New review finds drug, device study results affected by funding source
An updated and expanded review of clinical research papers on drugs and medical devices finds that industry-sponsored studies are more likely to lead to favorable results, including reports of greater benefits and fewer harmful side effects.
The analysis of 48 published studies, covering conditions ranging from heart disease to psychiatric illnesses, also found that industry-funded papers were more likely to report conclusions that were inconsistent with their own results sections.
The article, “Industry sponsorship and research outcome,” is co-authored by Lisa Bero, PhD, a faculty member in the UCSF School of Pharmacy’s Department of Clinical Pharmacy. It was published in the December 12, 2012 issue of the Cochrane Database of Systematic Reviews. Bero co-directs the UCSF-based San Francisco branch of the U.S. Cochrane Center.
As a follow-up to a 2003 analysis also co-authored by Bero, the new paper looked at more than double the number of studies, used more stringent methodology, and added medical device studies.
The School of Pharmacy at UC San Francisco (UCSF) is a prominent academic institution, founded in 1872, that today pioneers the health sciences graduate-level education, biomedical research, and patient care needed to further the development and best use of precise therapeutics—medications, medical devices, and diagnostic tests—to improve the health of people everywhere. The School is an integral part of UCSF, the nation’s leading university exclusively focused on health.