Adam Renslo, PhD

Phone: +1 415 514-9698

600 16th St, Rm N572B
UCSF Box 2280
San Francisco, CA 94158
United States

Educational programs

UCSF centers, institutes, and research programs

Associate Director, Chemistry, Small Molecule Discovery Center (SMDC)

What I do

My research group is engaged at the interface of chemistry and biology. As medicinal chemists, we design and synthesize small molecules that modulate disease pathology at the level of the enzyme, cell, and whole animal, with current projects in cancer, infectious disease, and neurodegeneration. As chemical biologists, we employ novel small molecule probes to better understand biological pathways and the mechanisms of small molecule therapeutics.

My research expertise

Targeted drug-delivery, Understanding and improving the cell permeability of peptide therapeutics, Fragment-based drug discovery, Identifying and characterizing the targets of novel small molecules

Degrees

PhD, Organic Chemistry, Massachusetts Institute of Technology (MIT), 1998
BA, Chemistry, Olaf College, 1993

Biography

My research group is engaged at the interface of chemistry and biology. As medicinal chemists, we design and synthesize small molecules that modulate disease pathology at the level of the enzyme, cell, and whole animal, with current projects in cancer, infectious disease, and neurodegeneration. As chemical biologists, we employ novel small molecule probes to better understand biological pathways and the mechanisms of small molecule therapeutics. Using such small molecule probes, we are exploring the mechanisms underlying the action of artemisinin and related antimalarial drugs. Finally, we are inventing and employing new platform technologies in an effort to expand the realm of druggable target space and drug-like chemical space. These technologies include fragment-based approaches to target protein-protein interfaces and allosteric modulation of enzymes, the use of novel unnatural amino acids to discover cell-permeable peptides, and new targeted prodrug approaches in cancer and infectious disease.