Danica Galonić Fujimori, PhD, delivers the 2017 Byers Award Lecture in Basic Science. Her topic was the problem of antibiotic resistance and how research may help keep drugs effective.
Since Alexander Fleming discovered penicillin in 1940, countless lives have been saved by antibiotics. But their effectiveness is severely compromised by the emergence of antibiotic resistant strains of bacteria, accelerated by the over-prescription of antibiotics and their widespread use as growth promoters in livestock farming.
Sepsis occurs when the body responds to an infection with a mix of tissue-damaging inflammation and anti-inflammatory responses. This biological storm can lead to acute organ dysfunction (severe sepsis) and dropping blood pressure that does not respond to intravenous fluids (septic shock).
Images of P. aeruginosa biofilm—a bacterial community that takes the form of mushroom-like structures. Main/upper left image looks down at the biofilm, the lower/righthand images show cross-sections. This biofilm was cultured from the airways of a patient with cystic fibrosis.
Nearly every human bacterial infection—including some of the most serious, life threatening, and costly to treat—can take the form of a biofilm, in which bacteria aggregate into structured communities that enclose themselves within a secreted slime.
Rifkind Award Winners (clockwise from upper left) Tien Ho, PharmD; Bao Dao, PharmD, MBA; Robin Corelli, PharmD; Alicia Harvey, PharmD.
Studies of improved over-the-counter acetaminophen warning labels, more accurate measurements of antibiotics in hospitalized patients, therapies for metastatic breast cancer, and methods for training pharmacy personnel to help smokers quit took top honors at the Department of Clinical Pharmacy’s 16th Annual Spring Research Seminar.
Faculty members in the Department of Bioengineering and Therapeutic Sciences, UCSF Schools of Pharmacy and Medicine, share their research on the human microbiome and microfabricated drug delivery systems and their hopes for how their science will improve the health of patients.
Michael Fischbach, PhD, is the recipient of a 2010 NIH Director's New Innovator Award from the National Institutes of Health. Fischbach is a faculty member in the Department of Bioengineering and Therapeutic Sciences, UCSF Schools of Pharmacy and Medicine.