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School of Pharmacy

UCSF School of Pharmacy

Update from the Dean

Spring/Summer 2006

Dear UCSF School of Pharmacy Family and Friends:

The summer is winding down, yet the pace here at the School never seems to slow markedly, regardless of the season. We have a lot going on, and I have a lot to report to you.

PhD Programs

I will be devoting more space to our PhD graduate programs in future Updates as issues are emerging that I feel all members of the School's family need to know well. The issues revolve around funding limitations that could hamper the viability of our graduate programs and our ability to compete into the future on the same par with our well-funded private school counterparts. As a reminder, early this decade the School reformulated its single graduate program in pharmaceutical chemistry into two multi-departmental graduate programs—one in chemistry and chemical biology (CCB) and one in pharmaceutical sciences and pharmacogenomics (PSPG). We also are heavily involved in the graduate programs in biological and medical informatics (BMI), which we revitalized; biophysics; and bioengineering, among others.

Like science graduate programs across the United States, we must fund the education of our PhD students to ensure a steady stream of talent into important health sciences research fields that are not high paying. About 30% of graduate student fees campuswide are funded from principal investigator grant monies, 31% from internal and external fellowships, 20% from federal training grants; and the rest from gifts as well as School and campus funds. As grant and fellowship monies tighten, we must look for other funding sources to support graduate education.

I will discuss this more in future letters, but I wanted to put this concern on your radar now. I look for possible solutions everywhere, one important reason being the tremendous impact of our PhD graduates. Take Victoria Hale, PhD, as an example. She received her doctorate here in pharmaceutical chemistry in Les Benet's laboratory. Now, she is the founder and CEO of the Institute for OneWorld Health, the first United States non-profit drug company, which is focused on finding affordable drugs to fight neglected diseases. Five years after Vicki began OneWorld Health, it is on the verge of getting approval from India for a drug to treat black fever, the second largest parasitic killer after malaria. Other drugs will surely follow. Michael Marletta, PhD, who received his doctorate in pharmaceutical chemistry under research advisor George Kenyon, was elected this spring to the National Academy of Sciences (NAS). As many of you know, election to the NAS is one of the highest honors in American science. Mike's research has always been at the intersection of biology and chemistry. He was a pioneer in discovering the role of nitric oxide, a critical player in communication between cells. Mike became chair of the department of chemistry at UC Berkeley in 2005.

Alumni Support

Thank you sincerely to our PhD and PharmD alumni for all of your contributions this past fiscal year in support of the School's many and various needs. I allocated US$120,000 of your total gifts in direct support to students—US$40,000 to PhD students and US$80,000 in direct support to PharmD students. Your generosity is a clear signal that alumni care.

Meeting with PharmD Alumni in Industry

We held a good and productive meeting this past May with PharmD alumni who now work in industry. Bruce Kreter '85 (Bristol-Myers Squibb) wrote to me some time ago about the idea of a meeting to explore how we might marry the interests of our students and faculty members with those of our alumni working in drug development. Mike Dudley '80 (Mpex Pharmaceuticals), Mark Shaefer '85 (GlaxoSmithKline), and Steve Barriere '73 (Theravance) endorsed the idea, and the result was an insightful day with Bruce, Mike, Mark, John Flaherty (former resident and former faculty, now at Gilead Sciences), Grace Fong '81 (Aventis), James Nickas '80 (Genentech), Stephen Rossi '90 (Roche Laboratories), Robert Stagg (former resident, now at PDL BioPharma, Inc.), Brad Stolshek '86 (Amgen), and Ray Townsend '77 (Elan Pharmaceuticals). Steve Barriere, Rebecca Coleman (former faculty, now at Theravance), Denise Dickson '79 (Lilly), Lisa Sutton Pisenti '83, and Alvin Wong '76 (Novacea) will participate in the future with the group but were unable to attend this meeting.

We agreed to review the PharmD curriculum for key competencies needed for PharmD graduates to enter industry, and the group will suggest industry-related projects that might fit well into each of our 3 PharmD curriculum pathways. The group will also explore the possibility of clerkships within Pharma and Biotech. In turn, we will keep the group apprised of the seminars and coursework we offer to industry, our drug pipeline-related work in the lab, and our work with the United States FDA.

Thanks to Bruce for the time he invested in making the meeting happen and to Marie Parfitt Pattie, our director of development and alumni relations, for the meeting details and follow through.

Faculty Honors and Awards

Many of our faculty members received national recognition for their work since I wrote to you last. (See Ortiz de Montellano, Voigt, and Wells Recognized for Their Science.)

Paul Ortiz de Montellano, PhD, department of pharmaceutical chemistry, received the Volwiler Research Achievement Award from the American Association of Colleges of Pharmacy (AACP). The award recognizes Paul's extensive research and strong reputation in drug metabolism and his expertise in biological organic and inorganic chemistry. It is sponsored by Abbott Laboratories. (See the AACP press release.)

Christopher Voigt, PhD, department of pharmaceutical chemistry, was named one of 15 Pew Scholars for Biomedical Sciences for 2006. The honor and research support go to the most promising early-to-mid career biomedical researchers in the United States. Chris, who is a pioneer in the emerging field of synthetic biology, seeks to develop a basis by which cells can be programmed to perform complex tasks for pharmaceutical and industrial applications. His laboratory is engineering new sensors in bacteria to extend their capabilities.

James Wells, PhD, the Harry Wm. Hind and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences, department of pharmaceutical chemistry, has been named recipient of the David Perlman Award, given by the Division of Biochemical Technology of the American Chemical Society (ACS). The lecture will be presented at the national ACS meeting, to be held in San Francisco September 10 to 14, 2006.

Pamela England, PhD, department of pharmaceutical chemistry, and expert in the areas of neuroscience and memory formation, will receive one of four Technological Innovations in Neuroscience Awards for 2006-2008. The award is from The McKnight Endowment Fund for Neuroscience and supports the development of new tools and techniques in neuroscience research. Pam and her research group explore what memories are and how they are formed. Their approaches incorporate synthetic organic chemistry, biochemistry, molecular biology, and electrophysiology. The McKnight Endowment Award will fund research on the trafficking in living cells of AMPA receptors, which are thought to be important in regulating communication between neurons. (See the McKnight press release.)

C. Anthony Hunt, PhD, department of biopharmaceutical sciences, was elected as a fellow of the American Association for the Advancement of Science (AAAS).

I am also pleased to announce that Lisa Bero, PhD, department of clinical pharmacy, has been appointed to the World Heath Organization Expert Advisory Panel on Drug Policies and Management. Increasingly, the impact of our faculty members and students is international in scope.

Many of you who read this update will remember Bob Day, PharmD, as the energetic advisor to our student branch of the American Pharmacists Association (APhA). Although Bob is not retiring as our associate dean, he did surprise me and others last spring when he signaled that he would step down as student advisor after some 40 years of service—wow! It was Bob who fought for student recognition within the APhA and encouraged so many of us to speak out on professional and patient care issues that mattered to us. He gave us confidence in ourselves and validated our ideas. Bob's impact on developing future leaders at UCSF and nationally is immeasurable, but certainly significant. For these and many other contributions, Bob was given the 2006 Linwood F. Tice Friend of APhA Academy of Student Pharmacists award. Please join me in thanking him.

Global Reach

I mentioned in the February 2006 Update that student pharmacist Bryan McGee (Class of 2006) traveled to Uganda in October 2005 for 6 months as the recipient of a Fulbright Student Fellowship to study the optimum dosage and bio-equivalency of antiretroviral generics as well as optimum dosages of anti-malarial drugs in children. Troy Drysdale (Class of 2008) continued Bryan's research in Uganda this summer with support from a UCSF Pathways to Careers in Clinical and Translational Research (PACCTR) fellowship. Nguyen Nguyen (Class of 2007) spent a good part of the summer in Ho Chi Minh City where she undertook an externship in drug information and completed several special projects contrasting western and Vietnamese pharmaceutical care. At least two elective clinical rotations outside the US are in the planning stages now.

The department of clinical pharmacy welcomes two Fogarty Fellows from the University of Zimbabwe who are being mentored by Chair Joe Guglielmo, PharmD. Mr. Luther Gwaza and Ms. Tsitsi Monera are learning in vitro methods used in the evaluation of herbal-drug interactions. The 4-month training experience will be carried out in collaboration with Les Benet, PhD and Alan Wolfe, research assistant, department of biopharmaceutical sciences.

Our international focus is shared by UCSF as a whole. Interestingly, in a report released August 13, 2006 by Newsweek International, UCSF was ranked 9th among the top 100 global universities. The ranking was based on specific criteria that ranged from the number of highly cited researchers in various academic fields to the percentage of international students. Clearly the colleagues with whom we work are increasingly international and the public we now serve is increasingly a global public. Ultimately we all benefit from the exchange of different ideas, approaches, and insights. (See UCSF Ranked Ninth Among Top Global Universities.)

Li Foundation

I am very pleased to announce a new partner in our research in systems biology—the Li Foundation. The Li Foundation was established by the late Mr. K. C. Li, who was an international authority on tungsten, a successful businessman, and a philanthropist.

The Foundation, which has been supporting the science training of Chinese scholars at UCSF for more than 15 years under the able guidance of department of pharmaceutical chemistry emeritus faculty member Chin-Tzu Peng, PhD, will now provide funding for scholars from Peking University to train at UCSF in the field of systems biology. Chao Tang, PhD, department of biopharmaceutical sciences, who oversees a new systems biology partnership between Peking University and the University of California, will also oversee the Li Foundation fellowship program. Chao holds faculty positions at both Peking University and UCSF, and thus bridges our academic institutions. Chao believes that the "scientists we train in systems biology will become leaders in an era of science that flourishes without boundaries." I agree and sincerely thank the Li Foundation for its vision and for the global impact on science its support will surely make.

Medicare Part D

Before the May 15, 2006 close of the first federal Medicare Part D open enrollment period, members of the department of clinical pharmacy faculty were focused on developing and implementing new approaches to helping seniors make the best Part D choices. Much of their effort was on helping underserved seniors—those with low incomes, limited or no English language proficiency, and those who are eligible for both Medicare and Medi-Cal. (See Pharmacists Clarify the Medicare Part D Fog.)

Marilyn Stebbins, PharmD and Tim Cutler, PharmD piloted a Part D community pharmacy rotation. With a corps of trained and dedicated student pharmacists, they helped more than 2,500 seniors enroll in Part D by holding many community meetings and workshops in multiple languages. Their success strengthens our resolve to move ahead aggressively with our Part D work. We will design studies that help us make evidenced-based decisions about how to proceed most effectively for the benefit of the communities we serve.

Helene Levens Lipton, PhD added innovative sections to her required Health Policy for Pharmacists course. She used case studies to teach students the benefits, costs, and complexities of the legislation by having them present Part D from the perspectives of 6 stakeholder groups. Five of her students then went on to teach Part D to 90 graduate-level nursing students in their health policy course. The evaluations were overwhelmingly positive. One response: "It was positively inspiring to see student pharmacists serving as advocates for patients! I had never thought of pharmacists in this role before!" And another: "Please, please take your fabulous presentation on the road and help spread the word about the challenges of Part D and how pharmacists are overcoming them."

Center for Consumer Self Care (CCSC)

Under the guidance of Bill Soller, PhD, department of clinical pharmacy, our Center for Consumer Self Care is making significant contributions to the health and well-being of our neighbors across the United States. Target Stores funded the Center to study its new retail drug packaging and labeling system. The "ClearRx Study" showed overwhelming consumer preference for ClearRx compared to the conventional cylindrical bottle and label. The results have been submitted for publication and were presented at a special hearing of a subcommittee of the California State Senate dealing with medication safety.

The Oliver and Jennie Donaldson Charitable Trust renewed its support to expand last year's award-winning national awareness programs on breast and prostate cancer screening. This screening is part of the work of the California Health Communication Partnership (CHCP), which Bill was instrumental in forming.

The Center began a new residency program that cross-trains pharmacists in academia and industry. PDL BioPharma, Inc. is our industry partner for the first resident.

A telepharmacy service, which was conceived by Clifton Louie, RPh, DPA, department of clinical pharmacy, and executive director for clinical services at the UCSF Medical Center, is now up and running. The clinic connects, via live video, patients at the Saint Anthony Free Medical Clinic in downtown San Francisco with student pharmacists at the Center for Consumer Self Care's Drug Information Analysis Service on our Parnassus campus. Our students, under the guidance of faculty and resident preceptors, counsel diabetes patients one afternoon per week. My thanks to department of clinical pharmacy faculty members Bill Soller, PhD; Candy Tsourounis, PharmD; Christine Cheng, PharmD; and student researcher Amy Hawkins for getting this project up and running. We are just now looking at patient and physician satisfaction measures, and we hope to next assess clinical outcomes. If this model proves successful, we have the potential to open other telepharmacy services at Saint Anthony's, such as a cardiovascular diseases service. I thank the McKesson Foundation for its grant support of this new practice model. Not surprisingly, Clifton was awarded the Chancellor's Award for Public Service last year for his work with community clinics that provide care to the underserved. He volunteers at several health clinics in San Francisco, assisting them with licensing requirements and in providing medicines and consultation to patients who do not have health benefits.

(Read more about the Center for Consumer Self Care.)

Accreditation

It will soon be time again—in early 2008—for another accreditation review of our PharmD program by the Accreditation Council for Pharmacy Education (ACPE). We take the attitude that accreditation is a continuous process that must be addressed as accreditation standards change, as the health care marketplace changes, as science changes, and as our students change. Heading our accreditation team again is Barbara Sauer, PharmD, department of clinical pharmacy. I created a new and important post for Barbara and named her Associate Dean for Assessment and Accreditation. Joining her on a core accreditation planning committee are department of clinical pharmacy faculty members Robin Corelli, PharmD; Sharon Youmans, PharmD; Steve Kahl, PhD; and our new department chair, Joe Guglielmo, PharmD.

40th Anniversary of Clinical Pharmacy

It is hard to believe that September 7 marks the 40th anniversary of pharmacy as a clinical profession. It was on September 7, 1966 that the first satellite pharmacy on a hospital floor opened for service. The place was the 9th floor of UCSF's Moffitt Hospital, which was then dedicated to surgery patients. Now, pharmacists are integral and essential members of the health care team throughout the country and the world. I can only imagine the roles pharmacists will play on September 7, 2046 and how our School will be involved. That, my friends, is a story to be recounted by future deans.

I look forward to writing to you again this winter, when I know there again will be much to share. As always, please write or e-mail me with your thoughts, questions, and concerns.

With warm regards always,

Yours Sincerely,

signature of Mary Anne Koda-Kimble, PharmD

Mary Anne Koda-Kimble, PharmD
Professor and Dean
Thomas J. Long Chair in Community Pharmacy Practice

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Koda-Kimble

Dean Mary Anne Koda-Kimble, PharmD
School of Pharmacy
University of California, San Francisco

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Archive

  • Spring/Summer 2008
    PharmD Program reaccredited through 2014 and funding problems; Science Squad; Program for Investigation and Training for Careers in Health; Summer Science Camp; Huntington & Schweitzer Fellowship; #1 in NIH funding again; California Poison Control System at risk; tobacco ban legislation; Ambrose in Beijing; New faculty: Galonic Fujimori, Jorgenson, Ashton, Balano, Feigal, Hessol, Greenblatt; Wells succeeds James as chair, Department of Pharmaceutical Chemistry; Youmans: appointed Associate Dean of Diversity, Malawi; Dill: elected to National Academy of Sciences, The Chemistry of Life; APhA-ASP Chapter of the Year Award; 1st place in AMCP National Pharmacy and Therapeutics Competition; Bero appointed to Advisory Committee on Health Research; Retirements: Finley, Rice, Sauer, Shetlar, Weibert.
  • Fall 2007/Winter 2008
    New Strategic Plan: Pressing Ahead in New Directions: Strategic Course 2007-2012, Advancing Health Worldwide, PharmD Student Fee Increase, Honors and Awards: Day, Yokoyama, Ortiz de Montellano, Stroud, Dill, Shane, Vogt, Soller, Chan, Wang, Voigt, Wells. Papers: Sali, Sarino, Dang, Dianat, Djihanian, Natanian, Ambrose, Hudmon, Youmans, Shoichet, Feng. New faculty: Ahituv, Ikediobi, Kreager, Robinson, Shin. New Director of Pharmaceutical Services: Paulsen. In memory: Mizuno.
  • Spring/Summer 2007
    Fresno program to boost number of pharmacists. UCSF ranks 3rd in the United States in overall faculty productivity. California Poison Control System receives IN-AWE for "Don't guess. Be sure.". Preceptors survey and Advanced Pharmacy Practice Experiences (APPEs). Drug Information Analysis Service closes. New Introductory Pharmacy Practice Experience (IPPE) requirement. Articles of Interest. Tenure: Jacobson, England. Retirements: Hoener, Whitney, Winter. New Members of the Board of Advisors: Dow, Rodondi, Shane, Stalker. Honors and Awards: Wells, King, Brodsky, Szoka, Benet, Agard, Stroud, Tan. Campus Strategic Plan.
  • Fall/Winter 2007
    In Memory: Dean Jere Goyan. Student and staff honors and awards: Chinn, Farm, Almas, Beverage. Clinical scientist news and awards: Lee, Giacomini. Partners in D Outreach: Stebbins, Levens Lipton, Amgen. Chemistry and Chemical Biology Chemistry-Biology Interface grant renewal: Craik. American Course on Drug Development and Regulatory Sciences. Lee is new director of Center for Drug Development Sciences. New faculty: Ferrone. Diversity report: student URM down, faculty URM higher than United States average, staff URM up but behind UCSF overall, mission statement revised to formalize commitment. Fresno Satellite Pharmacy Education Program 5-year anniversary. American Pharmacist Association-Academy of Student Pharmacists receives Outstanding Chapter Award for the AA Division.
  • February 2006
    Guglielmo named new department of clinical pharmacy chair. New faculty members: Boyd, Burchard, Cutler, Lee, MacDougall, Nkansah, Orrico, Tang, and Wells. Parfitt Pattie now oversees alumni relations in addition to fundraising. Research highlights. Honors and awards: Langridge, Giacomini, Herfindal, Gibson, Day, Nguyen, Zlott, Drysdale, and Allday. New PhD training program in systems biology. Postgraduate education of PharmD students. Employment trends of PharmD graduates. Homecoming scheduled for November 4, 2006. School at work in China, Vietnam, Japan, Uganda, and Guatemala. Lipton finishes sabbatical at One World Health. Victoria Hale to deliver commencement address to 2006 PharmD graduates. Strategic planning delayed by multiple factors. For 25th consecutive year, School tops other pharmacy schools in research funding from the National Institutes of Health. For second consecutive year, UCSF receives more federal funding for chemical research and development than any US peer. School exceeds campaign fundraising goal by 18%.
  • March 2005
    Special Report / Fall-Winter 2005: An overview of School accomplishments based upon a written report that Dean Mary Anne Koda-Kimble, PharmD submitted to a UCSF faculty committee as part of a review of her performance as dean from 1998 to 2003. Includes updates from 2003 through March 2005. "My first 5 years as dean...and since" and more.
  • July 2004
    Bay Area Screening Center and Center for Chemical Diversity, Breathe Easy Education Program, Center for Computational Proteomics Research, AIDS epidemic in Viet Nam. New faculty members: Veenstra, Vogt, Yokoyama, Kortemme. PharmD professional fees double, governor's compact. First year using PharmCAS. Graduate program funding for international students in jeopardy. Honors, awards, standings: Giacomini, Voigt, Jacobsen, Rudd. We're #1 in NIH funding again. UCSF Medical Center is 6th with U.S. News & World Report. Lew Sheiner. Homecoming 2004. New strategic plan forthcoming.
  • February 2004
    New faculty members (Sali, Voigt, Chen, Schwarz). Systems biology and complex systems. Results of the school retreat and strategic planning. Awards and appointments (Benet, Shoichet, Winter, Ignoffo, Louie, Soller). Reactions to Governor Schwarzenegger's state budget proposals. US$6 million gift from Carl Lovotti.
  • July 2003
    Reactions to Mission Bay moves. Ideas for generating revenue to offset the California budget deficit. How we gather input and advice to shape our planning. Awards and retirements (Kuntz, McCart, Ruggiero, Sutherland). Relocation of the Office of Student & Curricular Affairs. New School of Medicine Dean David Kessler, MD. Harry W. and Diana V. Hind Distinguished Professorship in Pharmaceutical Sciences.
  • February 2003
    California budget defecit leads to UC cuts and student fee increases. Scientists move in to Mission Bay. 2003 PharmD applications up 32% over 2002. ACPE Accreditation approved. Exit survey and post-graduate survey results. Honors and awards (The Annals of Pharmacotherapy, Kuntz, Pohorille, Nguyen, Whitely).
  • July 2002
    ACPE accreditation preliminary feedback is encouraging. Governor Gray Davis calls for reductions in spending. 2002 PharmD applications up 40% over 2001.
  • January 2002
    Reactions after September 11. The State of the School Address provides a concise summary of our recent history and our future plans. Nilofar Shah completes a relief project for Afghani refugees.