UCSF

Tagged: Drug Discovery

Training computers to think more like scientists

Fri Apr 19, 2019
Dogs and wolves comparison

Machine learning algorithms can be trained to distinguish wolves from dogs in photographs, but sometimes these algorithms learn incorrectly by assuming that any animal pictured with snow in the background is a wolf (bottom right). Two School scientists argue that scientific applications of machine learning also need to be monitored to ensure they are working properly.

Michael Keiser, PhD, and Kangway Chuang, PhD, want to use machine learning to speed the pace of drug discovery. By digging into the work of another lab, the pair realized how machine learning could lead scientists astray—and came up with methods to avoid its worst pitfalls.

School of Pharmacy scientists unearth a new target for treating Parkinson’s disease

Thu Mar 7, 2019
Neuronal protein with newly-identified drug target highlighted
Credit: 
England Lab/UCSF

A team led by Pamela England, PhD, identified a new target (yellow) for future Parkinson’s disease therapies within the Nurr1 protein (blue). 

Scientists in the UCSF School of Pharmacy recently identified the first drug-binding target site on a molecule known to play a role in Parkinson's disease, opening the door to a new generation of therapies for the condition.

Creating an inexhaustible database for drug molecules

Mon Feb 11, 2019
Shoichet in his office
Credit: 
Elisabeth Fall

Brian Shoichet, PhD, brought his drug discovery software to an enormous database of small molecules.

School of Pharmacy researchers helped a free public database of potential drug molecules grow 100-fold.

Fraser appointed to Bowes Biomedical Investigator Program

Wed Jan 9, 2019
Fraser stands in front of a whiteboard
Credit: 
Elisabeth Fall

James Fraser, PhD, developed new ways of doing crystallography over a wide range of temperatures.

Fraser developed several new tools for creating maps of macromolecules, a critical first step for finding new drugs.

Keiser receives $2.5 million to apply machine learning towards new therapies for Alzheimer’s, Parkinson’s

Tue Jan 8, 2019
Keiser
Credit: 
UCSF

Michael Keiser, PhD, received a Ben Barres Early Career Acceleration Award from the Chan Zuckerberg Initiative, which will support his research into novel therapies for neuro­de­gener­a­tion.

Michael Keiser, PhD, received a Ben Barres Early Career Acceleration Award from the Chan Zuckerberg Initiative, which will fund his research into novel therapies for neurodegeneration.

School of Pharmacy emeriti Kollman, Kuntz, and Langridge honored with UCSF Medal

Thu Nov 15, 2018
composite of Langridge, Kollman, Kuntz, and a wasabi receptor computer graphic
Drug discovery today begins with computation rather than test tube experimentation. Three School of Pharmacy faculty emeriti, Robert Langridge, Irwin “Tack” Kuntz, and the late Peter Kollman, were awarded the UCSF Medal for creating computational tools for drug discovery that are now used worldwide.

Showcasing School science and change at Alumni Weekend 2018

Fri Jun 15, 2018
Guglielmo speaks at podium.
Credit: 
Levi Gadye

B. Joseph Guglielmo, PharmD, addressed Half Century Club Luncheon attendees.

For UCSF School of Pharmacy alumni who attended the event, Alumni Weekend 2018 offered a chance to explore how science connects the School’s research, education, and patient care agendas; learn about the lives and professional accomplishments of pharmacy school graduates; and get a glimpse of what’s under way at UCSF beyond the School. The annual campuswide event was held at the Hyatt Regency San Francisco on June 1 and 2.

Seiple named a 2018 Beckman Young Investigator

Tue Jun 12, 2018
Seiple

Ian Seiple, PhD

The Beckman Young Investigator award provides research support to the most promising young faculty members in the early stages of their academic careers in the chemical and life sciences.

Prien and MacWilliam bequests establish new endowed professorships

Wed Dec 7, 2016
Prien, MacWilliam
Credit: 
Foresight, newsletter of UCSF Office of Gift & Endowment Planning

Ernest Prien, BS ’34 and Mary MacWilliam, EdD, UC Berkeley, 1956

The UCSF School of Pharmacy has established new endowed faculty positions to be held by the chairs of two School departments.

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