UCSF

Tagged: protease

Research: Elusive drug targets; cell demolition enzymes; useful pharmacogenomics info

Predicting difficult-to-detect drug binding sites

Fragment-based discovery: using smaller molecules to solve larger challenges

To discover new drugs and chemical probes, researchers have traditionally screened small molecules—small enough by weight to pass through cell membranes. Their goal is typically to find compounds that selectively bind to a much larger protein molecule (often an enzyme) at a chemically reactive pocket known as the active site, inhibiting its activity to treat a disease or to better understand a biological process.

Craik receives Protein Society’s Emil Thomas Kaiser Award

Charles S. Craik, PhD, faculty member in the School’s Department of Pharmaceutical Chemistry, has been named the 2016 recipient of the Protein Society’s Emil Thomas Kaiser Award.