Bani Tamraz, PharmD, PhD

Associate Professor

Department of Clinical Pharmacy

Elisabeth Fall

[email protected]

Phone: +1 415 476-8013

521 Parnassus Avenue, Rm 3606

UCSF Box 0622

San Francisco, CA 94117

United States

Links

UCSF Profiles

Affiliations

What I do

My primary interest is identification of genetic determinants of drug response through modern methods aimed at addressing pharmacogenomics research and translating that information into new diagnostics and treatment strategies at point-of-care.

Departmental research area

clinical research

My research expertise

pharmacogenetics, clinical pharmacogenetics

Professional background

Degrees

PhD, Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, 2011

PharmD, University of California, San Francisco, 2003

BS, Chemistry, University of California, Davis, 1999

Licensure and certifications

Licentiate in Pharmacy, California State Board of Pharmacy, 2004

Biography

My primary interest is identification of genetic determinants of drug response and translating that information into practical treatment strategies: Discovery to application. The MACS/WIHS Combined Cohort Study (MWCCS), formerly The Women’s Interagency HIV Study (WIHS) cohort, a multi-center longitudinal observational cohort, currently provides the perfect laboratory for conducting pharmacogenomics (PGx) research. I have nested several PGx studies within WIHS, providing me with the opportunity to examine how PGx factors interact with other pharmacokinetic factors to determine drug exposure and treatment outcome. In particular, my work with WIHS has enabled me to examine PGx variations associated with ethnicity which is an understudied, but high priority area of research. Besides PGx studies in HIV, I have studies in the areas of pediatric bone marrow transplant, ophthalmology and in vitro fertilization.

In addition to discovery work, I am leading projects with an overarching vision of creating the UCSF Health-School of Pharmacy service for translating known PGx findings into clinical practice. At present, I am completing CLIA-certification of a gene panel that can provide PGx guidance for the use of 42 medications in UCSF Health. Following CLIA validation, the clinical application will be launched first with lung transplant service to pre-emptively genotype patients wait listed for transplant and use PGx to guide tacrolimus dosing post- transplant. I am leading several spin off projects related to clinical application of PGx at UCSF: a cost-effectiveness analysis of PGx in transplant and development of clinical decision support (CDS) structure for delivering the PGx-based treatment recommendations to clinicians.

In summary, I have numerous active research projects, various collaborations and a growing clinical project that I am certain will produce meaningful results.

Research keywords

pharmacogenetics
membrane transporters
Metabolomics
Epigenomics
drug interactions
clinical pharmacogenetics
Electronic Clinical Decision Support
pharmacogenomics
Mobile Health
Cost Effectiveness Analysis
HIV Protease Inhibitors
Mortality
Pharmacogenomic Variants
Pharmacogenomic Testing
Rhabdomyolysis
Atazanavir Sulfate
Long QT Syndrome
Receptors, Cell Surface
Organic Anion Transporters
HIV Infections
Drug Monitoring
Hair
Central Nervous System Depressants
Methadone
pharmacogenetics

1.	February Featured Investigator, Pharmacogenomics Research Network, 2019
2.	Twice recipient of Dean’s Apple Award in recognition of outstanding teaching spring/summer, UCSF School of Pharmacy, 2019
3.	The Amgen Research Excellence in Biopharmaceutical Sciences Fellow, Amgen, 2010-2011
4.	CHIH Foundation Fellowship Award, CHIH Foundation, 2008
5.	Graduate Dean's Health Science Fellowship, University of California, San Francisco, 2006-2007
6.	American Foundation for Pharmaceutical Education (AFPE) Gateway Research Scholarship, American Association of Pharmaceutical Scientists, 2002-2003
7.	Dow Chemical Company Chemistry Scholarship, University of California, Davis, 1998

Publications

McCrimmon T, Collins LF, Pereyra M, Platamone C, Perez-Brumer A, Shaffer VA, Kerrigan D, Sheth AN, Cohen MH, Hanna DB, Ramirez C, Gange SJ, Rana A, Tamraz B, Goparaju L, Wilson TE, Alcaide M, Philbin MM. Likelihood of Trying Long-Acting Injectable Antiretroviral Therapy Among Women With HIV in Nine Sites Across the United States. J Acquir Immune Defic Syndr. 2024 07 01; 96(3):e23-e27.

Tamraz B, Venook AP. DPYD Pharmacogenetics: To Opt-in or to Opt-out. JCO Oncol Pract. 2024 Aug; 20(8):1009-1011.

A B U B A K E R SAEED, Musie Ghebremichael, Deborah Konkle-Parker, Deborah Jones Weiss, Shelby Collins, Adaora A Adimora, Michael F Schneider, Mardge H Cohen, Bani Tamraz, Michael Plankey, Tracey Wilson, Adebola adedimeji, Jessica Haberer, Denise L Jacobson Jacobson. 1606. Dual Trajectories of Antiretroviral Therapy Adherence and Polypharmacy in Women with HIV in the United Sate. Open Forum Infectious Diseases. 2023 Nov 27; 10(Supplement_2):ofad500.1441.

Kaing A, Adeleye A, Tamraz B, Fujimoto VY. Exploratory cohort study into underlying mechanism of differences in estrogen metabolism between Asian and Caucasian women during assisted reproductive technology treatment. F S Rep. 2023 Dec; 4(4):396-401.

KEVIN YEN, SHYLAJA SRINIVASAN, LAURA A. DAPKUS, BANI TAMRAZ, UMESH MASHARANI, SHANNON E. MCCABE, LISA KROON. 862-P: Reduced Metformin Clearance Is Associated with Increased Metformin-Related Side Effects in Older Adults with Type 2 Diabetes (T2D). Diabetes. 2023 Jun 20; 72(Supplement_1).

Elbur AI, Ghebremichael M, Konkle-Parker D, Jones DL, Collins S, Adimora AA, Schneider MF, Cohen MH, Tamraz B, Plankey M, Wilson T, Adedimeji A, Haberer JE, Jacobson DL. Dual trajectories of antiretroviral therapy adherence and polypharmacy in women with HIV in the United States. AIDS Res Ther. 2023 05 13; 20(1):29.

Elbur AI, Ghebremichael M, Konkle-Parker D, Jones DL, Collins S, Adimora AA, Schneider MF, Cohen MH, Tamraz B, Plankey M, Wilson T, Adedimeji A, Haberer J, Jacobson DL. Trajectories of Antiretroviral Therapy Adherence and Virologic Failure in Women With HIV in the United States. J Acquir Immune Defic Syndr. 2023 06 01; 93(2):162-170.

Elbur AI, Ghebremichael M, Konkle-Parker D, Jones DL, Collins S, Adimora AA, Schneider MF, Cohen MH, Tamraz B, Plankey M, Wilson T, Adedimeji A, Haberer JE, Jacobson DL. Dual Trajectories of Antiretroviral Therapy Adherence and Polypharmacy in Women with HIV in the United States. Res Sq. 2023 Jan 23.

Philbin MM, McCrimmon T, Shaffer VA, Kerrigan D, Pereyra M, Cohen MH, Sosanya O, Sheth AN, Adimora AA, Topper EF, Rana A, Tamraz B, Goparaju L, Wilson TE, Alcaide M. A Patient Decision Aid (i.ARTs) to Facilitate Women's Choice Between Oral and Long-Acting Injectable Antiretroviral Treatment for HIV: Protocols for its Development and Randomized Controlled Pilot Trial. JMIR Res Protoc. 2022 Sep 13; 11(9):e35646.

Psomas CK, Hoover DR, Shi Q, Brown TT, Vance DE, Holman S, Plankey MW, Tien PC, Weber KM, Floris-Moore M, Bolivar HH, Golub ET, McDonnell Holstad M, Radtke KK, Tamraz B, Erlandson KM, Rubin LH, Sharma A. Polypharmacy Is Associated With Falls in Women With and Without HIV. J Acquir Immune Defic Syndr. 2022 07 01; 90(3):351-359.

Rubin LH, Neijna AG, Shi Q, Hoover DR, Tamraz B, Anastos K, Edmonds A, Fischl MA, Gustafson D, Maki PM, Merenstein D, Sheth AN, Springer G, Vance D, Weber KM, Sharma A. Degree of Polypharmacy and Cognitive Function in Older Women with HIV. AIDS Res Hum Retroviruses. 2022 07; 38(7):571-579.

Matthew Ryan, Karla Lindquist, Anica Wandler, Cynthia Morgan, Sawona Biswas, Elena Flowers, Patrick Devine, Teresa Sparks, Maren Scheuner, Bani Tamraz, Thomas Hoffmann, Joseph Shieh, Neil Risch, Katherine Hyland. eP467 Are clinicians ready for genomic medicine?: assessing educational needs. Molecular Genetics and Metabolism. 2021 Apr 1; 132:s299.

Patasova K, Khawaja AP, Tamraz B, Williams KM, Mahroo OA, Freidin M, Solebo AL, Vehof J, Falchi M, Rahi JS, Hammond CJ, Hysi PG. Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort. Invest Ophthalmol Vis Sci. 2021 02 01; 62(2):15.

Ramsey LB, Ong HH, Schildcrout JS, Shi Y, Tang LA, Hicks JK, El Rouby N, Cavallari LH, Tuteja S, Aquilante CL, Beitelshees AL, Lemkin DL, Blake KV, Williams H, Cimino JJ, Davis BH, Limdi NA, Empey PE, Horvat CM, Kao DP, Lipori GP, Rosenman MB, Skaar TC, Teal E, Winterstein AG, Owusu Obeng A, Salyakina D, Gupta A, Gruber J, McCafferty-Fernandez J, Bishop JR, Rivers Z, Benner A, Tamraz B, Long-Boyle J, Peterson JF, Van Driest SL, IGNITE Pharmacogenetics Working Group. Prescribing Prevalence of Medications With Potential Genotype-Guided Dosing in Pediatric Patients. JAMA Netw Open. 2020 12 01; 3(12):e2029411.

Leddy AM, Sheira LA, Tamraz B, Sykes C, Kashuba ADM, Wilson TE, Adedimeji A, Merenstein D, Cohen MH, Wentz EL, Adimora AA, Ofotokun I, Metsch LR, Turan JM, Bacchetti P, Weiser SD. Food Insecurity Is Associated With Lower Levels of Antiretroviral Drug Concentrations in Hair Among a Cohort of Women Living With Human Immunodeficiency Virus in the United States. Clin Infect Dis. 2020 09 12; 71(6):1517-1523.

Dumond JB, Bay CP, Nelson JAE, Davalos A, Edmonds A, De Paris K, Sykes C, Anastos K, Sharma R, Kassaye S, Tamraz B, French AL, Gange S, Ofotokun I, Fischl MA, Vance DE, Adimora AA. Intracellular Tenofovir and Emtricitabine Concentrations in Younger and Older Women with HIV Receiving Tenofovir Disoproxil Fumarate/Emtricitabine. Antimicrob Agents Chemother. 2020 08 20; 64(9).

Ionova Y, Ashenhurst J, Zhan J, Nhan H, Kosinski C, Tamraz B, Chubb A. CYP2C19 Allele Frequencies in Over 2.2 Million Direct-to-Consumer Genetics Research Participants and the Potential Implication for Prescriptions in a Large Health System. Clin Transl Sci. 2020 11; 13(6):1298-1306.

Patel RC, Stalter RM, Thomas KK, Tamraz B, Blue SW, Erikson DW, Kim CJ, Kelly EJ, Nanda K, Kourtis AP, Lingappa JR, Mugo N, Baeten JM, Scarsi KK, Partners PrEP Study Team. A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda. AIDS. 2019 11 01; 33(13):1995-2004.

Tamraz B, Huang Y, French AL, Kassaye S, Anastos K, Nowicki MJ, Gange S, Gustafson DR, Bacchetti P, Greenblatt RM, Hysi PG, Aouizerat BE, Women's Interagency HIV Study. Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV-Infected Women. Clin Pharmacol Ther. 2020 02; 107(2):315-318.

Tamraz B, Reisner L, French AL, King ST, Fischl MA, Ofotokun I, Kashuba A, Milam J, Murphy K, Augenbraun M, Liu C, Finley PR, Aouizerat B, Cocohoba J, Gange S, Bacchetti P, Greenblatt RM. Association between Use of Methadone, Other Central Nervous System Depressants, and QTc Interval-Prolonging Medications and Risk of Mortality in a Large Cohort of Women Living with or at Risk for Human Immunodeficiency Virus Infection. Pharmacotherapy. 2019 09; 39(9):899-911.

Zakinova, Angela, Long-Boyle, Janel R., French, Deborah, Croci, Rhiannon, Wilson, Leslie, Phillips, Kathryn A., Kroetz, Deanna L., Shin, Jaekyu., Tamraz, Bani.. A practical first step using needs assessment and a survey approach to implementing a clinical pharmacogenomics consult service. Journal of American College of Clinical Pharmacy. 2019; 2(3):214-221.

Zakinova A, Long-Boyle JR, French D, Croci R, Wilson L, Phillips KA, Kroetz DL, Shin J, Tamraz B. A Practical First Step Using Needs Assessment and a Survey Approach to Implementing a Clinical Pharmacogenomics Consult Service. J Am Coll Clin Pharm. 2019 Jun; 2(3):214-221.

Hysi PG, Khawaja AP, Menni C, Tamraz B, Wareham N, Khaw KT, Foster PJ, Benet LZ, Spector TD, Hammond CJ. Ascorbic acid metabolites are involved in intraocular pressure control in the general population. Redox Biol. 2019 01; 20:349-353.

Sykes C, Blake K, White N, Schauer AP, Guzman BB, Cottrell ML, Tamraz B, Kashuba ADM. Development and validation of an LC-MS/MS assay for the quantification of dolutegravir extracted from human hair. Anal Bioanal Chem. 2018 Nov; 410(29):7773-7781.

Rubin LH, Radtke KK, Eum S, Tamraz B, Kumanan KN, Springer G, Maki PM, Anastos K, Merenstein D, Karim R, Weber KM, Gustafson D, Greenblatt RM, Bishop JR. Cognitive Burden of Common Non-antiretroviral Medications in HIV-Infected Women. J Acquir Immune Defic Syndr. 2018 09 01; 79(1):83-91.

Tamraz B, Huang Y, French AL, Kassaye S, Anastos K, Nowicki MJ, Gange S, Gustafson DR, Bacchetti P, Greenblatt RM, Hysi PG, Aouizerat BE. A Genome-Wide Association Study Identifies a Candidate Gene Associated With Atazanavir Exposure Measured in Hair. Clin Pharmacol Ther. 2018 11; 104(5):949-956.

Pearce CL, Stram D, Wiensch A, Frasco MA, Kono N, Den Berg DV, Anastos K, Cohen MH, DeHovitz J, Golub ET, Tamraz B, Liu C, Mack WJ. Pharmacogenetic Associations with ADME Variants and Virologic Response to an Initial HAART Regimen in HIV-Infected Women. Int J HIV AIDS Res. 2017; 4(3):154-160.

Tamraz B, Fukushima H, Wolfe AR, Kaspera R, Totah RA, Floyd JS, Ma B, Chu C, Marciante KD, Heckbert SR, Psaty BM, Kroetz DL, Kwok PY. OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis. Pharmacogenet Genomics. 2013 Jul; 23(7):355-64.

Floyd JS, Kaspera R, Marciante KD, Weiss NS, Heckbert SR, Lumley T, Wiggins KL, Tamraz B, Kwok PY, Totah RA, Psaty BM. A screening study of drug-drug interactions in cerivastatin users: an adverse effect of clopidogrel. Clin Pharmacol Ther. 2012 May; 91(5):896-904.

Marciante KD, Durda JP, Heckbert SR, Lumley T, Rice K, McKnight B, Totah RA, Tamraz B, Kroetz DL, Fukushima H, Kaspera R, Bis JC, Glazer NL, Li G, Austin TR, Taylor KD, Rotter JI, Jaquish CE, Kwok PY, Tracy RP, Psaty BM. Cerivastatin, genetic variants, and the risk of rhabdomyolysis. Pharmacogenet Genomics. 2011 May; 21(5):280-8.

Kaspera R, Naraharisetti SB, Tamraz B, Sahele T, Cheesman MJ, Kwok PY, Marciante K, Heckbert SR, Psaty BM, Totah RA. Cerivastatin in vitro metabolism by CYP2C8 variants found in patients experiencing rhabdomyolysis. Pharmacogenet Genomics. 2010 Oct; 20(10):619-29.

Trivedi NN, Tamraz B, Chu C, Kwok PY, Caughey GH. Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. J Allergy Clin Immunol. 2009 Nov; 124(5):1099-105.e1-4.

N. Trivedi, B. Tamraz, P.Y. Kwok, G.H. Caughey. An Inactivating, Frame-shifted Mutation of ,III Tryptase is Common in People of Northern and Western European Ancestory. Journal of Allergy and Clinical Immunology. 2009 Mar 1; 123(3):728-729.

Reich D, Patterson N, Ramesh V, De Jager PL, McDonald GJ, Tandon A, Choy E, Hu D, Tamraz B, Pawlikowska L, Wassel-Fyr C, Huntsman S, Waliszewska A, Rossin E, Li R, Garcia M, Reiner A, Ferrell R, Cummings S, Kwok PY, Harris T, Zmuda JM, Ziv E, Health, Aging and Body Composition (Health ABC) Study. Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet. 2007 Apr; 80(4):716-26.