UCSF

Tagged: brain

Shoichet study sheds light on “dark” cell receptors, potential drug targets

More than a quarter of all drugs work by targeting one of a large family of proteins called G-protein-coupled receptors (GPCRs). Hundreds of different GPCRs are embedded in cell membranes, converting stimuli from the outside world—neurotransmitters, hormones, even light—into intracellular signals that can change cell behavior.

Use of Amyloid Inhibitors Cautioned

Brian Shoichet, PhD, School of Pharmacy faculty member and Brian Feng, PhD, former staff research associate with the School, and colleagues have discovered that many amyloid inhibitors, which scientists had hoped would keep "sticky" amyloid protein fibers such as those associated with Alzheimer's disease from aggregating in brain tissue, actually clump together themselves.