients in the COVID-19 pandemic. J Interprof Care. 2020 Sep-Oct; 34(5):694-697.
Floren LC, Ten Cate O, Irby DM, O'Brien BC. An interaction analysis model to study knowledge construction in interprofessional education: proof of concept. J Interprof Care. 2021 Sep-Oct; 35(5):736-743.
Byerly LK, Floren LC, Yukawa M, O'Brien BC. Getting outside the box: exploring role fluidity in interprofessional student groups through the lens of activity theory. Adv Health Sci Educ Theory Pract. 2021 03; 26(1):253-275.
Floren LC, Mandal J, Dall'Era M, Shin J, Irby DM, Cate OT, O'Brien BC. A Mobile Learning Module to Support Interprofessional Knowledge Construction in the Health Professions. Am J Pharm Educ. 2020 02; 84(2):847519.
Brouwer KLR, Schmidt S, Floren LC, Johnson JA. Clinical Pharmacology Education - The Decade Ahead. Clin Pharmacol Ther. 2020 01; 107(1):37-39.
Oosterom N, Floren LC, Ten Cate O, Westerveld HE. A review of interprofessional training wards: Enhancing student learning and patient outcomes. Med Teach. 2019 05; 41(5):547-554.
Floren LC, Donesky D, Whitaker E, Irby DM, Ten Cate O, O'Brien BC. Are We on the Same Page? Shared Mental Models to Support Clinical Teamwork Among Health Professions Learners: A Scoping Review. Acad Med. 2018 03; 93(3):498-509.
Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51.
Daud AI, Xu C, Hwu WJ, Urbas P, Andrews S, Papadopoulos NE, Floren LC, Yver A, Deconti RC, Sondak VK. . Cancer Chemother Pharmacol. Pharmacokinetic/pharmacodynamic analysis of adjuvant pegylated interferon alpha-2b in patients with resected high-risk melanoma. 2011; (67):657-66.
DeConti RC, Algazi AP, Andrews S, Urbas P, Born O, Stoeckigt D, Floren L, Hwang J, Weber J, Sondak VK, Daud AI. . Br J Cancer. Phase II trial of sagopilone, a novel epothilone analog in metastatic melanoma. 2010; (10):1548-53.
GR Tonn, SG Wong, SC Wong, MG Johnson, J Ma, R Cho, LC Floren, K Kersey, K Berry, AP Marcus, X Wang, B Van Lengerich, JC Medina, PG Pearson, and BK Wong. . Drug Metab Dispos. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing. 2009; (37):502-13.
A. P. Venook, E. K. Rowinsky, R. C. Donehower, T. Leung, L. C. Floren, M. Levy. Safety and pharmacokinetics (PK) of T138067 (T67) administered as a weekly 3-hour infusion in subjects with hepatocellular carcinoma (HCC) in a phase 1 study. Journal of Clinical Oncology. 2004 Jul 15; 22(14_suppl):4087-4087.
A. P. Venook, E. K. Rowinsky, R. C. Donehower, T. Leung, L. C. Floren, M. Levy. Safety and pharmacokinetics (PK) of T138067 (T67) administered as a weekly 3-hour infusion in subjects with hepatocellular carcinoma (HCC) in a phase 1 study. Journal of Clinical Oncology. 2004 Jul 15; 22(14_suppl):4087-4087.
LA Frassetto, Thai T, Aggarwal A, Bucher P, Jacobsen W, U Christians, LZ Benet, LC Floren. . Drug Metab Pharmacokinet. Pharmacokinetic Interactions between Cyclosporine and Protease Inhibitors in HIV+ Subjects. 2003; (18):114-20.
LC Floren, A Wiznia , SA Hayashi, A Jaywardene, K Stanley, G Johnson, S Nachman, P Krosstad, F Aweeka. . Pediatrics. Nelfinavir pharmacokinetics in stable HIV-positive children: AIDS Clinical Trials Group Protocol 377. 2003; 3(112):e220-27.
L Mancinelli, L Frassetto, LC Floren, D Dressler, S Carrier, I Bekersky, LZ Benet, U Christians. . Clin Pharmacol Ther. The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. 2001; (69):24-31.
L.C. Floren, U. Christians, J.J. Zimmerman, L. Neefe, R. Schorer, D. Rushworth, D. Harper, J. Renz, L.Z. Benet. Sirolimus oral bioavailability increases ten-fold with concomitant ketoconazole. Clinical Pharmacology & Therapeutics. 1999 Feb 1; 65(2):159-159.
LC Floren, MF Hebert, AP Venook, VC Jordan, A Cisneros, and KA Somberg. . Ann Onc. Tamoxifen in liver disease: potential exacerbation of hepatic function. 1998; (9):1123-26.
C Cheng and LC Floren. . CJHP. Pharmacogenetics: The clinical significance of cytochrome P450 polymorphisms. 1998; (10):11-4.
U Christians, W Jacobsen and LC Floren. . Pharmacol Ther. Metabolism and drug interactions of the 3-hydroxy-3methylglutaryl Coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?. 1998; (80):1-34.
LC Floren, I Bekersky, LZ Benet, QA Mekki, DE Dressler, JW Lee, JP Roberts, and MF Hebert. . Clin Pharmacol Ther. Tacrolimus oral bioavailability doubles with co-administration of ketoconazole. 1997; (62):41-9.
U Christians, LC Floren, G Kirchner, and K-F Sewing. . Transplantationsmedizen. The clinical pharmacokinetics of macrolide immunosuppressants and its impact on the clinical management of organ transplantation. 1997; (9):S2-S6.
L. Floren, J.G. Gambertoglio, S. Martin-Munley, F. Aweeka. Foscarnet Pharmacokinetics (PK) During Continuous Ambulatory Peritoneal Dialysis (CAPD). Clinical Pharmacology & Therapeutics. 1996 Feb 1; 59(2):142-142.