NSF and NIH Recognize Kortemme's Leadership in AI-Driven Protein Design

Department of Bioengineering and Therapeutic Sciences professor and Vice Dean of Research Tanja Kortemme, PhD, is pushing the boundaries of protein engineering with research that uses artificial intelligence to design shapeshifting proteins — dynamic molecules that mimic the complex movements of natural proteins.  

Published in Science, her lab’s latest study reveals an essential characteristic for regulating biological processes such as metabolism and cell signaling, which could enable new classes of therapeutics, biosensors, and environmentally sustainable materials. 

Kortemme’s lab continues to attract support for its innovative approach. She recently received a $1.4 million award from the National Science Foundation as part of a $7.2 million collaborative investment across four institutions and a company, focused on using deep learning to engineer programmable, sustainable biosynthesis. The team’s target: a fully recyclable, heat-resistant bioplastic. 

Adding to Kortemme’s momentum, her application and interview for the NIH Pioneer Award application — a prestigious and highly competitive grant — placed her proposal among the top 8 percent. While final funding decisions are pending, the recognition reflects strong enthusiasm for her vision of integrating AI and molecular design to advance health and sustainability.

Read the full story on her latest work

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• Kortemme named new vice dean of research 

• Kortemme awarded International Feodor Lynen Medal from the German Society for Biochemistry and Molecular Biology 

• How proteins orchestrate the biology of the cell 

• How cells multitask: the magic of molecular switches