Xin Chen, PhD

Prof in Res-HCOMP

Department of Bioengineering and Therapeutic Sciences

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[email protected]

Phone: +1 415 502-6526

513 Parnassus Avenue, Rm 816B

UCSF Box 0912

San Francisco, CA 94117

United States

Links

Xin Chen Lab

UCSF Profiles

Affiliations

Educational programs

Pharmaceutical Sciences and Pharmacogenomics Graduate Program (PSPG)

What I do

I study molecular genetics and signaling pathways in liver cancer development with the goal to develop better targeted therapy for this deadly malignancy.

Departmental research area

Pharmacogenomics and genomics

My research expertise

Liver cancer, Gastric cancer, Colon cancer, Genomics, Signaling pathway, Stem cells, Cancer metabolism, Pharmacogenomics, Targeted therapy

Degrees

PhD, Cell and Developmental Biology, Harvard University, 1997

Bachelor of Medicine, Medicine, Beijing Medical University, Bejing, China, 1992

Biography

My lab studies molecular genetics and signaling pathways during hepatic carcinogenesis. Specifically, using genomic approaches including expression arrays and array based CGH, we have identified large numbers of genes which are deregulated during liver cancer development. Using murine models, we are studying how these genetic alterations contribute to malignant transformation and progression in vivo. Our current studies focus on AKT/mTOR and Notch pathways and how they regulate cancer metabolism and cancer cell proliferation. In addition, using the novel mouse models as preclinical models, we are testing the therapeutic potentials of PI3K/mTOR or Notch inhibitors in treating liver cancers.

Research keywords

Transfection, Liver Neoplasms, Hydrodynamics, Stomach Neoplasms, Hepatocellular Carcinoma

1.	Postdoctoral Fellowship Award, Life Science Research Foundation, Baltimore, MD, 1998
2.	First Prize Award, Beijing Medical University, Beijing, China, 1991

Publications

Chen X, Calvisi DF. Hydrodynamic transfection for generation of novel mouse models for liver cancer research. Am J Pathol. 2014 Apr; 184(4):912-23.

Cheung ST, Wong SY, Leung KL, Chen X, So S, Ng IO, Fan ST. Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma. Clin Cancer Res. 2004 Nov 15; 10(22):7629-36.

Chen X, Higgins J, Cheung ST, Li R, Mason V, Montgomery K, Fan ST, van de Rijn M, So S. Novel endothelial cell markers in hepatocellular carcinoma. Mod Pathol. 2004 Oct; 17(10):1198-210.

Leung SY, Yuen ST, Chu KM, Mathy JA, Li R, Chan AS, Law S, Wong J, Chen X, So S. Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer. Gastroenterology. 2004 Aug; 127(2):457-69.

West RB, Corless CL, Chen X, Rubin BP, Subramanian S, Montgomery K, Zhu S, Ball CA, Nielsen TO, Patel R, Goldblum JR, Brown PO, Heinrich MC, van de Rijn M. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol. 2004 Jul; 165(1):107-13.

Cui K, Tailor P, Liu H, Chen X, Ozato K, Zhao K. The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming. Mol Cell Biol. 2004 May; 24(10):4476-86.

Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13350-5.

Chen X, Leung SY, Yuen ST, Chu KM, Ji J, Li R, Chan AS, Law S, Troyanskaya OG, Wong J, So S, Botstein D, Brown PO. Variation in gene expression patterns in human gastric cancers. Mol Biol Cell. 2003 Aug; 14(8):3208-15.

Chua MS, Barry C, Chen X, Salvatierra O, Sarwal MM. Molecular profiling of anemia in acute renal allograft rejection using DNA microarrays. Am J Transplant. 2003 Jan; 3(1):17-22.

Leung SY, Chen X, Chu KM, Yuen ST, Mathy J, Ji J, Chan AS, Li R, Law S, Troyanskaya OG, Tu IP, Wong J, So S, Botstein D, Brown PO. Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16203-8.

Xu RH, Chen X, Li DS, Li R, Addicks GC, Glennon C, Zwaka TP, Thomson JA. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol. 2002 Dec; 20(12):1261-4.

Ji J, Chen X, Leung SY, Chi JT, Chu KM, Yuen ST, Li R, Chan AS, Li J, Dunphy N, So S. Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines. Oncogene. 2002 Sep 19; 21(42):6549-56.

Liu H, Kang H, Liu R, Chen X, Zhao K. Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex. Mol Cell Biol. 2002 Sep; 22(18):6471-9.

Cheung ST, Chen X, Guan XY, Wong SY, Tai LS, Ng IO, So S, Fan ST. Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor. Cancer Res. 2002 Aug 15; 62(16):4711-21.

Chen X, Cheung ST, So S, Fan ST, Barry C, Higgins J, Lai KM, Ji J, Dudoit S, Ng IO, Van De Rijn M, Botstein D, Brown PO. Gene expression patterns in human liver cancers. Mol Biol Cell. 2002 Jun; 13(6):1929-39.

Liu R, Liu H, Chen X, Kirby M, Brown PO, Zhao K. Regulation of CSF1 promoter by the SWI/SNF-like BAF complex. Cell. 2001 Aug 10; 106(3):309-18.

Sarwal M, Chang S, Barry C, Chen X, Alizadeh A, Salvatierra O, Brown P. Genomic analysis of renal allograft dysfunction using cDNA microarrays. Transplant Proc. 2001 Feb-Mar; 33(1-2):297-8.

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