UCSF

Tagged: ZINC

Creating an inexhaustible database for drug molecules

School of Pharmacy researchers helped a free public database of potential drug molecules grow 100-fold.

Shoichet receives DeLano Award for Computational Biosciences

Brian Shoichet, PhD, faculty member in the School’s Department of Pharmaceutical Chemistry, has been named the 2017 recipient of the DeLano Award for Computational Biosciences.

Fragment-based discovery: using smaller molecules to solve larger challenges

To discover new drugs and chemical probes, researchers have traditionally screened small molecules—small enough by weight to pass through cell membranes.

Shoichet study sheds light on “dark” cell receptors, potential drug targets

More than a quarter of all drugs work by targeting one of a large family of proteins called G-protein-coupled receptors (GPCRs). Hundreds of different GPCRs are embedded in cell membranes, converting stimuli from the outside world—neurotransmitters, hormones, even light—into intracellular signals...