UCSF

Tagged: Ligands

Computer models speed UCSF scientists toward psychiatric drug discoveries

For decades, scientists have wanted to be able to study dopamine receptors one by one. The brain’s dopamine receptors are responsible for a variety of behaviors, such as reward seeking, and are also involved in psychiatric illnesses like schizophrenia.

Michael Keiser, PhD

Assistant Professor

Our group investigates how drugs affect entire networks of proteins in the body at once to achieve their therapeutic effects, via computational predictions paired with experimental testing.

Brian Shoichet, PhD

Professor

Our lab develops new methods for drug discovery, adopting two strategies to do so. On the one hand, we reduce biology to its molecular components, and seek to change how these fit together using synthetic molecules we design. On the other hand, we investigate how the biological molecules operate...

Tack Kuntz, PhD

Professor Emeritus

Since retiring, I serve as a consultant for current Department faculty.