Kathy Giacomini, PhD, a leader in the field of pharmacogenomics, has been named the 2017 recipient of the North American Scientific Achievement Award, presented by the International Society for the Study of Xenobiotics (ISSX). ISSX is an international association of scientists that promotes the understanding of the interactions of medicines and chemicals with living systems.
UCSF scientists are studying key drug transporters that play roles in drug absorption and elimination. Shown here:OCT2 and others in the membrane of cells in the kidney tubules (at right). The urine collecting tubules interface with capillaries (at left) to remove substances such as medications and environmental toxins from the blood.
To reduce the risk of toxic drug interactions, UCSF's Kathy Giacomini, PhD, and colleagues are screening thousands of prescription drugs, testing how much they inhibit key proteins in kidney and liver cells that help clear medications from the body.