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Michael Keiser, PhD
Asst Professor in Residence
Institute for Neurodegenerative Diseases
What I do
Our group investigates how drugs affect entire networks of proteins in the body at once to achieve their therapeutic effects, via computational predictions paired with experimental testing.
Departmental research area
My research expertise
Systems pharmacology, Machine learning, Forward polypharmacology, Computational chemical biology, Neurodegeneration, Adverse drug reactions, Network structure, Chemical-genetic epistasis
PhD, Bioinformatics, University of California, San Francisco, 2009
Bachelors in Arts and Sciences, Slavic language and Literature/Computer Science, Stanford University, 2004
Masters, Russian and Eurasian Studies, Stanford University, 2004
Our lab investigates how small molecules perturb protein target networks to biological and therapeutic effect. In a forward polypharmacology campaign, we are using machine learning and computational methods such as the Similarity Ensemble Approach (SEA) to infer new combinations of targets underlying compound-induced phenotypes in cells and broader model systems. Thinking of each target as a musical note, we predict and test entire chords at a time via chemical-genetic epistasis experiments in models of complex diseases such as neurodegeneration.
These systems pharmacology inquiries tell us where current understanding of drug action is weak, and because we use human pharmacology to mine for mechanisms, we can apply the therapeutic chords we find directly to the prediction of patient drug responses, adverse drug reactions, and personalized medicine.