UCSF

Tagged: transcription factors

Giacomini to lead largest study of genetic, ethnic differences in effectiveness of leading diabetes drug

In people with type 2 diabetes, the body is less able to use the hormone insulin to regulate blood sugar. The disease affects 350 million patients globally—including 29 million in the United States, where it is the leading cause of blindness, kidney failure, and non-accident-related amputations.

Nadav Ahituv study provides new insights into enhancer gene regulation

Research led by UCSF scientists has provided fresh insight into the operation of DNA sequences in the genome that regulate gene expression.

The new study looked at the effects of inserting nearly 5,000 synthetic regulatory element sequences into mice as well as human liver cells. Specifically, these were enhancers, snippets of DNA which, when bound by protein molecules called transcription factors, contribute to gene activation.