Tagged: Epigenetics

Update from the Dean - March 2017

Nation debates possibility of dramatically new directions for health care coverage, science funding, immigration, education; Revealing malaria/HIV drug interactions in children; Decreasing cancer drug toxicity while increasing dose; Engineering safer opioids; Evidence for comprehensive medication management; Medicare Part D as a learning model for pharmacy education—impact 10 years out; New genetic insights into diabetes drug response; Annotating the ‘dark genome’; Epigenetics of ethnicity; New endowed professorships made possible by private support; New Center for Cellular Construction; Major funding for UCSF-Stanford CERSI; 2017 Mary Anne Koda-Kimble Seed Award for Innovation; Welcoming the class of 2020; Three generations at the School of Pharmacy; Developing a curriculum for 2018 and beyond; AFPE honors Frank Szoka as Mentor of the Year; 2016 Chancellor Diversity Awards honor Marcus Ferrone and Peace Chukudi; Eddie Way celebrates 100 years; CPhA Hall of Fame honors Brian Komoto, Phillip Oppenheimer, Wilma Wong; $500M gift to campus from Helen Diller Foundation; UC statement on federal executive order restricting travel and entry.

Fragment-based discovery: using smaller molecules to solve larger challenges

To discover new drugs and chemical probes, researchers have traditionally screened small molecules—small enough by weight to pass through cell membranes. Their goal is typically to find compounds that selectively bind to a much larger protein molecule (often an enzyme) at a chemically reactive pocket known as the active site, inhibiting its activity to treat a disease or to better understand a biological process.

Danica Galonic Fujimori, PhD

Associate Professor

I am interested in the development of novel chemical tools that allow us to interrogate biological processes on a molecular level with the ultimate goal of developing novel therapeutic strategies for the treatment of cancer and infectious diseases.

Al Burlingame, PhD

Professor

My research interests focus on the development of state of the art methodologies in mass spectrometry for use in advancing our global knowledge of human biology, specifically the dynamic, epigenetic modulation and regulation of the proteome.