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QBI Bay Area Chemical Biology Symposium
QBI presents the inaugural QBI Bay Area Symposium on Chemical Biology on September 26–27, 2022, organized by Drs. Jim Wells, Kevan Shokat, Jason Gestwicki, Chris Chang, and Carolyn Bertozzi. Under the leadership of Dr. Nevan Krogan, the Quantitative Biosciences Institute (QBI) seeks transformative results in biomedicine by supporting fundamental quantitative research in the biological sciences.
In support of this mission, the meeting will focus on the latest cutting-edge chemical biology research to address unmet biological problems with new technologies and targets from top scientists in the Bay Area.
The meeting will provide opportunities for scientists at all career stages, including faculty, undergrad, graduate and postdoc levels to present their research in dynamic talks, Twitter interviews, panel discussions, poster sessions, and mixers.
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Confirmed speakers
Who | Organization |
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Patrick Baeuerle | MPM Capital |
Matt Bogyo | Stanford University |
Paul Carter | Genentech |
Jamie Cate | University of California, Berkeley |
Andrew Chan | Genentech |
Chris Chang | University of California, Berkeley |
Michelle Chang | University of California, Berkeley |
James Chen | Stanford University |
Charly Craik | University of California, San Francisco |
Laura Dassama | Stanford University |
Ray Deshaies | Amgen |
Bill DeGrado | University of California, Berkeley |
Jennifer Doudna | University of California, Berkeley |
Pam England | University of California, San Francisco |
Polly Fordyce | Stanford University |
Matt Francis | University of California, Berkeley |
Danica Fujimori | University of California, San Francisco |
Zev Gartner | University of California, San Francisco |
Jason Gestwicki | University of California, San Francisco |
Charles Homcy | BridgeBio |
Nathanael Gray | Stanford University |
Natalia Jura | University of California, San Francisco |
Peter Kim | Stanford University |
Eric Kool | Stanford University |
Misty Kuhn | San Francisco State University |
Lingyin Li | Stanford University |
Shiva Malek | Novartis |
John Link | Gilead Sciences |
Michael Marletta | University of California, Berkeley |
Nicole Martinez | Stanford University |
Evan Miller | University of California, Berkeley |
Dan Nomura | University of California, Berkeley |
Adam Renslo | University of California, San Francisco |
Alanna Schepartz | University of California, Berkeley |
Ian Seiple | University of California, San Francisco |
Jason Sello | University of California, San Francisco |
Kevan Shokat | University of California, San Francisco |
Xiaokun Shu | University of California, San Francisco |
Jack Taunton | University of California, San Francisco |
Alice Ting | Stanford University |
Lei Wang | University of California, San Francisco |
Jim Wells | University of California, San Francisco |
Allison Williams | University of California, San Francisco |
Balyn Zaro | University of California, San Francisco |
Wenjun Zhang | University of California, Berkeley |
Agenda
Session | Time | Name | Chair |
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Day 1: Monday, September 26 |
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1 | 9:10 – 10:25 a.m. | Chemical Biology of Metals | Nathanael Gray |
2 | 10:45 a.m. – 12:00 noon | Chemoproteomics and Covalent Therapeutics | Danica Fujimori |
3 | 1:15 – 2:20 p.m. | Engineered Sensors for Proteins, Cells and Animals | Michael Marletta |
4 | 2:45 – 4:00 p.m. | Protein and Tissue Engineering | Alanna Schepartz |
4:00 - 5:00 p.m. | Closing Remarks | ||
5:00 - 6:00 p.m. | Poster Session | ||
6:00 - 7:00 p.m. | Reception | ||
Day 2: Tuesday, September 27 |
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5 | 9:10 – 10:25 a.m. | Natural and Synthetic Small Molecules in Drug Discovery and Therapy | Peter Kim |
6 | 10:40 – 11:45 a.m. | Chemical Microbiology and Immunology | Bill DeGrado |
7 | 1:45 – 2:50 p.m. | Intracellular Signaling | Chris Chang |
4:00 – 7:00 p.m. | Closing & Reception |
Day 1: Monday, September 26
8:00 a.m. | Registration and Breakfast |
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9:00 – 9:10 a.m. | Symposium begins: Welcome from organizers |
Session 1: 9:10 – 10:25 a.m.: Chemical Biology of Metals · Chair: Nathanael Gray
9:10 a.m. | Chris Chang · Transition Metal Signaling and Metalloallostery: Bioinorganic Chemistry Beyond Active Site |
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9:20 a.m. | Michelle Chang · Synthetic biology approaches to new chemistry |
9:30 a.m. | Adam Renslo · Chemical tools to study labile iron in cells and animals |
9:40 a.m. | Laura Dassama · Chemical biology tools for hematologic disorders |
9:50 a.m. | Michael Marletta · Probing for novel therapeutic targets in human and plant disease |
10:00 a.m. | Jim Wells · Proximity labeling for high resolution protein neighborhoods |
10:10 a.m. | Questions (15 minutes) |
10:25 – 10:45 a.m. | Break: coffee, tea, cookies |
Session 2: 10:45 a.m. – 12:00 noon: Chemoproteomics and Covalent Therapeutics · Chair: Danica Fujimori
10:45 a.m. | Dan Nomura · Reimagining Druggability using Chemoproteomic Platforms |
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10:55 a.m. | Nathanael Gray · Extending the Reach of Kinase Inhibitor therapy using new targeting Strategies |
11:05 a.m. | Jack Taunton · Trapped on the ribosome |
11:15 a.m. | Lei Wang · New covalent bonding ability for proteins |
11:25 a.m. | Charles Craik · Targeting an intracellular oncogene with immunotherapy against a haptenanted neoepitope |
11:35 a.m. | Kevan Shokat · Expansion of Covalent Chemistry to Target the Undruggable Oncogenic Mutants of K-RAS |
11:45 a.m. | Questions (15 minutes) |
12:00 noon – 1:15 p.m. | Lunch |
Session 3: 1:15 – 2:20 p.m.: Engineered Sensors for Proteins, Cells and Animals · Chair: Michael Marletta
1:15 p.m. | Alanna Schepartz · Protein delivery |
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1:25 p.m. | Evan Miller · Fiat Lux: Fluorescent indicators to watch cellular physiology |
1:35 p.m. | Xiaokun Shu · Functions of protein phase separation in chromatin structure and transcription |
1:45 p.m. | Polly Fordyce · Microfluidics for high-throughput biochemistry and biophysics |
1:55 p.m. | Matt Bogyo · Mapping proteases in the gut microbiome with small molecule probes |
2:05 p.m. | Questions (15 minutes) |
2:20 – 2:45 p.m. | Coffee break |
Session 4: 2:45 – 4:00 p.m.: Protein and Tissue Engineering · Chair: Alanna Schepartz
2:45 p.m. | Paul Carter · Probing the Molecular Basis of High Viscosity of Monospecific and Bispecific IgG Antibodies (tentative title) | |
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2:55 p.m. | Matt Francis · Synthesis of Protein-Protein Conjugates Using Enzymatic Oxidative Coupling Reactions | |
3:05 p.m. | Zev Gartner · What is tissue structure good for? | |
3:15 p.m. | Bill Degrado · De Novo Protein Design | |
3:25 p.m. | Alice Ting · TBD | |
3:35 p.m. | Peter Kim · Broad-spectrum protection and treatment of SARS-CoV-2 | |
3:45 p.m. | Questions (15 minutes) | |
4:00 – 4:45 p.m. |
Industry Leaders (New Visions and Challenges for Pharma) Moderator: Jim Wells; Panelists: Andrew Chan, Ray Deshaies, Shiva Malek |
|
Closing & Reception |
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4:45 – 5:00 p.m. | Closing remarks | |
5:00 – 6:00 p.m. | Poster Session | |
6:00 – 7:00 p.m. | Reception |
Day 2: Tuesday, September 27
8:00 a.m. | Registration and Breakfast |
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9:00 – 9:10 a.m. | Symposium begins: Welcome speech by organizers |
Session 5: 9:10 – 10:25 a.m.: Natural and Synthetic Small Molecules in Drug Discovery and Therapy · Chair: Peter Kim
9:10 a.m. | James Chen · Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1 |
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9:20 a.m. | Jason Sello · Illuminating Biology with Bioactive Small Molecules |
9:30 a.m. | Wenjun Zhang · Bioactive natural product discovery and biosynthesis |
9:40 a.m. | Ian Seiple · Chemical synthesis to unlock natural product potential |
9:50 a.m. | Pam England · Developing Nurr1 Modulators for Treating Neurodegneration |
10:00 a.m. | John Link · Lenacapavir: A Twice-Yearly Dosed First-in-Class HIV Capsid Inhibitor |
10:10 a.m. | Questions (15 minutes) |
10:25 – 10:40 a.m. | Break |
Session 6: 10:40 – 11:45 a.m.: Chemical Microbiology and Immunology · Chair: Bill DeGrado
10:40 a.m. | Jaime Cate · Translating T cell biology |
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10:50 a.m. | Balyn Zaro · Bacterial Mimicry of Mammalian “Don‘t Eat Me” Signals |
11:00 a.m. | Allison Williams · Decoding bacterial host communication |
11:10 a.m. | Misty Kuhn · Unraveling polyamine acetyltransferase allosteric networks |
11:20 a.m. | Lingyin Li · Chemical biology of the innate immune STING pathway |
11:30 a.m. | Questions (15 minutes) |
11:45 – 1:30 p.m. | Lunch |
1:30 – 1:45 p.m. |
Twitter Interview: Gene Editing Host: Jason Gestwicki; Guest: Jennifer Doudna |
Session 7: 1:45 – 2:50 p.m.: Intracellular Signaling · Chair: Chris Chang
1:45 p.m. | Eric Kool · RNA acylation as a universal tool for transcriptome studies |
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1:55 p.m. | Nicole Martinez · Uncovering new functions of the RNA modifications in mRNA processing |
2:05 p.m. | Danica Fujimori · Proximity Reactive Cyclic Peptides as Covalent Probes for Epigenetic Proteins |
2:15 p.m. | Natalia Jura · Mechanistic insights into signaling by protein kinases |
2:25 p.m. | Jason Gestwicki · Protein-Protein Interactions at C-Termini Regulate Protein Stability |
2:35 p.m. | Questions (15 minutes) |
2:50 – 4:00 p.m. | Poster Session with refreshments |
4:00 – 4:45 p.m. |
Entrepreneur Panel (Translating Commercial Reality) Moderator: Kevan Shokat; Panelists: Charles Homcy, Patrick Baeuerle |
Closing & Reception
4:45 – 5:00 p.m. | Closing remarks, Top 3 Posters Announced |
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5:00 – 7:00 p.m. | Final Reception and Celebration |