Xin Chen, PhD

Phone: +1 415 502-6526
513 Parnassus Ave, MSB, Rm HSE 1421
UCSF Box 0912
San Francisco, CA 94117
United States

What I do

I study molecular genetics and signaling pathways in liver cancer development with the goal to develop better targeted therapy for this deadly malignancy.

Departmental research area

My research expertise

liver cancer, gastric cancer, colon cancer, genomics, signaling pathway, stem cells, cancer metabolism, pharmacogenomics, targeted therapy


PhD, Cell and Developmental Biology, Harvard University, 1997
Bachelor of Medicine, Medicine, Beijing Medical University, Bejing, China, 1992


My lab studies molecular genetics and signaling pathways during hepatic carcinogenesis. Specifically, using genomic approaches including expression arrays and array based CGH, we have identified large numbers of genes which are deregulated during liver cancer development. Using murine models, we are studying how these genetic alterations contribute to malignant transformation and progression in vivo. Our current studies focus on AKT/mTOR and Notch pathways and how they regulate cancer metabolism and cancer cell proliferation. In addition, using the novel mouse models as preclinical models, we are testing the therapeutic potentials of PI3K/mTOR or Notch inhibitors in treating liver cancers.