My research focuses on membrane transporters, which are of great importance to drug disposition and response. I am particularly interested in genetic variants in membrane transporters that are determinants of drug response and in harnessing transporters to enhance drug targeting.
UCSF scientists are studying key drug transporters that play roles in drug absorption and elimination. Shown here:OCT2 and others in the membrane of cells in the kidney tubules (at right). The urine collecting tubules interface with capillaries (at left) to remove substances such as medications and environmental toxins from the blood.
To reduce the risk of toxic drug interactions, UCSF's Kathy Giacomini, PhD, and colleagues are screening thousands of prescription drugs, testing how much they inhibit key proteins in kidney and liver cells that help clear medications from the body.
Passengers who travel on American Airlines from September through October 2011 will learn about the surgically implantable bioartificial kidney being developed at UCSF as a permanent solution to end stage renal disease.