A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes: a QBI Hybrid Seminar with Catera Wilder

The QBI Seminar Series presents Catera Wilder, assistant professor in the Department of Bioengineering and Therapeutic Sciences at the University of California San Francisco and Chan Zuckerberg Biohub Investigator. She received her Ph.D. in biomedical engineering (2016) under the direction of Manu Platt. As a UCLA Chancellor’s Postdoctoral Fellow in the lab of Alexander Hoffmann (2016-2022) she focused on understanding innate immune and inflammatory responses by studying ISGF3 transcription factor dynamic regulation using a systems biology approach. Her work investigating the interferon signaling and transcriptional regulation has uncovered stimulus specific responses determined by coordinated stimulus-contingent positive feedback loops. She is interested in investigating the spatiotemporal control of intra- and inter-cellular IFN signaling networks and developing predictive, quantitative tools of immune responses.

Talk Title: A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes

Host: James Fraser